Supplementary

Article: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
  • Basic View
  • Metadata View
  • XML View
TitleTropism of avian influenza A (H5N1) in the upper and lower respiratory tract
 
AuthorsNicholls, JM1
Chan, MCW1
Chan, WY1
Wong, HK1
Cheung, CY1
Kwong, DLW1
Wong, MP1
Chui, WH2
Poon, LLM1
Tsao, SW1
Guan, Y1
Peiris, JSM1
 
Issue Date2007
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm
 
CitationNature Medicine, 2007, v. 13 n. 2, p. 147-149 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nm1529
 
AbstractPoor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. © 2007 Nature Publishing Group.
 
ISSN1078-8956
2012 Impact Factor: 22.864
2012 SCImago Journal Rankings: 8.315
 
DOIhttp://dx.doi.org/10.1038/nm1529
 
ISI Accession Number IDWOS:000244031700022
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNicholls, JM
 
dc.contributor.authorChan, MCW
 
dc.contributor.authorChan, WY
 
dc.contributor.authorWong, HK
 
dc.contributor.authorCheung, CY
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorWong, MP
 
dc.contributor.authorChui, WH
 
dc.contributor.authorPoon, LLM
 
dc.contributor.authorTsao, SW
 
dc.contributor.authorGuan, Y
 
dc.contributor.authorPeiris, JSM
 
dc.date.accessioned2010-09-06T05:57:22Z
 
dc.date.available2010-09-06T05:57:22Z
 
dc.date.issued2007
 
dc.description.abstractPoor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. © 2007 Nature Publishing Group.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNature Medicine, 2007, v. 13 n. 2, p. 147-149 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nm1529
 
dc.identifier.citeulike1091781
 
dc.identifier.doihttp://dx.doi.org/10.1038/nm1529
 
dc.identifier.eissn1546-170X
 
dc.identifier.epage149
 
dc.identifier.hkuros151573
 
dc.identifier.isiWOS:000244031700022
 
dc.identifier.issn1078-8956
2012 Impact Factor: 22.864
2012 SCImago Journal Rankings: 8.315
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid17206149
 
dc.identifier.scopuseid_2-s2.0-33846995616
 
dc.identifier.spage147
 
dc.identifier.urihttp://hdl.handle.net/10722/67689
 
dc.identifier.volume13
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNature Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshInfluenza A Virus, H5N1 Subtype - metabolism
 
dc.subject.meshInfluenza, Human - metabolism - transmission
 
dc.subject.meshReceptors, Cell Surface - metabolism
 
dc.subject.meshRespiratory System - virology
 
dc.subject.meshVirus Attachment
 
dc.titleTropism of avian influenza A (H5N1) in the upper and lower respiratory tract
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Nicholls, JM</contributor.author>
<contributor.author>Chan, MCW</contributor.author>
<contributor.author>Chan, WY</contributor.author>
<contributor.author>Wong, HK</contributor.author>
<contributor.author>Cheung, CY</contributor.author>
<contributor.author>Kwong, DLW</contributor.author>
<contributor.author>Wong, MP</contributor.author>
<contributor.author>Chui, WH</contributor.author>
<contributor.author>Poon, LLM</contributor.author>
<contributor.author>Tsao, SW</contributor.author>
<contributor.author>Guan, Y</contributor.author>
<contributor.author>Peiris, JSM</contributor.author>
<date.accessioned>2010-09-06T05:57:22Z</date.accessioned>
<date.available>2010-09-06T05:57:22Z</date.available>
<date.issued>2007</date.issued>
<identifier.citation>Nature Medicine, 2007, v. 13 n. 2, p. 147-149</identifier.citation>
<identifier.issn>1078-8956</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/67689</identifier.uri>
<description.abstract>Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid &#945;2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. &#169; 2007 Nature Publishing Group.</description.abstract>
<language>eng</language>
<publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/nm</publisher>
<relation.ispartof>Nature Medicine</relation.ispartof>
<subject.mesh>Influenza A Virus, H5N1 Subtype - metabolism</subject.mesh>
<subject.mesh>Influenza, Human - metabolism - transmission</subject.mesh>
<subject.mesh>Receptors, Cell Surface - metabolism</subject.mesh>
<subject.mesh>Respiratory System - virology</subject.mesh>
<subject.mesh>Virus Attachment</subject.mesh>
<title>Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=1078-8956&amp;volume=13&amp;issue=2&amp;spage=147&amp;epage=149&amp;date=2007&amp;atitle=Tropism+of+avian+influenza+A+(H5N1)+in+the+upper+and+lower+respiratory+tract</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1038/nm1529</identifier.doi>
<identifier.pmid>17206149</identifier.pmid>
<identifier.scopus>eid_2-s2.0-33846995616</identifier.scopus>
<identifier.hkuros>151573</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846995616&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>13</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>147</identifier.spage>
<identifier.epage>149</identifier.epage>
<identifier.eissn>1546-170X</identifier.eissn>
<identifier.isi>WOS:000244031700022</identifier.isi>
<publisher.place>United States</publisher.place>
<identifier.citeulike>1091781</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Grantham Hospital Hong Kong