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Article: Identification of a specifically expressed modified form of novel PSP-94 protein in the secretion of benign prostatic hyperplasia

TitleIdentification of a specifically expressed modified form of novel PSP-94 protein in the secretion of benign prostatic hyperplasia
Authors
Issue Date2003
PublisherWiley - V C H Verlag GmbH & Co KGaA.
Citation
Electrophoresis, 2003, v. 24 n. 7-8, p. 1311-1318 How to Cite?
AbstractUsing two-dimensional gel electrophoresis, we investigated the profile of prostatic secretory proteins in human expressed prostatic secretion (EPS) from benign prostate hyperplasia (BPH) patients and compared the patterns with normal controls. We identified three specifically expressed proteins, including prostate secretory protein 61 (PSP61), in EPS from benign BPH patients but absent in normal controls. In addition, we found that PSP61 was a modified isoform of the well-documented PSP-94, which had a perfect matching (100% homology) to the first 61 amino acids of the PSP-94 protein but with a deleted C-terminus. This shortened PSP61 was not due to alternative splicing of the PSP-94 gene at transcription level. Our results provide first evidence on the possibility of using PSP61 as a specific biological marker for diagnosis of BPH.
Persistent Identifierhttp://hdl.handle.net/10722/67570
ISSN
2015 Impact Factor: 2.482
2015 SCImago Journal Rankings: 0.896
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Ken_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorLing, MTen_HK
dc.contributor.authorLee, DTWen_HK
dc.contributor.authorFan, Ten_HK
dc.contributor.authorChan, FLen_HK
dc.contributor.authorXuan, JJWen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorWong, YCen_HK
dc.date.accessioned2010-09-06T05:56:18Z-
dc.date.available2010-09-06T05:56:18Z-
dc.date.issued2003en_HK
dc.identifier.citationElectrophoresis, 2003, v. 24 n. 7-8, p. 1311-1318en_HK
dc.identifier.issn0173-0835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67570-
dc.description.abstractUsing two-dimensional gel electrophoresis, we investigated the profile of prostatic secretory proteins in human expressed prostatic secretion (EPS) from benign prostate hyperplasia (BPH) patients and compared the patterns with normal controls. We identified three specifically expressed proteins, including prostate secretory protein 61 (PSP61), in EPS from benign BPH patients but absent in normal controls. In addition, we found that PSP61 was a modified isoform of the well-documented PSP-94, which had a perfect matching (100% homology) to the first 61 amino acids of the PSP-94 protein but with a deleted C-terminus. This shortened PSP61 was not due to alternative splicing of the PSP-94 gene at transcription level. Our results provide first evidence on the possibility of using PSP61 as a specific biological marker for diagnosis of BPH.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA.en_HK
dc.relation.ispartofElectrophoresisen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAlternative Splicingen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshElectrophoresis, Gel, Two-Dimensionalen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Proteins - genetics - isolation & purification - secretionen_HK
dc.subject.meshProstatic Hyperplasia - metabolismen_HK
dc.subject.meshProstatic Secretory Proteins - genetics - isolation & purification - secretionen_HK
dc.subject.meshProtein Isoformsen_HK
dc.subject.meshProtein Processing, Post-Translationalen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.titleIdentification of a specifically expressed modified form of novel PSP-94 protein in the secretion of benign prostatic hyperplasiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0173-0835&volume=24&spage=1311&epage=1318&date=2003&atitle=Identification+of+a+specifically+expressed+modified+form+of+novel+PSP-94+protein+in+the+secretion+of+benign+prostatic+hyperplasiaen_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12707925-
dc.identifier.scopuseid_2-s2.0-0347134732en_HK
dc.identifier.hkuros76296en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347134732&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue7-8en_HK
dc.identifier.spage1311en_HK
dc.identifier.epage1318en_HK
dc.identifier.isiWOS:000182693400022-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridXu, K=7403282051en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK
dc.identifier.scopusauthoridLee, DTW=37047042200en_HK
dc.identifier.scopusauthoridFan, T=7202528808en_HK
dc.identifier.scopusauthoridChan, FL=7202586505en_HK
dc.identifier.scopusauthoridXuan, JJW=7004718080en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK

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