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Article: The effect of damage of the brachium of the superior colliculus in neonatal and adult hamsters and the use of peripheral nerve to restore retinocollicular projections

TitleThe effect of damage of the brachium of the superior colliculus in neonatal and adult hamsters and the use of peripheral nerve to restore retinocollicular projections
Authors
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at Http://www.sciencedirect.com
Citation
Progress In Brain Research, 1996, v. 112, p. 363-372 How to Cite?
AbstractUsing horseradish peroxidase (HRP) tracing technique, we were able to confirm the critical age in hamsters as reported previously (So et al., 1981). Thus, following transection of the retinal fibers at the brachium of the superior colliculus (BSC) on postnatal-day 4 (P4) or later, no retinocollicular projections were observed in the adult stage. However, the retinal fibers were observed to reinnervate the superior colliculus (SC) if the BSC was cut on P3 or earlier. Physiological recording showed a close to normal retinocollicular map following a BSC damage on P0. Although retinal fibers did not reinnervate the SC following a BSC cut on or after P4, they could be observed to grow along a membrane over the damaged site. Bridging the site of BSC damage in adult hamsters using a segment of peripheral nerve (PN), retinal fibers labelled with WGA-HRP were observed to reinnervate the SC along the PN graft and visual evoked responses could be recorded in the SC showing the PN graft is effective in restoring damaged central visual pathways in adult mammals.
Persistent Identifierhttp://hdl.handle.net/10722/67555
ISSN
2015 Impact Factor: 1.655
2015 SCImago Journal Rankings: 1.637
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_HK
dc.contributor.authorSawai, Hen_HK
dc.contributor.authorIreland, Sen_HK
dc.contributor.authorTay, Den_HK
dc.contributor.authorFukuda, Yen_HK
dc.date.accessioned2010-09-06T05:56:10Z-
dc.date.available2010-09-06T05:56:10Z-
dc.date.issued1996en_HK
dc.identifier.citationProgress In Brain Research, 1996, v. 112, p. 363-372en_HK
dc.identifier.issn0079-6123en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67555-
dc.description.abstractUsing horseradish peroxidase (HRP) tracing technique, we were able to confirm the critical age in hamsters as reported previously (So et al., 1981). Thus, following transection of the retinal fibers at the brachium of the superior colliculus (BSC) on postnatal-day 4 (P4) or later, no retinocollicular projections were observed in the adult stage. However, the retinal fibers were observed to reinnervate the superior colliculus (SC) if the BSC was cut on P3 or earlier. Physiological recording showed a close to normal retinocollicular map following a BSC damage on P0. Although retinal fibers did not reinnervate the SC following a BSC cut on or after P4, they could be observed to grow along a membrane over the damaged site. Bridging the site of BSC damage in adult hamsters using a segment of peripheral nerve (PN), retinal fibers labelled with WGA-HRP were observed to reinnervate the SC along the PN graft and visual evoked responses could be recorded in the SC showing the PN graft is effective in restoring damaged central visual pathways in adult mammals.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at Http://www.sciencedirect.comen_HK
dc.relation.ispartofProgress in Brain Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNeural Pathways - physiologyen_HK
dc.subject.meshPeripheral Nerves - transplantationen_HK
dc.subject.meshRetina - physiologyen_HK
dc.subject.meshSuperior Colliculi - growth & development - injuries - physiologyen_HK
dc.titleThe effect of damage of the brachium of the superior colliculus in neonatal and adult hamsters and the use of peripheral nerve to restore retinocollicular projectionsen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityTay, D=rp00336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8979842-
dc.identifier.scopuseid_2-s2.0-0029830849en_HK
dc.identifier.hkuros21303en_HK
dc.identifier.volume112en_HK
dc.identifier.spage363en_HK
dc.identifier.epage372en_HK
dc.identifier.isiWOS:A1996BJ08P00026-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridSawai, H=7102263837en_HK
dc.identifier.scopusauthoridIreland, S=16939277800en_HK
dc.identifier.scopusauthoridTay, D=7006796825en_HK
dc.identifier.scopusauthoridFukuda, Y=7402720796en_HK

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