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Article: Effects of a therapeutic laser on the ultrastructural morphology of repairing medial collateral ligament in a rat model

TitleEffects of a therapeutic laser on the ultrastructural morphology of repairing medial collateral ligament in a rat model
Authors
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34073
Citation
Lasers In Surgery And Medicine, 2003, v. 32 n. 4, p. 286-293 How to Cite?
AbstractBackground and Objectives: Low energy laser therapy has been shown to enhance mechanical strength of healing medial collateral ligament (MCL) in rats. The present study investigated its effects on the ultrastructural morphology and collagen fibril profile of healing MCL in rats. Study Design/Materials and Methods: Thirty-two mature male Sprague-Dawley (SD) rats were used. Twenty-four underwent surgical transection to their right MCLs and eight received only skin wound. Immediately after surgery, eight of the MCL transected rats were treated with a single dose of laser therapy at 63.2 J cm-2, eight were treated with a single dose of laser therapy at 31.6 J cm-2, the rest had no treatment and served as control. At 3 and 6 weeks after surgery, the MCLs were harvested and examined with electron microscopy for collagen fibril size, distribution, and alignment. Results: Significant differences (P < 0.001) were found in fibril diameters from the same anatomical site and time period among different groups. The mass-averaged diameters of the laser-treated (64.99-186.29 nm) and sham (64.74-204.34 nm) groups were larger than the control group (58.66-85.89 nm). The collagen fibrils occupied 42.55-59.78, 42.63-53.94, and 36.92-71:64% of the total cross-sectional areas in the laser-treated, control and sham groups, respectively. Mode obliquity was 0.53-0.84 among the three groups. Conclusions: Single application of low energy laser therapy increases the collagen fibril size of healing MCLs in rats. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67597
ISSN
2015 Impact Factor: 2.135
2015 SCImago Journal Rankings: 0.977
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFung, DTCen_HK
dc.contributor.authorNg, GYFen_HK
dc.contributor.authorLeung, MCPen_HK
dc.contributor.authorTay, DKCen_HK
dc.date.accessioned2010-09-06T05:56:32Z-
dc.date.available2010-09-06T05:56:32Z-
dc.date.issued2003en_HK
dc.identifier.citationLasers In Surgery And Medicine, 2003, v. 32 n. 4, p. 286-293en_HK
dc.identifier.issn0196-8092en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67597-
dc.description.abstractBackground and Objectives: Low energy laser therapy has been shown to enhance mechanical strength of healing medial collateral ligament (MCL) in rats. The present study investigated its effects on the ultrastructural morphology and collagen fibril profile of healing MCL in rats. Study Design/Materials and Methods: Thirty-two mature male Sprague-Dawley (SD) rats were used. Twenty-four underwent surgical transection to their right MCLs and eight received only skin wound. Immediately after surgery, eight of the MCL transected rats were treated with a single dose of laser therapy at 63.2 J cm-2, eight were treated with a single dose of laser therapy at 31.6 J cm-2, the rest had no treatment and served as control. At 3 and 6 weeks after surgery, the MCLs were harvested and examined with electron microscopy for collagen fibril size, distribution, and alignment. Results: Significant differences (P < 0.001) were found in fibril diameters from the same anatomical site and time period among different groups. The mass-averaged diameters of the laser-treated (64.99-186.29 nm) and sham (64.74-204.34 nm) groups were larger than the control group (58.66-85.89 nm). The collagen fibrils occupied 42.55-59.78, 42.63-53.94, and 36.92-71:64% of the total cross-sectional areas in the laser-treated, control and sham groups, respectively. Mode obliquity was 0.53-0.84 among the three groups. Conclusions: Single application of low energy laser therapy increases the collagen fibril size of healing MCLs in rats. © 2003 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34073en_HK
dc.relation.ispartofLasers in Surgery and Medicineen_HK
dc.rightsLasers in Surgery and Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCollagen - ultrastructureen_HK
dc.subject.meshLaser Therapy, Low-Levelen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMedial Collateral Ligament, Knee - injuries - ultrastructureen_HK
dc.subject.meshMicroscopy, Electronen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshWound Healing - radiation effectsen_HK
dc.titleEffects of a therapeutic laser on the ultrastructural morphology of repairing medial collateral ligament in a rat modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0196-8092&volume=32&spage=286&epage=293&date=2003&atitle=Effects+of+a+therapeutic+laser+on+the+ultrastructural+morphology+of+repairing+medial+collateral+ligament+in+a+rat+modelen_HK
dc.identifier.emailTay, DKC:dkctay@hkucc.hku.hken_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/lsm.10161en_HK
dc.identifier.pmid12696096-
dc.identifier.scopuseid_2-s2.0-0037624903en_HK
dc.identifier.hkuros79946en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037624903&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue4en_HK
dc.identifier.spage286en_HK
dc.identifier.epage293en_HK
dc.identifier.isiWOS:000182641400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFung, DTC=7103139877en_HK
dc.identifier.scopusauthoridNg, GYF=7102563754en_HK
dc.identifier.scopusauthoridLeung, MCP=7201943351en_HK
dc.identifier.scopusauthoridTay, DKC=7006796825en_HK

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