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Article: Expression of E-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies

TitleExpression of E-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies
Authors
Keywordsβ-catenin
E-cadherin
Normal and pathological pregnancies
Trophoblastic tissue
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com
Citation
International Journal Of Gynecological Pathology, 2003, v. 22 n. 1, p. 63-70 How to Cite?
AbstractE-cadherin and β-catenin are cell-cell adhesion molecules, which are thought to play an important role in trophoblastic differentiation and remodelling during gestation. Their expression may be altered in pathological conditions with trophoblastic invasion. In this study, we used immunohistochemical methods to study the pattern of expression of E-cadherin and β-catenin in villous trophoblastic tissue in normal and pathological pregnancies. In villous trophoblastic tissue, E-cadherin had a membranous distribution, whereas β-catenin had a mixed-membranous and granular cytoplasmic distribution. The levels of expression of E-cadherin and β-catenin correlated with each other. From first to third trimesters, the expression of both E-cadherin and β-catenin showed a decreasing trend. In preeclampsia, there was an up-regulation of E-cadherin and β-catenin expression. In placenta accreta, the level of expression of both did not differ from that in normal third-trimester placenta. In gestational trophoblastic diseases, there was a general trend of down-regulation of both E-cadherin and β-catenin. Altered expression of E-cadherin and β-catenin may play a role in the development of normal and pathological placentas.
Persistent Identifierhttp://hdl.handle.net/10722/67562
ISSN
2015 Impact Factor: 1.437
2015 SCImago Journal Rankings: 0.723
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, HWen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorCheung, ALMen_HK
dc.contributor.authorO, WSen_HK
dc.date.accessioned2010-09-06T05:56:14Z-
dc.date.available2010-09-06T05:56:14Z-
dc.date.issued2003en_HK
dc.identifier.citationInternational Journal Of Gynecological Pathology, 2003, v. 22 n. 1, p. 63-70en_HK
dc.identifier.issn0277-1691en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67562-
dc.description.abstractE-cadherin and β-catenin are cell-cell adhesion molecules, which are thought to play an important role in trophoblastic differentiation and remodelling during gestation. Their expression may be altered in pathological conditions with trophoblastic invasion. In this study, we used immunohistochemical methods to study the pattern of expression of E-cadherin and β-catenin in villous trophoblastic tissue in normal and pathological pregnancies. In villous trophoblastic tissue, E-cadherin had a membranous distribution, whereas β-catenin had a mixed-membranous and granular cytoplasmic distribution. The levels of expression of E-cadherin and β-catenin correlated with each other. From first to third trimesters, the expression of both E-cadherin and β-catenin showed a decreasing trend. In preeclampsia, there was an up-regulation of E-cadherin and β-catenin expression. In placenta accreta, the level of expression of both did not differ from that in normal third-trimester placenta. In gestational trophoblastic diseases, there was a general trend of down-regulation of both E-cadherin and β-catenin. Altered expression of E-cadherin and β-catenin may play a role in the development of normal and pathological placentas.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.comen_HK
dc.relation.ispartofInternational Journal of Gynecological Pathologyen_HK
dc.rightsInternational Journal of Gynecological Pathology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectβ-cateninen_HK
dc.subjectE-cadherinen_HK
dc.subjectNormal and pathological pregnanciesen_HK
dc.subjectTrophoblastic tissueen_HK
dc.subject.meshCadherins - biosynthesisen_HK
dc.subject.meshCytoskeletal Proteins - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshPlacenta Accreta - metabolism - pathologyen_HK
dc.subject.meshPre-Eclampsia - metabolism - pathologyen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshTrans-Activators - biosynthesisen_HK
dc.subject.meshTrophoblastic Neoplasms - metabolism - pathologyen_HK
dc.subject.meshTrophoblasts - metabolism - pathologyen_HK
dc.subject.meshUterine Neoplasms - metabolism - pathologyen_HK
dc.subject.meshbeta Cateninen_HK
dc.titleExpression of E-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnanciesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0277-1691&volume=22&spage=63&epage=70&date=2003&atitle=Expression+of+E-cadherin+and+beta-catenin+in+trophoblastic+tissue+in+normal+and+pathological+pregnanciesen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailCheung, ALM:lmcheung@hkucc.hku.hken_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityCheung, ALM=rp00332en_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00004347-200301000-00013en_HK
dc.identifier.pmid12496700en_HK
dc.identifier.scopuseid_2-s2.0-0037214056en_HK
dc.identifier.hkuros75839en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037214056&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue1en_HK
dc.identifier.spage63en_HK
dc.identifier.epage70en_HK
dc.identifier.isiWOS:000180024800013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, HW=37085839000en_HK
dc.identifier.scopusauthoridCheung, ANY=7401806538en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridCheung, ALM=7401806497en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK

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