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Article: Relationship between the mRNA transcriptions of bFGF and KGF in the carcinogenesis of oral mucosa
Title | Relationship between the mRNA transcriptions of bFGF and KGF in the carcinogenesis of oral mucosa |
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Authors | |
Issue Date | 1998 |
Publisher | Sichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/ |
Citation | Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 1998, v. 16 n. 1, p. 23-25 How to Cite? |
Abstract | The aim of the study was to determine the expressions and effects of KGF and bFGF of FGF superfamily in oral mucosa. The mRNA transcriptional levels of bFGF and KGF in dysplasia (DYS) and squamous cell carcinoma (SCC) of buccal mucosa were observed and evaluated by in situ hybridization method. The results showed that bFGF and KGF mRNA were expressed by the mesenchymal cells in both DYS and SCC groups, but not in any of the epithelial cells. The positive reactions were located in fibroblasts, endothelial cells and some of the chronic inflammatory cells. There is an increasing mRNA transcriptional level in SCC than in DYS. The results indicated that bFGF and KGF may not only enhance the neovascularization and formation of stroma by autocrine and paracrine action, but also involved in the growth of neoplastic cells. |
Persistent Identifier | http://hdl.handle.net/10722/67640 |
ISSN | 2023 SCImago Journal Rankings: 0.177 |
DC Field | Value | Language |
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dc.contributor.author | Jin, Y | en_HK |
dc.contributor.author | Deng, Z | en_HK |
dc.contributor.author | Tipoe, GL | en_HK |
dc.contributor.author | White, FH | en_HK |
dc.date.accessioned | 2010-09-06T05:56:56Z | - |
dc.date.available | 2010-09-06T05:56:56Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 1998, v. 16 n. 1, p. 23-25 | en_HK |
dc.identifier.issn | 1000-1182 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67640 | - |
dc.description.abstract | The aim of the study was to determine the expressions and effects of KGF and bFGF of FGF superfamily in oral mucosa. The mRNA transcriptional levels of bFGF and KGF in dysplasia (DYS) and squamous cell carcinoma (SCC) of buccal mucosa were observed and evaluated by in situ hybridization method. The results showed that bFGF and KGF mRNA were expressed by the mesenchymal cells in both DYS and SCC groups, but not in any of the epithelial cells. The positive reactions were located in fibroblasts, endothelial cells and some of the chronic inflammatory cells. There is an increasing mRNA transcriptional level in SCC than in DYS. The results indicated that bFGF and KGF may not only enhance the neovascularization and formation of stroma by autocrine and paracrine action, but also involved in the growth of neoplastic cells. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Sichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/ | en_HK |
dc.relation.ispartof | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology | en_HK |
dc.subject.mesh | Carcinoma, Squamous Cell - metabolism | en_HK |
dc.subject.mesh | Fibroblast Growth Factor 2 - biosynthesis - genetics | en_HK |
dc.subject.mesh | Fibroblast Growth Factor 7 | en_HK |
dc.subject.mesh | Fibroblast Growth Factors - biosynthesis - genetics | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | In Situ Hybridization | en_HK |
dc.subject.mesh | Keratinocytes - metabolism | en_HK |
dc.subject.mesh | Mouth Mucosa - metabolism | en_HK |
dc.subject.mesh | Mouth Neoplasms - metabolism | en_HK |
dc.subject.mesh | Precancerous Conditions - metabolism | en_HK |
dc.subject.mesh | RNA, Messenger - genetics | en_HK |
dc.title | Relationship between the mRNA transcriptions of bFGF and KGF in the carcinogenesis of oral mucosa | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1000-1182&volume=16&spage=23&epage=25&date=1998&atitle=Relationship+between+the+mRNA+transcriptions+of+bFGF+and+KGF+in+the+carcinogenesis+of+oral+mucosa | en_HK |
dc.identifier.email | Tipoe, GL:tgeorge@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tipoe, GL=rp00371 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.pmid | 12078175 | - |
dc.identifier.scopus | eid_2-s2.0-0031987494 | en_HK |
dc.identifier.hkuros | 32744 | en_HK |
dc.identifier.volume | 16 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 23 | en_HK |
dc.identifier.epage | 25 | en_HK |
dc.publisher.place | China | en_HK |
dc.identifier.scopusauthorid | Jin, Y=26643271200 | en_HK |
dc.identifier.scopusauthorid | Deng, Z=15119136700 | en_HK |
dc.identifier.scopusauthorid | Tipoe, GL=7003550610 | en_HK |
dc.identifier.scopusauthorid | White, FH=7202578907 | en_HK |
dc.identifier.issnl | 1000-1182 | - |