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Article: Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes

TitleEffects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes
Authors
Issue Date2001
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuint
Citation
Neurochemistry International, 2001, v. 38 n. 3, p. 249-254 How to Cite?
AbstractTaurine is known to play a major role in volume regulation in astrocytic swelling associated with stroke and brain trauma. Apart from brain edema, the severity of brain injury is related to the levels of inflammatory cytokines such as tumor necrosis factor α (TNFα). TNFα had been shown to be closely associated with brain edema formation since the neutralization of TNFα reduced brain edema. Considering taurine has osmoregulatory functions in astrocytes, experiments were performed to study the effects of TNFα on taurine uptake in cultured astrocytes. Astrocytes exposed to 20 ng/ml of TNFα for 48 h showed a 91% increase in taurine uptake and significant increase was observed after 24 h exposure. This cytokine caused neither significant changes in cell volume nor taurine release. The increased in taurine uptake induced by TNFα was unlikely resulted from the modification of Na+ movement because TNFα decreased tyrosine uptake, Na+-dependent transport system. In contrast to TNFα, interferon-γ (IFNγ) did not significantly affect taurine uptake. Taken together, our results did not support a suggestion that TNFα affects cell volume regulation via modulating taurine uptake in astrocytes. Increasing lines of evidence have demonstrated that taurine has anti-inflammatory and anti-oxidative effects, these findings therefore suggested that the increase in taurine uptake might be an adaptive response or a tool for astrocytes against oxidative stress. (C) 2001 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/67574
ISSN
2015 Impact Factor: 3.385
2015 SCImago Journal Rankings: 1.345
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorStadlin, Aen_HK
dc.contributor.authorTsang, Den_HK
dc.date.accessioned2010-09-06T05:56:21Z-
dc.date.available2010-09-06T05:56:21Z-
dc.date.issued2001en_HK
dc.identifier.citationNeurochemistry International, 2001, v. 38 n. 3, p. 249-254en_HK
dc.identifier.issn0197-0186en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67574-
dc.description.abstractTaurine is known to play a major role in volume regulation in astrocytic swelling associated with stroke and brain trauma. Apart from brain edema, the severity of brain injury is related to the levels of inflammatory cytokines such as tumor necrosis factor α (TNFα). TNFα had been shown to be closely associated with brain edema formation since the neutralization of TNFα reduced brain edema. Considering taurine has osmoregulatory functions in astrocytes, experiments were performed to study the effects of TNFα on taurine uptake in cultured astrocytes. Astrocytes exposed to 20 ng/ml of TNFα for 48 h showed a 91% increase in taurine uptake and significant increase was observed after 24 h exposure. This cytokine caused neither significant changes in cell volume nor taurine release. The increased in taurine uptake induced by TNFα was unlikely resulted from the modification of Na+ movement because TNFα decreased tyrosine uptake, Na+-dependent transport system. In contrast to TNFα, interferon-γ (IFNγ) did not significantly affect taurine uptake. Taken together, our results did not support a suggestion that TNFα affects cell volume regulation via modulating taurine uptake in astrocytes. Increasing lines of evidence have demonstrated that taurine has anti-inflammatory and anti-oxidative effects, these findings therefore suggested that the increase in taurine uptake might be an adaptive response or a tool for astrocytes against oxidative stress. (C) 2001 Elsevier Science Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuinten_HK
dc.relation.ispartofNeurochemistry Internationalen_HK
dc.rightsNeurochemistry International. Copyright © Elsevier Ltd.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAstrocytes - cytology - drug effects - metabolismen_HK
dc.subject.meshCell Size - drug effectsen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshInterferon-gamma - pharmacologyen_HK
dc.subject.meshLipopolysaccharides - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTaurine - metabolism - pharmacokineticsen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTumor Necrosis Factor-alpha - pharmacologyen_HK
dc.subject.meshTyrosine - pharmacokineticsen_HK
dc.titleEffects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-0186&volume=38&spage=249&epage=254&date=2001&atitle=Effects+of+tumor+necrosis+factor+alpha+on+taurine+uptake+in+cultured+rat+astrocytesen_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0197-0186(00)00082-6en_HK
dc.identifier.pmid11099784-
dc.identifier.scopuseid_2-s2.0-0035195680en_HK
dc.identifier.hkuros64011en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035195680&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage249en_HK
dc.identifier.epage254en_HK
dc.identifier.isiWOS:000166890300009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridStadlin, A=6602676624en_HK
dc.identifier.scopusauthoridTsang, D=7005609135en_HK

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