File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult rats

TitleA subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult rats
Authors
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2007, v. 1159 n. 1, p. 18-27 How to Cite?
AbstractIntermediate filaments (IFs) of nestin and vimentin are expressed in immature astrocytes. In this study, we examined the re-expression of these early glial traits in rat reactive astrocytes in affected neuronal perikarya in supraoptic (SON) and paraventricular (PVN) nuclei induced by hypophysectomy. Double-labeling immunofluorescence confocal laser microscopy demonstrated that by 7 days post-lesion, both nestin and vimentin were present intensely in hypertrophied GFAP-IR reactive astrocytes in the area of hypophysectomized magnocellular neurons in SON and PVN, while nestin and vimentin are absent in the normal or sham-operated animals. As the gliotic reaction progressed, the morphology of nestin or vimentin-positive reactive astrocytes in SON but not PVN changed from stellate form at 7 days to thin and elongated shape, morphologically compatible with radial glia during development, at 14 days post-lesion. By 28 days post-lesion, while vimentin-IR persisted in reactive astrocytes in SON and PVN, nestin-IR could hardly be detected. The spatiotemporal pattern of nestin-IR and/or vimentin-IR in reactive astrocytes suggests astrocytes attempt to revert to a more primitive glia form indicated by changes in morphology and phenotype following hypophysectomy, which may contribute to neuronal trophism and plasticity in the lesioned HNS favoring neuronal maintenance and fiber outgrowth. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67582
ISSN
2014 Impact Factor: 2.843
2013 SCImago Journal Rankings: 1.572
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorScott, DEen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:56:25Z-
dc.date.available2010-09-06T05:56:25Z-
dc.date.issued2007en_HK
dc.identifier.citationBrain Research, 2007, v. 1159 n. 1, p. 18-27en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67582-
dc.description.abstractIntermediate filaments (IFs) of nestin and vimentin are expressed in immature astrocytes. In this study, we examined the re-expression of these early glial traits in rat reactive astrocytes in affected neuronal perikarya in supraoptic (SON) and paraventricular (PVN) nuclei induced by hypophysectomy. Double-labeling immunofluorescence confocal laser microscopy demonstrated that by 7 days post-lesion, both nestin and vimentin were present intensely in hypertrophied GFAP-IR reactive astrocytes in the area of hypophysectomized magnocellular neurons in SON and PVN, while nestin and vimentin are absent in the normal or sham-operated animals. As the gliotic reaction progressed, the morphology of nestin or vimentin-positive reactive astrocytes in SON but not PVN changed from stellate form at 7 days to thin and elongated shape, morphologically compatible with radial glia during development, at 14 days post-lesion. By 28 days post-lesion, while vimentin-IR persisted in reactive astrocytes in SON and PVN, nestin-IR could hardly be detected. The spatiotemporal pattern of nestin-IR and/or vimentin-IR in reactive astrocytes suggests astrocytes attempt to revert to a more primitive glia form indicated by changes in morphology and phenotype following hypophysectomy, which may contribute to neuronal trophism and plasticity in the lesioned HNS favoring neuronal maintenance and fiber outgrowth. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshArginine Vasopressin - metabolismen_HK
dc.subject.meshAstrocytes - classification - metabolismen_HK
dc.subject.meshBromodeoxyuridine - metabolismen_HK
dc.subject.meshGene Expression Regulation - physiologyen_HK
dc.subject.meshGlial Fibrillary Acidic Protein - metabolismen_HK
dc.subject.meshHypophysectomyen_HK
dc.subject.meshIntermediate Filament Proteins - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNerve Tissue Proteins - metabolismen_HK
dc.subject.meshNeurons - metabolismen_HK
dc.subject.meshParaventricular Hypothalamic Nucleus - cytologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSupraoptic Nucleus - cytologyen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshVimentin - metabolismen_HK
dc.titleA subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=1159&spage=18&epage=27&date=2007&atitle=A+subpopulation+of+reactive+astrocytes+at+affected+neuronal+perikarya+after+hypophysectomy+in+adult+ratsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2007.04.084en_HK
dc.identifier.pmid17573051en_HK
dc.identifier.scopuseid_2-s2.0-34447299935en_HK
dc.identifier.hkuros135156en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447299935&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1159en_HK
dc.identifier.issue1en_HK
dc.identifier.spage18en_HK
dc.identifier.epage27en_HK
dc.identifier.isiWOS:000248614100003-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridYuan, Q=7202814773en_HK
dc.identifier.scopusauthoridScott, DE=7404951677en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats