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Article: Differential gene expression in nasopharyngeal carcinoma cells
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TitleDifferential gene expression in nasopharyngeal carcinoma cells
 
AuthorsFung, LF1
Lo, AKF1
Yuen, PW1
Liu, Y1
Wang, XH1
Tsao, SW1
 
Issue Date2000
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
CitationLife Sciences, 2000, v. 67 n. 8, p. 923-936 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0024-3205(00)00684-6
 
AbstractNasopharyngeal carcinoma (NPC) is a common cancer among southern Chinese. The profile of gene expression in NPC cells is largely unknown. In this study, we have examined differential gene expression in non-malignant and malignant nasopharyngeal epithelial (NPE) cells using a cDNA array hybridization method. A total of 42 genes were identified to be expressed in either non-malignant and malignant NPE cells or both. Thirteen of these genes were overexpressed in malignant NPE cells. These includes nuclear factor (NF90), FOS-related antigen 1 (FRA-1), cytoplasmic dynein light chain (HDLC1), replication factor C (RFC1), nucleoside diphosphate kinase B, UV excision repair protein (RAD23A), insulin-like growth factor receptor II, transcription initiation factor TFIID subunit (TAFII31), growth factor receptor-bound protein 2 (GRB2), UV excision repair protein (RAD23B), glutathione peroxidase. Y box binding protein 1 and heat shock protein 86. In contrast, expression of nine genes was suppressed in malignant NPE cells. These includes calgranulin A, calgranulin B, neutrophil activating protein (ENA-78), heat shock protein 27, integrin beta-1, integrin beta-4, cyclin- dependent kinase inhibitor 1A (p21), interleukin-8 and tyrosine protein kinase receptor (RET). Differential expression of calgranulin A, calgranulin B, ENA-78, FRA-1 and NF90 in non-malignant and malignant nasopharyngeal epithelial cells was confirmed by RT-PCR analysis. (C) 2000 Elsevier Science Inc.
 
ISSN0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
DOIhttp://dx.doi.org/10.1016/S0024-3205(00)00684-6
 
ISI Accession Number IDWOS:000088400500008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorFung, LF
 
dc.contributor.authorLo, AKF
 
dc.contributor.authorYuen, PW
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorWang, XH
 
dc.contributor.authorTsao, SW
 
dc.date.accessioned2010-09-06T05:57:20Z
 
dc.date.available2010-09-06T05:57:20Z
 
dc.date.issued2000
 
dc.description.abstractNasopharyngeal carcinoma (NPC) is a common cancer among southern Chinese. The profile of gene expression in NPC cells is largely unknown. In this study, we have examined differential gene expression in non-malignant and malignant nasopharyngeal epithelial (NPE) cells using a cDNA array hybridization method. A total of 42 genes were identified to be expressed in either non-malignant and malignant NPE cells or both. Thirteen of these genes were overexpressed in malignant NPE cells. These includes nuclear factor (NF90), FOS-related antigen 1 (FRA-1), cytoplasmic dynein light chain (HDLC1), replication factor C (RFC1), nucleoside diphosphate kinase B, UV excision repair protein (RAD23A), insulin-like growth factor receptor II, transcription initiation factor TFIID subunit (TAFII31), growth factor receptor-bound protein 2 (GRB2), UV excision repair protein (RAD23B), glutathione peroxidase. Y box binding protein 1 and heat shock protein 86. In contrast, expression of nine genes was suppressed in malignant NPE cells. These includes calgranulin A, calgranulin B, neutrophil activating protein (ENA-78), heat shock protein 27, integrin beta-1, integrin beta-4, cyclin- dependent kinase inhibitor 1A (p21), interleukin-8 and tyrosine protein kinase receptor (RET). Differential expression of calgranulin A, calgranulin B, ENA-78, FRA-1 and NF90 in non-malignant and malignant nasopharyngeal epithelial cells was confirmed by RT-PCR analysis. (C) 2000 Elsevier Science Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLife Sciences, 2000, v. 67 n. 8, p. 923-936 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0024-3205(00)00684-6
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0024-3205(00)00684-6
 
dc.identifier.epage936
 
dc.identifier.hkuros52803
 
dc.identifier.isiWOS:000088400500008
 
dc.identifier.issn0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmid10946852
 
dc.identifier.scopuseid_2-s2.0-0034647587
 
dc.identifier.spage923
 
dc.identifier.urihttp://hdl.handle.net/10722/67686
 
dc.identifier.volume67
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
dc.publisher.placeUnited States
 
dc.relation.ispartofLife Sciences
 
dc.relation.referencesReferences in Scopus
 
dc.rightsLife Sciences. Copyright © Elsevier Inc.
 
dc.subject.meshCalcium-Binding Proteins - genetics
 
dc.subject.meshCalgranulin A
 
dc.subject.meshCalgranulin B
 
dc.subject.meshChemokine CXCL5
 
dc.subject.meshChemokines, CXC
 
dc.subject.meshDNA, Complementary - analysis
 
dc.subject.meshDNA-Binding Proteins - genetics
 
dc.subject.meshGene Expression Regulation, Neoplastic
 
dc.subject.meshHumans
 
dc.subject.meshInterleukin-8 - analogs & derivatives - genetics
 
dc.subject.meshNFATC Transcription Factors
 
dc.subject.meshNasopharyngeal Neoplasms - genetics
 
dc.subject.meshNasopharynx - metabolism
 
dc.subject.meshNuclear Factor 90 Proteins
 
dc.subject.meshNuclear Proteins
 
dc.subject.meshProto-Oncogene Proteins c-fos - genetics
 
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
 
dc.subject.meshTranscription Factors - genetics
 
dc.subject.meshTumor Cells, Cultured
 
dc.titleDifferential gene expression in nasopharyngeal carcinoma cells
 
dc.typeArticle
 
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<description.abstract>Nasopharyngeal carcinoma (NPC) is a common cancer among southern Chinese. The profile of gene expression in NPC cells is largely unknown. In this study, we have examined differential gene expression in non-malignant and malignant nasopharyngeal epithelial (NPE) cells using a cDNA array hybridization method. A total of 42 genes were identified to be expressed in either non-malignant and malignant NPE cells or both. Thirteen of these genes were overexpressed in malignant NPE cells. These includes nuclear factor (NF90), FOS-related antigen 1 (FRA-1), cytoplasmic dynein light chain (HDLC1), replication factor C (RFC1), nucleoside diphosphate kinase B, UV excision repair protein (RAD23A), insulin-like growth factor receptor II, transcription initiation factor TFIID subunit (TAFII31), growth factor receptor-bound protein 2 (GRB2), UV excision repair protein (RAD23B), glutathione peroxidase. Y box binding protein 1 and heat shock protein 86. In contrast, expression of nine genes was suppressed in malignant NPE cells. These includes calgranulin A, calgranulin B, neutrophil activating protein (ENA-78), heat shock protein 27, integrin beta-1, integrin beta-4, cyclin- dependent kinase inhibitor 1A (p21), interleukin-8 and tyrosine protein kinase receptor (RET). Differential expression of calgranulin A, calgranulin B, ENA-78, FRA-1 and NF90 in non-malignant and malignant nasopharyngeal epithelial cells was confirmed by RT-PCR analysis. (C) 2000 Elsevier Science Inc.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong