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Article: Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons

TitleIntraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons
Authors
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcne
Citation
Molecular And Cellular Neuroscience, 2003, v. 22 n. 1, p. 49-61 How to Cite?
AbstractIn vitro, cyclic AMP (cAMP) elevation alters neuronal responsiveness to diffusible growth factors and myelin-associated inhibitory molecules. Here we used an established in vivo model of adult central nervous system injury to investigate the effects of elevated cAMP on neuronal survival and axonal regeneration. We studied the effects of intraocular injections of neurotrophic factors and/or a cAMP analogue (CPT-cAMP) on the regeneration of axotomized rat retinal ganglion cell (RGC) axons into peripheral nerve autografts. Elevation of cAMP alone did not significantly increase RGC survival or the number of regenerating RGCs. Ciliary neurotrophic factor increased RGC viability and axonal regrowth, the latter effect substantially enhanced by coapplication with CPT-cAMP. Under these conditions over 60% of surviving RGCs regenerated their axons. Neurotrophin-4/5 injections also increased RGC viability, but there was reduced long-distance axonal regrowth into grafts, an effect partially ameliorated by cAMP elevation. Thus, cAMP can act cooperatively with appropriate neurotrophic factors to promote axonal regeneration in the injured adult mammalian central nervous system. © 2003 Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67710
ISSN
2015 Impact Factor: 3.597
2015 SCImago Journal Rankings: 2.342
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCui, Qen_HK
dc.contributor.authorYip, HKen_HK
dc.contributor.authorZhao, RCHen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorHarvey, ARen_HK
dc.date.accessioned2010-09-06T05:57:34Z-
dc.date.available2010-09-06T05:57:34Z-
dc.date.issued2003en_HK
dc.identifier.citationMolecular And Cellular Neuroscience, 2003, v. 22 n. 1, p. 49-61en_HK
dc.identifier.issn1044-7431en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67710-
dc.description.abstractIn vitro, cyclic AMP (cAMP) elevation alters neuronal responsiveness to diffusible growth factors and myelin-associated inhibitory molecules. Here we used an established in vivo model of adult central nervous system injury to investigate the effects of elevated cAMP on neuronal survival and axonal regeneration. We studied the effects of intraocular injections of neurotrophic factors and/or a cAMP analogue (CPT-cAMP) on the regeneration of axotomized rat retinal ganglion cell (RGC) axons into peripheral nerve autografts. Elevation of cAMP alone did not significantly increase RGC survival or the number of regenerating RGCs. Ciliary neurotrophic factor increased RGC viability and axonal regrowth, the latter effect substantially enhanced by coapplication with CPT-cAMP. Under these conditions over 60% of surviving RGCs regenerated their axons. Neurotrophin-4/5 injections also increased RGC viability, but there was reduced long-distance axonal regrowth into grafts, an effect partially ameliorated by cAMP elevation. Thus, cAMP can act cooperatively with appropriate neurotrophic factors to promote axonal regeneration in the injured adult mammalian central nervous system. © 2003 Elsevier Science (USA). All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcneen_HK
dc.relation.ispartofMolecular and Cellular Neuroscienceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshBrain Tissue Transplantationen_HK
dc.subject.meshCarbocyanines - diagnostic useen_HK
dc.subject.meshCell Survival - drug effects - physiologyen_HK
dc.subject.meshCiliary Neurotrophic Factor - metabolism - pharmacologyen_HK
dc.subject.meshCyclic AMP - analogs & derivatives - metabolism - pharmacologyen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFluorescein-5-isothiocyanate - diagnostic useen_HK
dc.subject.meshFluorescent Dyes - diagnostic useen_HK
dc.subject.meshGrowth Cones - drug effects - metabolism - ultrastructureen_HK
dc.subject.meshNerve Growth Factors - metabolism - pharmacologyen_HK
dc.subject.meshNerve Regeneration - drug effects - physiologyen_HK
dc.subject.meshPeripheral Nerves - transplantationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRetina - drug effects - growth & development - injuriesen_HK
dc.subject.meshRetinal Ganglion Cells - cytology - drug effects - metabolismen_HK
dc.subject.meshStilbamidinesen_HK
dc.subject.meshThionucleotides - pharmacologyen_HK
dc.subject.meshTubulin - metabolismen_HK
dc.subject.meshUp-Regulation - drug effects - physiologyen_HK
dc.titleIntraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axonsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1044-7431&volume=22&spage=49&epage=61&date=2003&atitle=Intraocular+elevation+of+cyclic+AMP+potentiates+ciliary+neurotrophic+factor-induced+regeneration+of+adult+rat+retinal+ganglion+cell+axonsen_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1044-7431(02)00037-4en_HK
dc.identifier.pmid12595238-
dc.identifier.scopuseid_2-s2.0-0037285301en_HK
dc.identifier.hkuros75815en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037285301&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue1en_HK
dc.identifier.spage49en_HK
dc.identifier.epage61en_HK
dc.identifier.isiWOS:000181353400005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCui, Q=7103080164en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK
dc.identifier.scopusauthoridZhao, RCH=25957811400en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridHarvey, AR=7402410218en_HK

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