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Article: Significance of TWIST expression and its association with E-cadherin in bladder cancer

TitleSignificance of TWIST expression and its association with E-cadherin in bladder cancer
Authors
KeywordsBladder cancer
E-cadherin
Metastasis
TWIST
Issue Date2007
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2007, v. 38 n. 4, p. 598-606 How to Cite?
AbstractRecently, TWIST, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of human cancer. The aim of this study was to investigate the significance of TWIST expression in bladder cancer using tissue microassays generated from 226 bladder tissue specimens. Using immunohistochemical staining, we studied TWIST expression levels in nonmalignant bladder tissues (n = 37), primary bladder cancer tissues (n = 164), and 25 cases of matched lymph node metastatic lesions. The association between TWIST expression levels and tumor staging and grading, as well as metastatic potential, was analyzed by statistical analysis. Our results showed that TWIST protein expression was significantly higher in bladder cancer specimens compared with nonmalignant tissues (P < .001), indicating its positive role in the development of bladder cancer. In addition, increased TWIST expression levels were associated with advanced-stage and high-grade tumors, suggesting its involvement in the progression of this cancer. Furthermore, TWIST expression was much higher in the metastatic lesion compared with its primary site (P < .05). More importantly, the increased TWIST expression in bladder cancer specimens was correlated with decreased membranous expression of E-cadherin, a cell adhesion molecule that plays a key role in the metastatic progression of human cancer. Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67608
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorXin, Den_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorChua, CWen_HK
dc.contributor.authorLeung, SCLen_HK
dc.contributor.authorNa, Yen_HK
dc.contributor.authorWang, Xen_HK
dc.date.accessioned2010-09-06T05:56:38Z-
dc.date.available2010-09-06T05:56:38Z-
dc.date.issued2007en_HK
dc.identifier.citationHuman Pathology, 2007, v. 38 n. 4, p. 598-606en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67608-
dc.description.abstractRecently, TWIST, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of human cancer. The aim of this study was to investigate the significance of TWIST expression in bladder cancer using tissue microassays generated from 226 bladder tissue specimens. Using immunohistochemical staining, we studied TWIST expression levels in nonmalignant bladder tissues (n = 37), primary bladder cancer tissues (n = 164), and 25 cases of matched lymph node metastatic lesions. The association between TWIST expression levels and tumor staging and grading, as well as metastatic potential, was analyzed by statistical analysis. Our results showed that TWIST protein expression was significantly higher in bladder cancer specimens compared with nonmalignant tissues (P < .001), indicating its positive role in the development of bladder cancer. In addition, increased TWIST expression levels were associated with advanced-stage and high-grade tumors, suggesting its involvement in the progression of this cancer. Furthermore, TWIST expression was much higher in the metastatic lesion compared with its primary site (P < .05). More importantly, the increased TWIST expression in bladder cancer specimens was correlated with decreased membranous expression of E-cadherin, a cell adhesion molecule that plays a key role in the metastatic progression of human cancer. Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectBladder canceren_HK
dc.subjectE-cadherinen_HK
dc.subjectMetastasisen_HK
dc.subjectTWISTen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCadherins - biosynthesisen_HK
dc.subject.meshDown-Regulationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLymphatic Metastasis - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNuclear Proteins - biosynthesisen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshTumor Markers, Biological - biosynthesisen_HK
dc.subject.meshTwist Transcription Factor - biosynthesisen_HK
dc.subject.meshUp-Regulationen_HK
dc.subject.meshUrinary Bladder Neoplasms - metabolism - pathologyen_HK
dc.titleSignificance of TWIST expression and its association with E-cadherin in bladder canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=38&spage=598&epage=606&date=2007&atitle=Significance+of+TWIST+expression+and+its+association+with+E-cadherin+in+bladder+cancer.en_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2006.10.004en_HK
dc.identifier.pmid17258791-
dc.identifier.scopuseid_2-s2.0-33947129096en_HK
dc.identifier.hkuros138963en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947129096&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue4en_HK
dc.identifier.spage598en_HK
dc.identifier.epage606en_HK
dc.identifier.isiWOS:000245319800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, Z=8702208300en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridLi, X=36065691100en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridXin, D=7006327751en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridChua, CW=9437494600en_HK
dc.identifier.scopusauthoridLeung, SCL=36894169100en_HK
dc.identifier.scopusauthoridNa, Y=7006088519en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK

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