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Article: Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

TitleNano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision
Authors
KeywordsCNS regeneration
Nanomedicine
Tissue repair
Issue Date2006
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 13, p. 5054-5059 How to Cite?
AbstractNanotechnology is often associated with materials fabrication, microelectronics, and microfluidics. Until now, the use of nanotechnology and molecular self assembly in biomedicine to repair injured brain structures has not been explored. To achieve axonal regeneration after injury in the CNS, several formidable barriers must be overcome, such as scar tissue formation after tissue injury, gaps in nervous tissue formed during phagocytosis of dying cells after injury, and the failure of many adult neurons to initiate axonal extension. Using the mammalian visual system as a model, we report that a designed self-assembling peptide nanofiber scaffold creates a permissive environment for axons not only to regenerate through the site of an acute injury but also to knit the brain tissue together. In experiments using a severed optic tract in the hamster, we show that regenerated axons reconnect to target tissues with sufficient density to promote functional return of vision, as evidenced by visually elicited orienting behavior. The peptide nanofiber scaffold not only represents a previously undiscovered nanobiomedical technology for tissue repair and restoration but also raises the possibility of effective treatment of CNS and other tissue or organ trauma. © 2006 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/67706
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorYou, SWen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorZhang, Sen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorSchneider, GEen_HK
dc.date.accessioned2010-09-06T05:57:31Z-
dc.date.available2010-09-06T05:57:31Z-
dc.date.issued2006en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 13, p. 5054-5059en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67706-
dc.description.abstractNanotechnology is often associated with materials fabrication, microelectronics, and microfluidics. Until now, the use of nanotechnology and molecular self assembly in biomedicine to repair injured brain structures has not been explored. To achieve axonal regeneration after injury in the CNS, several formidable barriers must be overcome, such as scar tissue formation after tissue injury, gaps in nervous tissue formed during phagocytosis of dying cells after injury, and the failure of many adult neurons to initiate axonal extension. Using the mammalian visual system as a model, we report that a designed self-assembling peptide nanofiber scaffold creates a permissive environment for axons not only to regenerate through the site of an acute injury but also to knit the brain tissue together. In experiments using a severed optic tract in the hamster, we show that regenerated axons reconnect to target tissues with sufficient density to promote functional return of vision, as evidenced by visually elicited orienting behavior. The peptide nanofiber scaffold not only represents a previously undiscovered nanobiomedical technology for tissue repair and restoration but also raises the possibility of effective treatment of CNS and other tissue or organ trauma. © 2006 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.rightsProceedings of the National Academy of Sciences. Copyright © National Academy of Sciences.en_HK
dc.subjectCNS regenerationen_HK
dc.subjectNanomedicineen_HK
dc.subjectTissue repairen_HK
dc.subject.meshAging - physiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - pathology - physiologyen_HK
dc.subject.meshBrain - pathology - physiologyen_HK
dc.subject.meshBrain Injuries - pathology - therapyen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNanomedicineen_HK
dc.subject.meshNanostructures - chemistryen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshPeptides - chemistry - metabolismen_HK
dc.subject.meshVision, Ocular - physiologyen_HK
dc.subject.meshWound Healingen_HK
dc.titleNano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of visionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=103&issue=13&spage=5054&epage=5059&date=2006&atitle=Nano+neuro+knitting:+peptide+nanofiber+scaffold+for+brain+repair+and+axon+regeneration+with+functional+return+of+visionen_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.0600559103en_HK
dc.identifier.pmid16549776-
dc.identifier.scopuseid_2-s2.0-33645504776en_HK
dc.identifier.hkuros115435en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645504776&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue13en_HK
dc.identifier.spage5054en_HK
dc.identifier.epage5059en_HK
dc.identifier.isiWOS:000236472500048-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridYou, SW=8226423300en_HK
dc.identifier.scopusauthoridTay, DKC=55392935900en_HK
dc.identifier.scopusauthoridZhang, S=7409370463en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridSchneider, GE=55057824300en_HK
dc.identifier.citeulike5451415-

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