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Article: Light delays synaptic deafferentation and potentiates the survival of axotomized retinal ganglion cells

TitleLight delays synaptic deafferentation and potentiates the survival of axotomized retinal ganglion cells
Authors
KeywordsCognitive rehabilitation
Environmental stimulation
Neuroprotection
Optic nerve transection
Synaptic deafferentation
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2006, v. 395 n. 3, p. 255-260 How to Cite?
AbstractKnowledge of the cellular mechanism underlying the therapeutic effect of stimulation and the optimal doses of such stimulation to maximize neuronal recovery is essential to guide clinical practice in neural rehabilitation. Using hamsters, we transected the optic nerve to demonstrate how light stimulation affects neuronal recovery. The c-fos protein was used as a neuronal connectivity marker. Here we show that: (a) in addition to cell death, a population of cells undergoes synaptic deafferentation and (b) light stimulation delays cell death and deafferentation. Among the three rearing conditions studied (6:18LD, 12:12LD, and 18:6LD), the 12:12LD condition appears to be the one achieving the optimal therapeutic effect. This study provides a solid base in the understanding of the neuroanatomical changes after traumatic brain injury and the need to establish an optimal level and timing for the environmental stimulation. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67635
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_HK
dc.contributor.authorHo, LSHen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorLee, TMCen_HK
dc.date.accessioned2010-09-06T05:56:53Z-
dc.date.available2010-09-06T05:56:53Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuroscience Letters, 2006, v. 395 n. 3, p. 255-260en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67635-
dc.description.abstractKnowledge of the cellular mechanism underlying the therapeutic effect of stimulation and the optimal doses of such stimulation to maximize neuronal recovery is essential to guide clinical practice in neural rehabilitation. Using hamsters, we transected the optic nerve to demonstrate how light stimulation affects neuronal recovery. The c-fos protein was used as a neuronal connectivity marker. Here we show that: (a) in addition to cell death, a population of cells undergoes synaptic deafferentation and (b) light stimulation delays cell death and deafferentation. Among the three rearing conditions studied (6:18LD, 12:12LD, and 18:6LD), the 12:12LD condition appears to be the one achieving the optimal therapeutic effect. This study provides a solid base in the understanding of the neuroanatomical changes after traumatic brain injury and the need to establish an optimal level and timing for the environmental stimulation. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectCognitive rehabilitationen_HK
dc.subjectEnvironmental stimulationen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectOptic nerve transectionen_HK
dc.subjectSynaptic deafferentationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCell Death - physiology - radiation effectsen_HK
dc.subject.meshCell Survival - physiology - radiation effectsen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshDose-Response Relationship, Radiationen_HK
dc.subject.meshLighten_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNeurons, Afferent - physiology - radiation effectsen_HK
dc.subject.meshNonlinear Dynamicsen_HK
dc.subject.meshOptic Nerve - physiologyen_HK
dc.subject.meshProto-Oncogene Proteins c-fos - biosynthesis - physiologyen_HK
dc.subject.meshRetinal Ganglion Cells - physiology - radiation effectsen_HK
dc.subject.meshSynapses - physiology - radiation effectsen_HK
dc.titleLight delays synaptic deafferentation and potentiates the survival of axotomized retinal ganglion cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=395&spage=255&epage=260&date=2006&atitle=Light+delays+synaptic+deafferentation+and+potentiates+the+survival+of+axotomized+retinal+ganglion+cells.+en_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2005.11.019en_HK
dc.identifier.pmid16352397-
dc.identifier.scopuseid_2-s2.0-32244443821en_HK
dc.identifier.hkuros130212en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32244443821&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume395en_HK
dc.identifier.issue3en_HK
dc.identifier.spage255en_HK
dc.identifier.epage260en_HK
dc.identifier.isiWOS:000235597800017-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridHo, LSH=36784947200en_HK
dc.identifier.scopusauthoridTay, DKC=7006796824en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK

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