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- PMID: 17258791
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Article: Significance of TWIST expression and its association with E-cadherin in bladder cancer
Title | Significance of TWIST expression and its association with E-cadherin in bladder cancer |
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Authors | |
Keywords | Bladder cancer E-cadherin Metastasis TWIST |
Issue Date | 2007 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath |
Citation | Human Pathology, 2007, v. 38 n. 4, p. 598-606 How to Cite? |
Abstract | Recently, TWIST, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of human cancer. The aim of this study was to investigate the significance of TWIST expression in bladder cancer using tissue microassays generated from 226 bladder tissue specimens. Using immunohistochemical staining, we studied TWIST expression levels in nonmalignant bladder tissues (n = 37), primary bladder cancer tissues (n = 164), and 25 cases of matched lymph node metastatic lesions. The association between TWIST expression levels and tumor staging and grading, as well as metastatic potential, was analyzed by statistical analysis. Our results showed that TWIST protein expression was significantly higher in bladder cancer specimens compared with nonmalignant tissues (P < .001), indicating its positive role in the development of bladder cancer. In addition, increased TWIST expression levels were associated with advanced-stage and high-grade tumors, suggesting its involvement in the progression of this cancer. Furthermore, TWIST expression was much higher in the metastatic lesion compared with its primary site (P < .05). More importantly, the increased TWIST expression in bladder cancer specimens was correlated with decreased membranous expression of E-cadherin, a cell adhesion molecule that plays a key role in the metastatic progression of human cancer. Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/67608 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.936 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Z | en_HK |
dc.contributor.author | Xie, D | en_HK |
dc.contributor.author | Li, X | en_HK |
dc.contributor.author | Wong, YC | en_HK |
dc.contributor.author | Xin, D | en_HK |
dc.contributor.author | Guan, XY | en_HK |
dc.contributor.author | Chua, CW | en_HK |
dc.contributor.author | Leung, SCL | en_HK |
dc.contributor.author | Na, Y | en_HK |
dc.contributor.author | Wang, X | en_HK |
dc.date.accessioned | 2010-09-06T05:56:38Z | - |
dc.date.available | 2010-09-06T05:56:38Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Human Pathology, 2007, v. 38 n. 4, p. 598-606 | en_HK |
dc.identifier.issn | 0046-8177 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67608 | - |
dc.description.abstract | Recently, TWIST, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of human cancer. The aim of this study was to investigate the significance of TWIST expression in bladder cancer using tissue microassays generated from 226 bladder tissue specimens. Using immunohistochemical staining, we studied TWIST expression levels in nonmalignant bladder tissues (n = 37), primary bladder cancer tissues (n = 164), and 25 cases of matched lymph node metastatic lesions. The association between TWIST expression levels and tumor staging and grading, as well as metastatic potential, was analyzed by statistical analysis. Our results showed that TWIST protein expression was significantly higher in bladder cancer specimens compared with nonmalignant tissues (P < .001), indicating its positive role in the development of bladder cancer. In addition, increased TWIST expression levels were associated with advanced-stage and high-grade tumors, suggesting its involvement in the progression of this cancer. Furthermore, TWIST expression was much higher in the metastatic lesion compared with its primary site (P < .05). More importantly, the increased TWIST expression in bladder cancer specimens was correlated with decreased membranous expression of E-cadherin, a cell adhesion molecule that plays a key role in the metastatic progression of human cancer. Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer. © 2007 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath | en_HK |
dc.relation.ispartof | Human Pathology | en_HK |
dc.subject | Bladder cancer | en_HK |
dc.subject | E-cadherin | en_HK |
dc.subject | Metastasis | en_HK |
dc.subject | TWIST | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Cadherins - biosynthesis | en_HK |
dc.subject.mesh | Down-Regulation | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Lymphatic Metastasis - physiopathology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Nuclear Proteins - biosynthesis | en_HK |
dc.subject.mesh | RNA, Messenger - metabolism | en_HK |
dc.subject.mesh | Tumor Markers, Biological - biosynthesis | en_HK |
dc.subject.mesh | Twist Transcription Factor - biosynthesis | en_HK |
dc.subject.mesh | Up-Regulation | en_HK |
dc.subject.mesh | Urinary Bladder Neoplasms - metabolism - pathology | en_HK |
dc.title | Significance of TWIST expression and its association with E-cadherin in bladder cancer | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=38&spage=598&epage=606&date=2007&atitle=Significance+of+TWIST+expression+and+its+association+with+E-cadherin+in+bladder+cancer. | en_HK |
dc.identifier.email | Wong, YC:ycwong@hkucc.hku.hk | en_HK |
dc.identifier.email | Guan, XY:xyguan@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wong, YC=rp00316 | en_HK |
dc.identifier.authority | Guan, XY=rp00454 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.humpath.2006.10.004 | en_HK |
dc.identifier.pmid | 17258791 | - |
dc.identifier.scopus | eid_2-s2.0-33947129096 | en_HK |
dc.identifier.hkuros | 138963 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33947129096&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 38 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 598 | en_HK |
dc.identifier.epage | 606 | en_HK |
dc.identifier.isi | WOS:000245319800010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zhang, Z=8702208300 | en_HK |
dc.identifier.scopusauthorid | Xie, D=35070710200 | en_HK |
dc.identifier.scopusauthorid | Li, X=36065691100 | en_HK |
dc.identifier.scopusauthorid | Wong, YC=7403041798 | en_HK |
dc.identifier.scopusauthorid | Xin, D=7006327751 | en_HK |
dc.identifier.scopusauthorid | Guan, XY=7201463221 | en_HK |
dc.identifier.scopusauthorid | Chua, CW=9437494600 | en_HK |
dc.identifier.scopusauthorid | Leung, SCL=36894169100 | en_HK |
dc.identifier.scopusauthorid | Na, Y=7006088519 | en_HK |
dc.identifier.scopusauthorid | Wang, X=7501854829 | en_HK |
dc.identifier.issnl | 0046-8177 | - |