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Article: GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats

TitleGDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats
Authors
Issue Date2003
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
Citation
Journal Of Neurotrauma, 2003, v. 20 n. 6, p. 603-612 How to Cite?
AbstractIn the present study, we examined the effects of glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and insulin growth factor (IGF-1) on adult motoneuron survival following spinal root avulsion. The expression of neuronal nitric oxide synthase (nNOS), c-Jun, and the low-affinity neurotrophin receptor (P75) following treatment with these neurotrophic factors was also examined. In control animals, approximately 80% of spinal motoneurons were nNOS positive at 3 weeks following the lesion, whereas in GDNF or BDNF treated animals no nNOS positive motoneurons were found at the same time point. Following injury and treatment with GDNF and BDNF increased numbers of motoneurons were c-Jun and P75 positive. By 6 weeks following the lesion, only approximately 28% of motoneurons persisted in control animals whereas about 90% of motoneurons survived injury following treatment with either GDNF or BDNF. In contrast, CNTF and IGF-1 were ineffective in either inhibiting nNOS expression or preventing motoneuron death. Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Persistent Identifierhttp://hdl.handle.net/10722/67622
ISSN
2015 Impact Factor: 4.377
2015 SCImago Journal Rankings: 1.945
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, Wen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorYick, LWen_HK
dc.contributor.authorChai, Hen_HK
dc.contributor.authorXie, Yen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorPrevette, DMen_HK
dc.contributor.authorOppenheim, RWen_HK
dc.date.accessioned2010-09-06T05:56:46Z-
dc.date.available2010-09-06T05:56:46Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Neurotrauma, 2003, v. 20 n. 6, p. 603-612en_HK
dc.identifier.issn0897-7151en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67622-
dc.description.abstractIn the present study, we examined the effects of glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and insulin growth factor (IGF-1) on adult motoneuron survival following spinal root avulsion. The expression of neuronal nitric oxide synthase (nNOS), c-Jun, and the low-affinity neurotrophin receptor (P75) following treatment with these neurotrophic factors was also examined. In control animals, approximately 80% of spinal motoneurons were nNOS positive at 3 weeks following the lesion, whereas in GDNF or BDNF treated animals no nNOS positive motoneurons were found at the same time point. Following injury and treatment with GDNF and BDNF increased numbers of motoneurons were c-Jun and P75 positive. By 6 weeks following the lesion, only approximately 28% of motoneurons persisted in control animals whereas about 90% of motoneurons survived injury following treatment with either GDNF or BDNF. In contrast, CNTF and IGF-1 were ineffective in either inhibiting nNOS expression or preventing motoneuron death. Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neuen_HK
dc.relation.ispartofJournal of Neurotraumaen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain-Derived Neurotrophic Factor - pharmacology - therapeutic useen_HK
dc.subject.meshCell Death - drug effects - physiologyen_HK
dc.subject.meshGene Expression Regulation - drug effects - physiologyen_HK
dc.subject.meshGlial Cell Line-Derived Neurotrophic Factoren_HK
dc.subject.meshMaleen_HK
dc.subject.meshMotor Neurons - drug effects - metabolism - pathologyen_HK
dc.subject.meshNerve Growth Factors - pharmacology - therapeutic useen_HK
dc.subject.meshNitric Oxide Synthase - biosynthesis - geneticsen_HK
dc.subject.meshNitric Oxide Synthase Type Ien_HK
dc.subject.meshProto-Oncogene Proteins c-jun - biosynthesis - geneticsen_HK
dc.subject.meshRadiculopathy - drug therapy - metabolism - pathologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor, Nerve Growth Factoren_HK
dc.subject.meshReceptors, Nerve Growth Factor - biosynthesis - geneticsen_HK
dc.titleGDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0897-7151&volume=20 No 6&spage=603&epage=612&date=2003&atitle=GDNF+and+BDNF+alter+the+expression+of+neuronal+NOS,+c-Jun,+and+p75+and+prevent+motoneuron+death+following+spinal+root+avulsion+in+adult+ratsen_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12906744-
dc.identifier.scopuseid_2-s2.0-0038045085en_HK
dc.identifier.hkuros85075en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038045085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue6en_HK
dc.identifier.spage603en_HK
dc.identifier.epage612en_HK
dc.identifier.isiWOS:000183926900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridLi, L=9038682000en_HK
dc.identifier.scopusauthoridYick, LW=6603414804en_HK
dc.identifier.scopusauthoridChai, H=35918658800en_HK
dc.identifier.scopusauthoridXie, Y=7403958873en_HK
dc.identifier.scopusauthoridYang, Y=8675011000en_HK
dc.identifier.scopusauthoridPrevette, DM=7003628635en_HK
dc.identifier.scopusauthoridOppenheim, RW=7102628195en_HK

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