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Article: Prostate development and carcinogenesis

TitleProstate development and carcinogenesis
Authors
Issue Date2003
PublisherAcademic Press.
Citation
International Review Of Cytology, 2003, v. 227, p. 65-130 How to Cite?
AbstractThe process involved in the development and carcinogenesis of the prostate gland is complex. During early prostate development, the androgenic hormone from embryonic testicles is required for ductal formation, growth, and branching morphogenesis of the prostate gland. From this early stage, interactions between the epithelium and mesenchyme become firmly established through paracrine influence (i.e., growth factors) from mesenchyme (stroma), in response to testosterone, acting on epithelium to stimulate its proliferation, morphogenetic differentiation, and function. In return, the epithelium also exerts its paracrine effects on mesenchyme by regulating the differentiation and specific organizational pattern of its stromal smooth muscle. In a normal adult prostate, the maintenance of normal glandular structure and function is dependent not only on the constant presence of testosterone, but also on a normal intact and stable stroma. This chapter will concentrate first on factors involved in the normal development of the prostate gland and then on the aberrant changes in the homeostatic balance arising either from within (i.e., mutations) or outside (i.e., changes in hormonal balance) that result in derangements of the prostate gland. Finally, environmental and genetic factors that lead to prostate carcinogenesis including activation of oncogenes and mutations of tumor suppressor genes are also discussed. © 2003 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67554
ISSN
2012 Impact Factor: -999.999
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, XHen_HK
dc.contributor.authorLing, MTen_HK
dc.date.accessioned2010-09-06T05:56:10Z-
dc.date.available2010-09-06T05:56:10Z-
dc.date.issued2003en_HK
dc.identifier.citationInternational Review Of Cytology, 2003, v. 227, p. 65-130en_HK
dc.identifier.issn0074-7696en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67554-
dc.description.abstractThe process involved in the development and carcinogenesis of the prostate gland is complex. During early prostate development, the androgenic hormone from embryonic testicles is required for ductal formation, growth, and branching morphogenesis of the prostate gland. From this early stage, interactions between the epithelium and mesenchyme become firmly established through paracrine influence (i.e., growth factors) from mesenchyme (stroma), in response to testosterone, acting on epithelium to stimulate its proliferation, morphogenetic differentiation, and function. In return, the epithelium also exerts its paracrine effects on mesenchyme by regulating the differentiation and specific organizational pattern of its stromal smooth muscle. In a normal adult prostate, the maintenance of normal glandular structure and function is dependent not only on the constant presence of testosterone, but also on a normal intact and stable stroma. This chapter will concentrate first on factors involved in the normal development of the prostate gland and then on the aberrant changes in the homeostatic balance arising either from within (i.e., mutations) or outside (i.e., changes in hormonal balance) that result in derangements of the prostate gland. Finally, environmental and genetic factors that lead to prostate carcinogenesis including activation of oncogenes and mutations of tumor suppressor genes are also discussed. © 2003 Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherAcademic Press.en_HK
dc.relation.ispartofInternational Review of Cytologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Transformation, Neoplastic - genetics - metabolismen_HK
dc.subject.meshEpithelial Cells - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesoderm - cytology - physiologyen_HK
dc.subject.meshParacrine Communicationen_HK
dc.subject.meshProstate - embryology - growth & developmenten_HK
dc.subject.meshProstatic Neoplasms - pathology - physiopathologyen_HK
dc.titleProstate development and carcinogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0074-7696&volume=227&spage=65&epage=130&date=2003&atitle=Prostate+development+and+carcinogenesisen_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0074-7696(03)01008-8en_HK
dc.identifier.pmid14518550-
dc.identifier.scopuseid_2-s2.0-0141818099en_HK
dc.identifier.hkuros85121en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141818099&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume227en_HK
dc.identifier.spage65en_HK
dc.identifier.epage130en_HK
dc.identifier.isiWOS:000185673500002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, XH=7501854829en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK

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