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Article: Expression of telomerase reverse transcriptase in adult goldfish retina

TitleExpression of telomerase reverse transcriptase in adult goldfish retina
Authors
Issue Date2007
PublisherHumana Press, Inc.
Citation
Journal Of Molecular Neuroscience, 2007, v. 32 n. 2, p. 160-167 How to Cite?
AbstractTelomerase, a specialized reverse transcriptase that maintains telomere during cell division, is commonly associated with cell proliferation. Increasing evidence suggests that telomerase may bear functions other than telomere elongation. We investigated whether telomerase is expressed in the continuously growing goldfish retina. Telomeric repeat amplification protocol (TRAP) assay reveals telomerase activity in goldfish retina. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot show that telomerase catalytic subunit (TERT) is expressed at both mRNA and protein levels. Localization of TERT by immunohistochemistry indicates prominent expression of TERT in the outer nuclear layer, the inner nuclear layer, and, in a small population of cells, in the ganglion cell layer. Coexpression of TERT with proliferative cell nuclear antigen (PCNA) immunoreactivity is found in rod progenitor cells. These results suggest the role of telomerase in vertebrate central nervous system (CNS) other than telomere maintenance, such as regulation of cell cycle progression and maintenance of retinal cell phenotypes. © Humana Press Inc. 2007.
Persistent Identifierhttp://hdl.handle.net/10722/67688
ISSN
2015 Impact Factor: 2.352
2015 SCImago Journal Rankings: 0.988
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorTsao, GSWen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKen_HK
dc.date.accessioned2010-09-06T05:57:21Z-
dc.date.available2010-09-06T05:57:21Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Molecular Neuroscience, 2007, v. 32 n. 2, p. 160-167en_HK
dc.identifier.issn0895-8696en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67688-
dc.description.abstractTelomerase, a specialized reverse transcriptase that maintains telomere during cell division, is commonly associated with cell proliferation. Increasing evidence suggests that telomerase may bear functions other than telomere elongation. We investigated whether telomerase is expressed in the continuously growing goldfish retina. Telomeric repeat amplification protocol (TRAP) assay reveals telomerase activity in goldfish retina. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot show that telomerase catalytic subunit (TERT) is expressed at both mRNA and protein levels. Localization of TERT by immunohistochemistry indicates prominent expression of TERT in the outer nuclear layer, the inner nuclear layer, and, in a small population of cells, in the ganglion cell layer. Coexpression of TERT with proliferative cell nuclear antigen (PCNA) immunoreactivity is found in rod progenitor cells. These results suggest the role of telomerase in vertebrate central nervous system (CNS) other than telomere maintenance, such as regulation of cell cycle progression and maintenance of retinal cell phenotypes. © Humana Press Inc. 2007.en_HK
dc.languageengen_HK
dc.publisherHumana Press, Inc.en_HK
dc.relation.ispartofJournal of Molecular Neuroscienceen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshConsensus Sequenceen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGoldfish - geneticsen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshProtein Biosynthesisen_HK
dc.subject.meshRepetitive Sequences, Amino Aciden_HK
dc.subject.meshRetina - enzymologyen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTelomerase - geneticsen_HK
dc.titleExpression of telomerase reverse transcriptase in adult goldfish retinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0895-8696&volume=32&spage=160&epage=267&date=2007&atitle=Expression+of+telomerase+reverse+transcriptase+in+adult+goldfish+retinaen_HK
dc.identifier.emailTsao, GSW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.authorityTsao, GSW=rp00399en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12031-007-0031-6en_HK
dc.identifier.pmid17873300en_HK
dc.identifier.scopuseid_2-s2.0-34648823770en_HK
dc.identifier.hkuros141337en_HK
dc.identifier.hkuros160616-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34648823770&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue2en_HK
dc.identifier.spage160en_HK
dc.identifier.epage167en_HK
dc.identifier.isiWOS:000247833700008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridTsao, GSW=7102813116en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK

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