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Article: Synergistic effect of nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems

TitleSynergistic effect of nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems
Authors
Issue Date2004
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
Citation
Journal of Neurotrauma, 2004, v. 21 n. 5, p. 617-625 How to Cite?
AbstractThe presence of Nogo axon regeneration inhibitory molecules in the central nervous system (CNS) and the counteracting effect of IN-1 antibodies have been widely reported. In this study, we examined the effect of IN-1-producing hybridoma cells on axon regeneration in adult rodent retinal ganglion cells (RGCs) after various types of optic nerve (ON) injury, evaluating therein whether ciliary neurotrophic factor (CNTF) potentiated the effect of IN-1. We found that application of IN-1 alone failed to enhance regeneration of intracranially or intraorbitally transected RGC axons in a peripheral nerve (PN) graft. IN-1 hybridoma cells also failed to significantly promote intraorbitally crushed ON axons to reenter the distal part of the ON. However, a combined application of IN-1 and CNTF had a synergistic effect in both intracranial PN and intraorbital ON crush paradigms. This study suggests that the action of IN-1 antibodies in promoting axon regeneration in the CNS could be more effective when coupled with other appropriate factors.
Persistent Identifierhttp://hdl.handle.net/10722/67666
ISSN
2015 Impact Factor: 4.377
2015 SCImago Journal Rankings: 1.945
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCui, Qen_HK
dc.contributor.authorCho, KSen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKen_HK
dc.date.accessioned2010-09-06T05:57:10Z-
dc.date.available2010-09-06T05:57:10Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal of Neurotrauma, 2004, v. 21 n. 5, p. 617-625en_HK
dc.identifier.issn0897-7151en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67666-
dc.description.abstractThe presence of Nogo axon regeneration inhibitory molecules in the central nervous system (CNS) and the counteracting effect of IN-1 antibodies have been widely reported. In this study, we examined the effect of IN-1-producing hybridoma cells on axon regeneration in adult rodent retinal ganglion cells (RGCs) after various types of optic nerve (ON) injury, evaluating therein whether ciliary neurotrophic factor (CNTF) potentiated the effect of IN-1. We found that application of IN-1 alone failed to enhance regeneration of intracranially or intraorbitally transected RGC axons in a peripheral nerve (PN) graft. IN-1 hybridoma cells also failed to significantly promote intraorbitally crushed ON axons to reenter the distal part of the ON. However, a combined application of IN-1 and CNTF had a synergistic effect in both intracranial PN and intraorbital ON crush paradigms. This study suggests that the action of IN-1 antibodies in promoting axon regeneration in the CNS could be more effective when coupled with other appropriate factors.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neuen_HK
dc.relation.ispartofJournal of Neurotraumaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [Journal Of Neurotrauma] © [2004] [copyright Mary Ann Liebert, Inc.]; [Journal Of Neurotrauma] is available online at: http://www.liebertonline.com.-
dc.subject.meshAnimalsen_HK
dc.subject.meshAntibodies - pharmacologyen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCiliary Neurotrophic Factor - pharmacologyen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshDrug Synergismen_HK
dc.subject.meshMyelin Proteins - immunologyen_HK
dc.subject.meshNerve Crushen_HK
dc.subject.meshNerve Regeneration - drug effectsen_HK
dc.subject.meshOptic Nerve Injuries - drug therapyen_HK
dc.subject.meshPeroneal Nerve - transplantationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRetinal Ganglion Cells - drug effectsen_HK
dc.subject.meshTransplantsen_HK
dc.titleSynergistic effect of nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systemsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0897-7151&volume=21 no 5&spage=617&epage=625&date=2004&atitle=Synergistic+effect+of+nogo-neutralizing+antibody+IN-1+and+ciliary+neurotrophic+factor+on+axonal+regeneration+in+adult+rodent+visual+systemsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/089771504774129946en_HK
dc.identifier.pmid15165369-
dc.identifier.scopuseid_2-s2.0-2442645222en_HK
dc.identifier.hkuros87668en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442645222&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue5en_HK
dc.identifier.spage617en_HK
dc.identifier.epage625en_HK
dc.identifier.isiWOS:000221461900012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCui, Q=7103080164en_HK
dc.identifier.scopusauthoridCho, KS=7403956958en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK

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