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Article: Up-regulation of circulating adhesion molecules in bronchiectasis

TitleUp-regulation of circulating adhesion molecules in bronchiectasis
Authors
KeywordsAdhesion molecules
Bronchiectasis
Neutrophils
Issue Date2000
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2000, v. 16 n. 4, p. 691-696 How to Cite?
AbstractAdhesion molecules are expressed on the surface of endothelial cells and leukocytes and are responsible for mediating the migration of intravascular leukocytes into inflamed tissue. Intensive recruitment of neutrophils into the airways occurs in bronchiectasis, although little is known about the role of adhesion molecules in this process. The authors, therefore, determined serum levels of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular adhesion molecule (VCAM)-1 in stable bronchiectasis patients (n=37) and healthy control subjects (n=17), and evaluated their relationship with clinical markers of disease severity in bronchiectasis. Serum levels of E-selectin, ICAM-1 and VCAM-1 in bronchiectasis patients were significantly higher than those in control subjects (p=0.02, <0.0001 and 0.0002 respectively). Both E-selectin and ICAM-1 levels were inversely related to forced expiratory volume in one second (FEV1)% predicted (r=-0.57, p<0.001; and r=-0.53, p=0.001 respectively), and FVC% predicted (r=-0.52, p=0.002; and r=-0.46, p=0.005). This was not the case for VCAM-1 levels. There was a correlation between serum ICAM-1 levels and 24 h sputum volume (r=-0.34, p= 0.04). Serum E-selectin and ICAM-1, but not VCAM-1, levels showed correlation with the number of lung lobes affected by bronchiectasis (r=0.35, p=0.04 and r=0.34, p=0.04 respectively). These original observations strongly suggest that E-selectin, intercellular adhesion molecule-1 and Vascular adhesion molecule-1 could play a significant role in the pathogenesis of bronchiectasis. (C) ERS Journals Ltd 2000.
Persistent Identifierhttp://hdl.handle.net/10722/67638
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_HK
dc.contributor.authorTipoe, Gen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorShum, IHen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorIp, MSen_HK
dc.contributor.authorTsang, KWen_HK
dc.date.accessioned2010-09-06T05:56:55Z-
dc.date.available2010-09-06T05:56:55Z-
dc.date.issued2000en_HK
dc.identifier.citationEuropean Respiratory Journal, 2000, v. 16 n. 4, p. 691-696en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67638-
dc.description.abstractAdhesion molecules are expressed on the surface of endothelial cells and leukocytes and are responsible for mediating the migration of intravascular leukocytes into inflamed tissue. Intensive recruitment of neutrophils into the airways occurs in bronchiectasis, although little is known about the role of adhesion molecules in this process. The authors, therefore, determined serum levels of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular adhesion molecule (VCAM)-1 in stable bronchiectasis patients (n=37) and healthy control subjects (n=17), and evaluated their relationship with clinical markers of disease severity in bronchiectasis. Serum levels of E-selectin, ICAM-1 and VCAM-1 in bronchiectasis patients were significantly higher than those in control subjects (p=0.02, <0.0001 and 0.0002 respectively). Both E-selectin and ICAM-1 levels were inversely related to forced expiratory volume in one second (FEV1)% predicted (r=-0.57, p<0.001; and r=-0.53, p=0.001 respectively), and FVC% predicted (r=-0.52, p=0.002; and r=-0.46, p=0.005). This was not the case for VCAM-1 levels. There was a correlation between serum ICAM-1 levels and 24 h sputum volume (r=-0.34, p= 0.04). Serum E-selectin and ICAM-1, but not VCAM-1, levels showed correlation with the number of lung lobes affected by bronchiectasis (r=0.35, p=0.04 and r=0.34, p=0.04 respectively). These original observations strongly suggest that E-selectin, intercellular adhesion molecule-1 and Vascular adhesion molecule-1 could play a significant role in the pathogenesis of bronchiectasis. (C) ERS Journals Ltd 2000.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectAdhesion moleculesen_HK
dc.subjectBronchiectasisen_HK
dc.subjectNeutrophilsen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBronchiectasis - blood - physiopathologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshE-Selectin - blooden_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshForced Expiratory Volumeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntercellular Adhesion Molecule-1 - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSputum - microbiologyen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshUp-Regulationen_HK
dc.subject.meshVascular Cell Adhesion Molecule-1 - blooden_HK
dc.subject.meshVital Capacityen_HK
dc.titleUp-regulation of circulating adhesion molecules in bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=16&issue=4&spage=691&epage=696&date=2000&atitle=Up-regulation+of+circulating+adhesion+molecules+in+bronchiectasisen_HK
dc.identifier.emailTipoe, G:tgeorge@hkucc.hku.hken_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.emailIp, MS:msmip@hku.hken_HK
dc.identifier.authorityTipoe, G=rp00371en_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.identifier.authorityIp, MS=rp00347en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1034/j.1399-3003.2000.16d21.xen_HK
dc.identifier.pmid11106214-
dc.identifier.scopuseid_2-s2.0-0033773010en_HK
dc.identifier.hkuros56439en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033773010&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage691en_HK
dc.identifier.epage696en_HK
dc.identifier.isiWOS:000165332000021-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridZheng, L=7403404086en_HK
dc.identifier.scopusauthoridTipoe, G=7003550610en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridShum, IH=6602960338en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridIp, MS=7102423259en_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK

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