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Article: Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord

TitleLithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord
Authors
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 2007, v. 206 n. 2, p. 296-307 How to Cite?
AbstractTransplantation of neural progenitor cells (NPCs) holds great potential for the treatment of spinal cord injuries. The survival and differential fates of transplanted NPCs in the cord are key factors contributing to the success of the therapy. In this study, we investigate the effects of lithium, a widely used antidepressant drug, on the survival, proliferation and differentiation of spinal cord-derived NPCs in cultures and after transplantation into the spinal cord. Our results show that clinically relevant doses of lithium increase the proliferation of grafted NPCs at 2 weeks post-grafting and neuronal generation by grafted NPCs at 2 weeks and 4 weeks post-grafting. However, lithium does not cause preferential differentiation of NPCs into astrocytes or oligodendrocytes both in vitro and after transplantation. Our results also show that chronic treatment with lithium (up to 4 weeks) reduces microglia and macrophage activation, indicating that lithium treatment can affect the host immune response. The results of the present study provide evidence that lithium may have therapeutic potential in cell replacement strategies for CNS injury due to its ability to promote proliferation and neuronal generation of grafted NPCs and reduce the host immune reaction. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67705
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSu, Hen_HK
dc.contributor.authorChu, THen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:57:31Z-
dc.date.available2010-09-06T05:57:31Z-
dc.date.issued2007en_HK
dc.identifier.citationExperimental Neurology, 2007, v. 206 n. 2, p. 296-307en_HK
dc.identifier.issn0014-4886en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67705-
dc.description.abstractTransplantation of neural progenitor cells (NPCs) holds great potential for the treatment of spinal cord injuries. The survival and differential fates of transplanted NPCs in the cord are key factors contributing to the success of the therapy. In this study, we investigate the effects of lithium, a widely used antidepressant drug, on the survival, proliferation and differentiation of spinal cord-derived NPCs in cultures and after transplantation into the spinal cord. Our results show that clinically relevant doses of lithium increase the proliferation of grafted NPCs at 2 weeks post-grafting and neuronal generation by grafted NPCs at 2 weeks and 4 weeks post-grafting. However, lithium does not cause preferential differentiation of NPCs into astrocytes or oligodendrocytes both in vitro and after transplantation. Our results also show that chronic treatment with lithium (up to 4 weeks) reduces microglia and macrophage activation, indicating that lithium treatment can affect the host immune response. The results of the present study provide evidence that lithium may have therapeutic potential in cell replacement strategies for CNS injury due to its ability to promote proliferation and neuronal generation of grafted NPCs and reduce the host immune reaction. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_HK
dc.relation.ispartofExperimental Neurologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Genetically Modifieden_HK
dc.subject.meshCell Differentiation - drug effectsen_HK
dc.subject.meshCell Proliferation - drug effectsen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGliosis - drug therapy - prevention & controlen_HK
dc.subject.meshGraft Rejection - drug therapy - prevention & controlen_HK
dc.subject.meshGraft Survival - drug effects - physiologyen_HK
dc.subject.meshLithium Compounds - pharmacology - therapeutic useen_HK
dc.subject.meshNeurons - drug effects - physiologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSpinal Cord - drug effects - physiology - surgeryen_HK
dc.subject.meshSpinal Cord Injuries - drug therapy - physiopathologyen_HK
dc.subject.meshStem Cell Transplantation - methodsen_HK
dc.subject.meshStem Cells - drug effects - physiologyen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleLithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal corden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-4886&volume=206&spage=296&epage=307&date=2007&atitle=Lithium+enhances+proliferation+and+neuronal+differentiation+of+neural+progenitor+cells+in+vitro+and+after+transplantation+into+the+adult+rat+spinal+corden_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.expneurol.2007.05.018en_HK
dc.identifier.pmid17599835-
dc.identifier.scopuseid_2-s2.0-34447649395en_HK
dc.identifier.hkuros137871en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447649395&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume206en_HK
dc.identifier.issue2en_HK
dc.identifier.spage296en_HK
dc.identifier.epage307en_HK
dc.identifier.eissn1090-2430-
dc.identifier.isiWOS:000248677200016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSu, H=16317750200en_HK
dc.identifier.scopusauthoridChu, TH=14023966500en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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