Article: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract

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TitleTropism of avian influenza A (H5N1) in the upper and lower respiratory tract
AuthorsNicholls, JM1
Chan, MCW1
Chan, WY1
Wong, HK1
Cheung, CY1
Kwong, DLW1
Wong, MP1
Chui, WH2
Poon, LLM1
Tsao, SW1
Guan, Y1
Peiris, JSM1
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm
CitationNature Medicine, 2007, v. 13 n. 2, p. 147-149 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nm1529
AbstractPoor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. © 2007 Nature Publishing Group.
ISSN1078-8956
2011 Impact Factor: 22.462
2011 SCImago Journal Rankings: 4.452
DOIhttp://dx.doi.org/10.1038/nm1529
ISI Accession Number IDWOS:000244031700022
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNicholls, JM
dc.contributor.authorChan, MCW
dc.contributor.authorChan, WY
dc.contributor.authorWong, HK
dc.contributor.authorCheung, CY
dc.contributor.authorKwong, DLW
dc.contributor.authorWong, MP
dc.contributor.authorChui, WH
dc.contributor.authorPoon, LLM
dc.contributor.authorTsao, SW
dc.contributor.authorGuan, Y
dc.contributor.authorPeiris, JSM
dc.date.accessioned2010-09-06T05:57:22Z
dc.date.available2010-09-06T05:57:22Z
dc.date.issued2007
dc.description.abstractPoor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. © 2007 Nature Publishing Group.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNature Medicine, 2007, v. 13 n. 2, p. 147-149 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nm1529
dc.identifier.citeulike1091781
dc.identifier.doihttp://dx.doi.org/10.1038/nm1529
dc.identifier.epage149
dc.identifier.hkuros151573
dc.identifier.isiWOS:000244031700022
dc.identifier.issn1078-8956
2011 Impact Factor: 22.462
2011 SCImago Journal Rankings: 4.452
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid17206149
dc.identifier.scopuseid_2-s2.0-33846995616
dc.identifier.spage147
dc.identifier.urihttp://hdl.handle.net/10722/67689
dc.identifier.volume13
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm
dc.publisher.placeUnited States
dc.relation.ispartofNature Medicine
dc.relation.referencesReferences in Scopus
dc.subject.meshInfluenza A Virus, H5N1 Subtype - metabolism
dc.subject.meshInfluenza, Human - metabolism - transmission
dc.subject.meshReceptors, Cell Surface - metabolism
dc.subject.meshRespiratory System - virology
dc.subject.meshVirus Attachment
dc.titleTropism of avian influenza A (H5N1) in the upper and lower respiratory tract
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Grantham Hospital Hong Kong