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Article: Proliferative activity as detected by immunostaining with Ki-67 and proliferating cell nuclear antigen in benign and malignant epithelial lesions of the human parotid gland

TitleProliferative activity as detected by immunostaining with Ki-67 and proliferating cell nuclear antigen in benign and malignant epithelial lesions of the human parotid gland
Authors
Issue Date1999
PublisherScience Printers and Publishers, Inc. The Journal's web site is located at http://www.aqch.com
Citation
Analytical And Quantitative Cytology And Histology, 1999, v. 21 n. 4, p. 336-342 How to Cite?
AbstractOBJECTIVE: A retrospective immunohistochemical study of parotid gland lesions was designed to evaluate the diagnostic and prognostic value of the proliferating cell nuclear antigen (PCNA) and Ki-67 with monoclonal antibodies PC 10 and MIB-1, respectively. STUDY DESIGN: Tissue samples comprised normal parotid gland (N, n=10), chronic sialadenitis (CS, n = 8), Warthin's tumor (W, n = 10), benign pleomorphic adenoma (BPA, n=8), mucoepidermoid carcinoma (MEC, n= 13), carcinoma in pleomorphic adenoma (CPA, n=8) and adenoid cystic carcinoma (ACC, n = 12). The morphometric parameters for PCNA and MIB-1 comprised the PI and MI labelling indices (the numerical percentage of positive nuclei), N(AP) and N(AM) (the numerical density of positive nuclei), and NPI and NMI (volume corrected index). RESULTS: The values of MIB-1 parameters increased progressively in benign lesions in comparison with the N group and in malignant neoplasms in comparison with nonneoplastic groups and benign lesions. Values for all parameters in BPA were significantly lower than those in malignant groups. Spearman rank correlation analysis showed a highly positive correlation between the morphometric parameters and severity of the lesions. The mean values of MI and NMI were significantly higher in patients who died of the malignant tumors than in those who survived. The same quantitative parameters for PCNA did not differ significantly from those obtained for MIB-1 and showed similar trends. CONCLUSION: PCNA and MIB-1 indices are reliable markers for discriminating between benign and malignant tumors of the parotid gland, and the parameters PL, MI, NPI and NMI may have prognostic applications.
Persistent Identifierhttp://hdl.handle.net/10722/67725
ISSN
2015 Impact Factor: 0.918
2015 SCImago Journal Rankings: 0.291
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, Qen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorWhite, FHen_HK
dc.date.accessioned2010-09-06T05:57:41Z-
dc.date.available2010-09-06T05:57:41Z-
dc.date.issued1999en_HK
dc.identifier.citationAnalytical And Quantitative Cytology And Histology, 1999, v. 21 n. 4, p. 336-342en_HK
dc.identifier.issn0884-6812en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67725-
dc.description.abstractOBJECTIVE: A retrospective immunohistochemical study of parotid gland lesions was designed to evaluate the diagnostic and prognostic value of the proliferating cell nuclear antigen (PCNA) and Ki-67 with monoclonal antibodies PC 10 and MIB-1, respectively. STUDY DESIGN: Tissue samples comprised normal parotid gland (N, n=10), chronic sialadenitis (CS, n = 8), Warthin's tumor (W, n = 10), benign pleomorphic adenoma (BPA, n=8), mucoepidermoid carcinoma (MEC, n= 13), carcinoma in pleomorphic adenoma (CPA, n=8) and adenoid cystic carcinoma (ACC, n = 12). The morphometric parameters for PCNA and MIB-1 comprised the PI and MI labelling indices (the numerical percentage of positive nuclei), N(AP) and N(AM) (the numerical density of positive nuclei), and NPI and NMI (volume corrected index). RESULTS: The values of MIB-1 parameters increased progressively in benign lesions in comparison with the N group and in malignant neoplasms in comparison with nonneoplastic groups and benign lesions. Values for all parameters in BPA were significantly lower than those in malignant groups. Spearman rank correlation analysis showed a highly positive correlation between the morphometric parameters and severity of the lesions. The mean values of MI and NMI were significantly higher in patients who died of the malignant tumors than in those who survived. The same quantitative parameters for PCNA did not differ significantly from those obtained for MIB-1 and showed similar trends. CONCLUSION: PCNA and MIB-1 indices are reliable markers for discriminating between benign and malignant tumors of the parotid gland, and the parameters PL, MI, NPI and NMI may have prognostic applications.en_HK
dc.languageengen_HK
dc.publisherScience Printers and Publishers, Inc. The Journal's web site is located at http://www.aqch.comen_HK
dc.relation.ispartofAnalytical and Quantitative Cytology and Histologyen_HK
dc.subject.meshAdenocarcinoma - chemistry - diagnosisen_HK
dc.subject.meshAdenolymphoma - chemistry - diagnosisen_HK
dc.subject.meshAdenoma, Pleomorphic - chemistry - diagnosisen_HK
dc.subject.meshCarcinoma, Adenoid Cystic - chemistry - diagnosisen_HK
dc.subject.meshCarcinoma, Mucoepidermoid - chemistry - diagnosisen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshDiagnosis, Differentialen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Cytometry - methodsen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshKi-67 Antigen - analysisen_HK
dc.subject.meshNeoplasms, Multiple Primary - chemistry - diagnosisen_HK
dc.subject.meshParotid Gland - chemistry - pathologyen_HK
dc.subject.meshParotid Neoplasms - chemistry - diagnosisen_HK
dc.subject.meshProliferating Cell Nuclear Antigen - analysisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSialadenitis - diagnosis - metabolismen_HK
dc.titleProliferative activity as detected by immunostaining with Ki-67 and proliferating cell nuclear antigen in benign and malignant epithelial lesions of the human parotid glanden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0884-6812&volume=21 No4&spage=336&epage=342&date=1999&atitle=Proliferative+activity+as+detected+by+immunostaining+with+Ki-67+and+proliferating+cell+nuclear+antigen+in+benign+and+malignant+epithelial+lesions+of+the+human+parotid+glanden_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10560511-
dc.identifier.scopuseid_2-s2.0-0032855672en_HK
dc.identifier.hkuros47658en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032855672&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage336en_HK
dc.identifier.epage342en_HK
dc.identifier.isiWOS:000082008300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhu, Q=16026167700en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridWhite, FH=7202578907en_HK

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