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Article: Using nanotechnology to design potential therapies for CNS regeneration

TitleUsing nanotechnology to design potential therapies for CNS regeneration
Authors
KeywordsBlood brain barrier
CNS
Imaging
Nanomaterials
Nanomedicine
Nanotechnology
Regeneration
Issue Date2007
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htm
Citation
Current Pharmaceutical Design, 2007, v. 13 n. 24, p. 2519-2528 How to Cite?
AbstractThe nanodelivery of therapeutics into the brain will require a step-change in thinking; overcoming the blood brain barrier is one of the major challenges to any neural therapy. The promise of nanotechnology is that the selective delivery of therapeutics can be delivered through to the brain without causing secondary damage. There are several formidable barriers that must be overcome in order to achieve axonal regeneration after injury in the CNS. The development of new biological materials, in particular biologically compatible scaffolds that can serve as permissive substrates for cell growth, differentiation and biological function is a key area for advancing medical technology. This review focuses on four areas: First, the barriers of delivering therapies to the central nervous system and how nanotechnology can potentially solve them; second, current research in neuro nanomedicine featuring brain repair, brain imaging, nanomachines, protein misfolding diseases, nanosurgery, implanted devices and nanotechnologies for crossing the blood brain barrier, third, health and safety issues and fourth, the future of neuro nanomedicine as it relates to the pharmaceutical industry. © 2007 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/67599
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.220
References

 

DC FieldValueLanguage
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorTeather, LAen_HK
dc.contributor.authorSchneider, GEen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:56:33Z-
dc.date.available2010-09-06T05:56:33Z-
dc.date.issued2007en_HK
dc.identifier.citationCurrent Pharmaceutical Design, 2007, v. 13 n. 24, p. 2519-2528en_HK
dc.identifier.issn1381-6128en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67599-
dc.description.abstractThe nanodelivery of therapeutics into the brain will require a step-change in thinking; overcoming the blood brain barrier is one of the major challenges to any neural therapy. The promise of nanotechnology is that the selective delivery of therapeutics can be delivered through to the brain without causing secondary damage. There are several formidable barriers that must be overcome in order to achieve axonal regeneration after injury in the CNS. The development of new biological materials, in particular biologically compatible scaffolds that can serve as permissive substrates for cell growth, differentiation and biological function is a key area for advancing medical technology. This review focuses on four areas: First, the barriers of delivering therapies to the central nervous system and how nanotechnology can potentially solve them; second, current research in neuro nanomedicine featuring brain repair, brain imaging, nanomachines, protein misfolding diseases, nanosurgery, implanted devices and nanotechnologies for crossing the blood brain barrier, third, health and safety issues and fourth, the future of neuro nanomedicine as it relates to the pharmaceutical industry. © 2007 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htmen_HK
dc.relation.ispartofCurrent Pharmaceutical Designen_HK
dc.subjectBlood brain barrieren_HK
dc.subjectCNSen_HK
dc.subjectImagingen_HK
dc.subjectNanomaterialsen_HK
dc.subjectNanomedicineen_HK
dc.subjectNanotechnologyen_HK
dc.subjectRegenerationen_HK
dc.titleUsing nanotechnology to design potential therapies for CNS regenerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1381-6128&volume=13&issue=24&spage=2519&epage=2538&date=2007&atitle=Using+Nanotechnology+To+Design+Potential+Therapies+For+CNS+Regenerationen_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/138161207781368648en_HK
dc.identifier.pmid17692020-
dc.identifier.scopuseid_2-s2.0-34548450759en_HK
dc.identifier.hkuros135289en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548450759&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue24en_HK
dc.identifier.spage2519en_HK
dc.identifier.epage2528en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridTeather, LA=6602829059en_HK
dc.identifier.scopusauthoridSchneider, GE=55057824300en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.citeulike1511274-

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