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Article: Telomerase activation in nasopharyngeal carcinomas

TitleTelomerase activation in nasopharyngeal carcinomas
Authors
KeywordsNasopharyngeal carcinoma
Telomerase activation
Xenograft
Issue Date1998
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 1998, v. 77 n. 3, p. 456-460 How to Cite?
AbstractNasopharyngeal carcinomas (NPC) are common in Hong Kong and southern China but rare in Western countries. Telomerase activation is common in human cancers but has not been reported previously in NPC. Telomerase activation in NPC was determined using the sensitive TRAP (telomerase rapid amplification protocol) assay in 45 nasopharyngeal biopsies (36 NPC, nine normal nasopharyngeal mucosae) in four xenografted NPC tumours established in nude mice and in five in vitro NPC cell lines. Telomerase activation is common in NPC and can be detected at high frequencies (85% in primary tumours and 100% in recurrent tumours). The frequency of telomerase activation was lowest in NPC biopsies without lymph node involvement (60%) compared with those with positive lymph node involvement (100%), and the difference is statistically significant (P < 0.05; Fisher exact test). All the xenografted NPC tumours and in vitro NPC cell lines were strongly positive for telomerase activity. Our results suggest that telomerase activation is common in NPC and it may be useful as a diagnostic marker in the detection of tumour cells in nasopharyngeal biopsies. The high frequency of telomerase activation in stage I NPC (80% positive) suggests that it is an early event in tumour progression.
Persistent Identifierhttp://hdl.handle.net/10722/67693
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, RYSen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorZheng, Zen_HK
dc.contributor.authorWei, Wen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorYang, XHen_HK
dc.contributor.authorCao, Len_HK
dc.contributor.authorHuang, DPen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2010-09-06T05:57:24Z-
dc.date.available2010-09-06T05:57:24Z-
dc.date.issued1998en_HK
dc.identifier.citationBritish Journal Of Cancer, 1998, v. 77 n. 3, p. 456-460en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67693-
dc.description.abstractNasopharyngeal carcinomas (NPC) are common in Hong Kong and southern China but rare in Western countries. Telomerase activation is common in human cancers but has not been reported previously in NPC. Telomerase activation in NPC was determined using the sensitive TRAP (telomerase rapid amplification protocol) assay in 45 nasopharyngeal biopsies (36 NPC, nine normal nasopharyngeal mucosae) in four xenografted NPC tumours established in nude mice and in five in vitro NPC cell lines. Telomerase activation is common in NPC and can be detected at high frequencies (85% in primary tumours and 100% in recurrent tumours). The frequency of telomerase activation was lowest in NPC biopsies without lymph node involvement (60%) compared with those with positive lymph node involvement (100%), and the difference is statistically significant (P < 0.05; Fisher exact test). All the xenografted NPC tumours and in vitro NPC cell lines were strongly positive for telomerase activity. Our results suggest that telomerase activation is common in NPC and it may be useful as a diagnostic marker in the detection of tumour cells in nasopharyngeal biopsies. The high frequency of telomerase activation in stage I NPC (80% positive) suggests that it is an early event in tumour progression.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectTelomerase activationen_HK
dc.subjectXenograften_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshEnzyme Activationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - enzymologyen_HK
dc.subject.meshNeoplasm Transplantationen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshTelomerase - metabolismen_HK
dc.subject.meshTransplantation, Heterologousen_HK
dc.titleTelomerase activation in nasopharyngeal carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=77&issue=3&spage=456&epage=460&date=1998&atitle=Telomerase+activation+in+nasopharyngeal+carcinomasen_HK
dc.identifier.emailNicholls, JM: nicholls@pathology.hku.hken_HK
dc.identifier.emailWei, W: hrmswwi@hku.hken_HK
dc.identifier.emailTsao, SW: gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityWei, W=rp00323en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid9472643en_HK
dc.identifier.scopuseid_2-s2.0-14444288069en_HK
dc.identifier.hkuros29783en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14444288069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue3en_HK
dc.identifier.spage456en_HK
dc.identifier.epage460en_HK
dc.identifier.isiWOS:000071799300016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheng, RYS=7201955319en_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridZheng, Z=36792437600en_HK
dc.identifier.scopusauthoridWei, W=7403321552en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridYang, XH=18839356200en_HK
dc.identifier.scopusauthoridCao, L=7401637818en_HK
dc.identifier.scopusauthoridHuang, DP=7403891486en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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