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Article: Long-term effects of a single dose of brain-derived neurotrophic factor on motoneuron survival following spinal root avulsion in the adult rat

TitleLong-term effects of a single dose of brain-derived neurotrophic factor on motoneuron survival following spinal root avulsion in the adult rat
Authors
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1999, v. 274 n. 3, p. 147-150 How to Cite?
AbstractThe long-term effect of a single dose of Brain-derived neurotrophic factor (BDNF) treatment on adult motoneuron survival and on expression of nitric oxide synthase (NOS) following nerve injury (avulsion) was investigated and compared with that of continuous BDNF treatment. By 6 weeks post-injury, more than 80% of motoneurons survived in animals treated with either a single dose or continuous treatment of BDNF, while only 30% of motoneurons survived in control animals (avulsion only). There were no significant differences in motoneuron survival between animals receiving a single dose and those with continuous treatment of BDNF. Additionally, the expression of NOS in avulsed motoneurons was almost completely inhibited in all BDNF treatment groups regardless of the mode of administration (single vs. continuous). These data indicate that treatment with a single dose of BDNF at the time of injury can inhibit NOS expression and provide the first evidence that in this situation BDNF has a long-term rescue effect on adult motoneuron survival after root avulsion. Copyright (C) 1999.
Persistent Identifierhttp://hdl.handle.net/10722/67681
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChai, Hen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorPrevette, DMen_HK
dc.contributor.authorOppenheim, RWen_HK
dc.date.accessioned2010-09-06T05:57:18Z-
dc.date.available2010-09-06T05:57:18Z-
dc.date.issued1999en_HK
dc.identifier.citationNeuroscience Letters, 1999, v. 274 n. 3, p. 147-150en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67681-
dc.description.abstractThe long-term effect of a single dose of Brain-derived neurotrophic factor (BDNF) treatment on adult motoneuron survival and on expression of nitric oxide synthase (NOS) following nerve injury (avulsion) was investigated and compared with that of continuous BDNF treatment. By 6 weeks post-injury, more than 80% of motoneurons survived in animals treated with either a single dose or continuous treatment of BDNF, while only 30% of motoneurons survived in control animals (avulsion only). There were no significant differences in motoneuron survival between animals receiving a single dose and those with continuous treatment of BDNF. Additionally, the expression of NOS in avulsed motoneurons was almost completely inhibited in all BDNF treatment groups regardless of the mode of administration (single vs. continuous). These data indicate that treatment with a single dose of BDNF at the time of injury can inhibit NOS expression and provide the first evidence that in this situation BDNF has a long-term rescue effect on adult motoneuron survival after root avulsion. Copyright (C) 1999.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain-Derived Neurotrophic Factor - pharmacologyen_HK
dc.subject.meshCell Counten_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshColoring Agentsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMotor Neurons - cytology - drug effects - enzymologyen_HK
dc.subject.meshNeutral Reden_HK
dc.subject.meshNitric Oxide Synthase - analysis - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSpinal Nerve Roots - cytology - injuriesen_HK
dc.titleLong-term effects of a single dose of brain-derived neurotrophic factor on motoneuron survival following spinal root avulsion in the adult raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=274&spage=147&epage=150&date=1999&atitle=Long-term+effects+of+a+single+dose+of+brain-derived+neurotrophic+factor+on+motoneuron+survival+following+spinal+root+avulsion+in+the+adult+raten_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3940(99)00671-0en_HK
dc.identifier.pmid10548411-
dc.identifier.scopuseid_2-s2.0-0032873649en_HK
dc.identifier.hkuros51519en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032873649&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume274en_HK
dc.identifier.issue3en_HK
dc.identifier.spage147en_HK
dc.identifier.epage150en_HK
dc.identifier.isiWOS:000083392300002-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChai, H=35918658800en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridPrevette, DM=7003628635en_HK
dc.identifier.scopusauthoridOppenheim, RW=7102628195en_HK

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