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Article: Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas

TitleKaryotypic evolution and tumor progression in head and neck squamous cell carcinomas
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2005, v. 156 n. 1, p. 1-7 How to Cite?
AbstractCytogenetic analysis was performed on primary tumors, and paired recurrent or metastatic lesions, in 14 patients with head and neck squamous cell carcinomas (HNSCC), in order to identify chromosomal aberrations associated with tumor initiation and progression. Abnormal karyotypes were found in 12 of the 14 patients, with distinctive karyotypic similarities shown in all informative pairs. For individual patients, the degree of karyotypic complexity was similar for the primaries and paired recurrent or metastatic lesions. All 22 samples with clonal chromosomal aberrations displayed complex karyotypes with multiple numerical and unbalanced structural rearrangements, resulting in extensive genomic imbalances. The pathway of clonal evolution could be traced in a few patients, supporting the notion that some aberrations or imbalances, particularly partial or entire loss of 3p, i(8q), and homogeneously staining regions commonly mapping to 11q13, were early genetic events in the initiation of HNSCC. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67702
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_HK
dc.contributor.authorJin, Cen_HK
dc.contributor.authorLv, Men_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorZhu, Jen_HK
dc.contributor.authorWennerberg, Jen_HK
dc.contributor.authorMertens, Fen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T05:57:29Z-
dc.date.available2010-09-06T05:57:29Z-
dc.date.issued2005en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2005, v. 156 n. 1, p. 1-7en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67702-
dc.description.abstractCytogenetic analysis was performed on primary tumors, and paired recurrent or metastatic lesions, in 14 patients with head and neck squamous cell carcinomas (HNSCC), in order to identify chromosomal aberrations associated with tumor initiation and progression. Abnormal karyotypes were found in 12 of the 14 patients, with distinctive karyotypic similarities shown in all informative pairs. For individual patients, the degree of karyotypic complexity was similar for the primaries and paired recurrent or metastatic lesions. All 22 samples with clonal chromosomal aberrations displayed complex karyotypes with multiple numerical and unbalanced structural rearrangements, resulting in extensive genomic imbalances. The pathway of clonal evolution could be traced in a few patients, supporting the notion that some aberrations or imbalances, particularly partial or entire loss of 3p, i(8q), and homogeneously staining regions commonly mapping to 11q13, were early genetic events in the initiation of HNSCC. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics . Copyright © Elsevier Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathologyen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHead and Neck Neoplasms - genetics - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNeoplasm Recurrence, Local - geneticsen_HK
dc.titleKaryotypic evolution and tumor progression in head and neck squamous cell carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=156&issue=1&spage=1&epage=7&date=2005&atitle=Karyotypic+evolution+and+tumor+progression+in+head+and+neck+squamous+cell+carcinomas+en_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cancergencyto.2004.04.023en_HK
dc.identifier.pmid15588849-
dc.identifier.scopuseid_2-s2.0-10044280589en_HK
dc.identifier.hkuros99336en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10044280589&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume156en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage7en_HK
dc.identifier.isiWOS:000226016900001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJin, Y=7404457413en_HK
dc.identifier.scopusauthoridJin, C=7401659093en_HK
dc.identifier.scopusauthoridLv, M=55222421600en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridZhu, J=16481559400en_HK
dc.identifier.scopusauthoridWennerberg, J=7007085924en_HK
dc.identifier.scopusauthoridMertens, F=7101611996en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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