Article: Differential gene expression in nasopharyngeal carcinoma cells

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TitleDifferential gene expression in nasopharyngeal carcinoma cells
AuthorsFung, LF1
Lo, AKF1
Yuen, PW1
Liu, Y1
Wang, XH1
Tsao, SW1
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
CitationLife Sciences, 2000, v. 67 n. 8, p. 923-936 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0024-3205(00)00684-6
AbstractNasopharyngeal carcinoma (NPC) is a common cancer among southern Chinese. The profile of gene expression in NPC cells is largely unknown. In this study, we have examined differential gene expression in non-malignant and malignant nasopharyngeal epithelial (NPE) cells using a cDNA array hybridization method. A total of 42 genes were identified to be expressed in either non-malignant and malignant NPE cells or both. Thirteen of these genes were overexpressed in malignant NPE cells. These includes nuclear factor (NF90), FOS-related antigen 1 (FRA-1), cytoplasmic dynein light chain (HDLC1), replication factor C (RFC1), nucleoside diphosphate kinase B, UV excision repair protein (RAD23A), insulin-like growth factor receptor II, transcription initiation factor TFIID subunit (TAFII31), growth factor receptor-bound protein 2 (GRB2), UV excision repair protein (RAD23B), glutathione peroxidase. Y box binding protein 1 and heat shock protein 86. In contrast, expression of nine genes was suppressed in malignant NPE cells. These includes calgranulin A, calgranulin B, neutrophil activating protein (ENA-78), heat shock protein 27, integrin beta-1, integrin beta-4, cyclin- dependent kinase inhibitor 1A (p21), interleukin-8 and tyrosine protein kinase receptor (RET). Differential expression of calgranulin A, calgranulin B, ENA-78, FRA-1 and NF90 in non-malignant and malignant nasopharyngeal epithelial cells was confirmed by RT-PCR analysis. (C) 2000 Elsevier Science Inc.
ISSN0024-3205
2011 Impact Factor: 2.527
2011 SCImago Journal Rankings: 0.189
DOIhttp://dx.doi.org/10.1016/S0024-3205(00)00684-6
ISI Accession Number IDWOS:000088400500008
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorFung, LF
dc.contributor.authorLo, AKF
dc.contributor.authorYuen, PW
dc.contributor.authorLiu, Y
dc.contributor.authorWang, XH
dc.contributor.authorTsao, SW
dc.date.accessioned2010-09-06T05:57:20Z
dc.date.available2010-09-06T05:57:20Z
dc.date.issued2000
dc.description.abstractNasopharyngeal carcinoma (NPC) is a common cancer among southern Chinese. The profile of gene expression in NPC cells is largely unknown. In this study, we have examined differential gene expression in non-malignant and malignant nasopharyngeal epithelial (NPE) cells using a cDNA array hybridization method. A total of 42 genes were identified to be expressed in either non-malignant and malignant NPE cells or both. Thirteen of these genes were overexpressed in malignant NPE cells. These includes nuclear factor (NF90), FOS-related antigen 1 (FRA-1), cytoplasmic dynein light chain (HDLC1), replication factor C (RFC1), nucleoside diphosphate kinase B, UV excision repair protein (RAD23A), insulin-like growth factor receptor II, transcription initiation factor TFIID subunit (TAFII31), growth factor receptor-bound protein 2 (GRB2), UV excision repair protein (RAD23B), glutathione peroxidase. Y box binding protein 1 and heat shock protein 86. In contrast, expression of nine genes was suppressed in malignant NPE cells. These includes calgranulin A, calgranulin B, neutrophil activating protein (ENA-78), heat shock protein 27, integrin beta-1, integrin beta-4, cyclin- dependent kinase inhibitor 1A (p21), interleukin-8 and tyrosine protein kinase receptor (RET). Differential expression of calgranulin A, calgranulin B, ENA-78, FRA-1 and NF90 in non-malignant and malignant nasopharyngeal epithelial cells was confirmed by RT-PCR analysis. (C) 2000 Elsevier Science Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLife Sciences, 2000, v. 67 n. 8, p. 923-936 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0024-3205(00)00684-6
dc.identifier.doihttp://dx.doi.org/10.1016/S0024-3205(00)00684-6
dc.identifier.epage936
dc.identifier.hkuros52803
dc.identifier.isiWOS:000088400500008
dc.identifier.issn0024-3205
2011 Impact Factor: 2.527
2011 SCImago Journal Rankings: 0.189
dc.identifier.issue8
dc.identifier.openurl
dc.identifier.pmid10946852
dc.identifier.scopuseid_2-s2.0-0034647587
dc.identifier.spage923
dc.identifier.urihttp://hdl.handle.net/10722/67686
dc.identifier.volume67
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
dc.publisher.placeUnited States
dc.relation.ispartofLife Sciences
dc.relation.referencesReferences in Scopus
dc.rightsLife Sciences. Copyright © Elsevier Inc.
dc.subject.meshCalcium-Binding Proteins - genetics
dc.subject.meshCalgranulin A
dc.subject.meshCalgranulin B
dc.subject.meshChemokine CXCL5
dc.subject.meshChemokines, CXC
dc.subject.meshDNA, Complementary - analysis
dc.subject.meshDNA-Binding Proteins - genetics
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshHumans
dc.subject.meshInterleukin-8 - analogs & derivatives - genetics
dc.subject.meshNFATC Transcription Factors
dc.subject.meshNasopharyngeal Neoplasms - genetics
dc.subject.meshNasopharynx - metabolism
dc.subject.meshNuclear Factor 90 Proteins
dc.subject.meshNuclear Proteins
dc.subject.meshProto-Oncogene Proteins c-fos - genetics
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshTranscription Factors - genetics
dc.subject.meshTumor Cells, Cultured
dc.titleDifferential gene expression in nasopharyngeal carcinoma cells
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong