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Article: Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice

TitleImpaired hepatocyte regeneration in toll-like receptor 4 mutant mice
Authors
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 2004, v. 49 n. 5, p. 843-849 How to Cite?
AbstractMultiple lines of evidence suggest a role for endogenous lipopolysaccharides in toxin-induced liver injury. Toll-like receptor 4 has recently been implicated as a cell surface receptor important for lipopolysaccharide responsiveness. In these experiments, we sought to determine the role of toll-like receptor 4 in acute liver injury by carbon tetrachloride by utilizing the naturally occurring toll-like receptor 4 mutant and wild-type mice strains. Mice were injected with either carbon tetrachloride or the carrier. Serum transaminase levels peaked at 24 hr after carbon tetrachloride administration for both wild-type and mutant mice, with no significant histological difference in initial liver injury between the two groups. However, an overall decrease in hepatocyte proliferation was found in the mutant mice. Examination of the liver tissue revealed significant decreases in intrahepatic expressions of proinflammatory mediators. In conclusion, our results suggest that toll-like receptor 4 is important in the hepatic regenerative response to CCl4 liver injury via its role in modulating the inflammatory response to hepatic injury.
Persistent Identifierhttp://hdl.handle.net/10722/67612
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSu, GLen_HK
dc.contributor.authorWang, SCen_HK
dc.contributor.authorAminlari, Aen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorSteinstraesser, Len_HK
dc.contributor.authorNanji, Aen_HK
dc.date.accessioned2010-09-06T05:56:41Z-
dc.date.available2010-09-06T05:56:41Z-
dc.date.issued2004en_HK
dc.identifier.citationDigestive Diseases And Sciences, 2004, v. 49 n. 5, p. 843-849en_HK
dc.identifier.issn0163-2116en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67612-
dc.description.abstractMultiple lines of evidence suggest a role for endogenous lipopolysaccharides in toxin-induced liver injury. Toll-like receptor 4 has recently been implicated as a cell surface receptor important for lipopolysaccharide responsiveness. In these experiments, we sought to determine the role of toll-like receptor 4 in acute liver injury by carbon tetrachloride by utilizing the naturally occurring toll-like receptor 4 mutant and wild-type mice strains. Mice were injected with either carbon tetrachloride or the carrier. Serum transaminase levels peaked at 24 hr after carbon tetrachloride administration for both wild-type and mutant mice, with no significant histological difference in initial liver injury between the two groups. However, an overall decrease in hepatocyte proliferation was found in the mutant mice. Examination of the liver tissue revealed significant decreases in intrahepatic expressions of proinflammatory mediators. In conclusion, our results suggest that toll-like receptor 4 is important in the hepatic regenerative response to CCl4 liver injury via its role in modulating the inflammatory response to hepatic injury.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_HK
dc.relation.ispartofDigestive Diseases and Sciencesen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCarbon Tetrachloride - adverse effectsen_HK
dc.subject.meshCytokines - biosynthesis - immunologyen_HK
dc.subject.meshDrug-Induced Liver Injury - etiology - immunologyen_HK
dc.subject.meshHepatocytes - immunologyen_HK
dc.subject.meshLiver Regeneration - immunologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Glycoproteins - immunologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Mutant Strainsen_HK
dc.subject.meshReceptors, Cell Surface - immunologyen_HK
dc.subject.meshSolvents - adverse effectsen_HK
dc.subject.meshToll-Like Receptorsen_HK
dc.titleImpaired hepatocyte regeneration in toll-like receptor 4 mutant miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-2116&volume=49&issue=5&spage=843&epage=849&date=2004&atitle=Impaired+hepatocyte+regeneration+in+toll-like+receptor+4+mutant+mice.en_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/B:DDAS.0000030097.52476.aaen_HK
dc.identifier.pmid15259507-
dc.identifier.scopuseid_2-s2.0-3042850186en_HK
dc.identifier.hkuros89430en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042850186&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue5en_HK
dc.identifier.spage843en_HK
dc.identifier.epage849en_HK
dc.identifier.isiWOS:000221847000021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSu, GL=7201359191en_HK
dc.identifier.scopusauthoridWang, SC=7410343879en_HK
dc.identifier.scopusauthoridAminlari, A=23059424400en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridSteinstraesser, L=6602581743en_HK
dc.identifier.scopusauthoridNanji, A=35885060300en_HK

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