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Article: Relationship between the mRNA transcriptions of bFGF and KGF in the carcinogenesis of oral mucosa

TitleRelationship between the mRNA transcriptions of bFGF and KGF in the carcinogenesis of oral mucosa
Authors
Issue Date1998
PublisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/
Citation
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 1998, v. 16 n. 1, p. 23-25 How to Cite?
AbstractThe aim of the study was to determine the expressions and effects of KGF and bFGF of FGF superfamily in oral mucosa. The mRNA transcriptional levels of bFGF and KGF in dysplasia (DYS) and squamous cell carcinoma (SCC) of buccal mucosa were observed and evaluated by in situ hybridization method. The results showed that bFGF and KGF mRNA were expressed by the mesenchymal cells in both DYS and SCC groups, but not in any of the epithelial cells. The positive reactions were located in fibroblasts, endothelial cells and some of the chronic inflammatory cells. There is an increasing mRNA transcriptional level in SCC than in DYS. The results indicated that bFGF and KGF may not only enhance the neovascularization and formation of stroma by autocrine and paracrine action, but also involved in the growth of neoplastic cells.
Persistent Identifierhttp://hdl.handle.net/10722/67640
ISSN
2015 SCImago Journal Rankings: 0.121

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_HK
dc.contributor.authorDeng, Zen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorWhite, FHen_HK
dc.date.accessioned2010-09-06T05:56:56Z-
dc.date.available2010-09-06T05:56:56Z-
dc.date.issued1998en_HK
dc.identifier.citationHua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 1998, v. 16 n. 1, p. 23-25en_HK
dc.identifier.issn1000-1182en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67640-
dc.description.abstractThe aim of the study was to determine the expressions and effects of KGF and bFGF of FGF superfamily in oral mucosa. The mRNA transcriptional levels of bFGF and KGF in dysplasia (DYS) and squamous cell carcinoma (SCC) of buccal mucosa were observed and evaluated by in situ hybridization method. The results showed that bFGF and KGF mRNA were expressed by the mesenchymal cells in both DYS and SCC groups, but not in any of the epithelial cells. The positive reactions were located in fibroblasts, endothelial cells and some of the chronic inflammatory cells. There is an increasing mRNA transcriptional level in SCC than in DYS. The results indicated that bFGF and KGF may not only enhance the neovascularization and formation of stroma by autocrine and paracrine action, but also involved in the growth of neoplastic cells.en_HK
dc.languageengen_HK
dc.publisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/en_HK
dc.relation.ispartofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatologyen_HK
dc.subject.meshCarcinoma, Squamous Cell - metabolismen_HK
dc.subject.meshFibroblast Growth Factor 2 - biosynthesis - geneticsen_HK
dc.subject.meshFibroblast Growth Factor 7en_HK
dc.subject.meshFibroblast Growth Factors - biosynthesis - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshKeratinocytes - metabolismen_HK
dc.subject.meshMouth Mucosa - metabolismen_HK
dc.subject.meshMouth Neoplasms - metabolismen_HK
dc.subject.meshPrecancerous Conditions - metabolismen_HK
dc.subject.meshRNA, Messenger - geneticsen_HK
dc.titleRelationship between the mRNA transcriptions of bFGF and KGF in the carcinogenesis of oral mucosaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1000-1182&volume=16&spage=23&epage=25&date=1998&atitle=Relationship+between+the+mRNA+transcriptions+of+bFGF+and+KGF+in+the+carcinogenesis+of+oral+mucosaen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid12078175-
dc.identifier.scopuseid_2-s2.0-0031987494en_HK
dc.identifier.hkuros32744en_HK
dc.identifier.volume16en_HK
dc.identifier.issue1en_HK
dc.identifier.spage23en_HK
dc.identifier.epage25en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridJin, Y=26643271200en_HK
dc.identifier.scopusauthoridDeng, Z=15119136700en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridWhite, FH=7202578907en_HK

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