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Conference Paper: The significance of LMP1 expression in nasopharyngeal carcinoma

TitleThe significance of LMP1 expression in nasopharyngeal carcinoma
Authors
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
Citation
Seminars In Cancer Biology, 2002, v. 12 n. 6, p. 473-487 How to Cite?
Abstract
The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent fibroblasts, and induces a wide range of effects in B cells and epithelial cells. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) engaging a multitude of signaling pathways that include NF-κB, the mitogen-activated protein kinases (MAPKs), JNK, p38, the JAK/STAT pathway and, more recently, the small Rho GTPases. The constitutive activation of these signaling cascades explains LMP1's ability to induce such a diverse array of morphological and phenotypic effects in cells and provides an insight into how LMP1 may induce cell transformation. The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67548
ISSN
2013 Impact Factor: 9.143
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorTramoutanis, Gen_HK
dc.contributor.authorDawson, CWen_HK
dc.contributor.authorLo, AKFen_HK
dc.contributor.authorHuang, DPen_HK
dc.date.accessioned2010-09-06T05:56:07Z-
dc.date.available2010-09-06T05:56:07Z-
dc.date.issued2002en_HK
dc.identifier.citationSeminars In Cancer Biology, 2002, v. 12 n. 6, p. 473-487en_HK
dc.identifier.issn1044-579Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67548-
dc.description.abstractThe Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent fibroblasts, and induces a wide range of effects in B cells and epithelial cells. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) engaging a multitude of signaling pathways that include NF-κB, the mitogen-activated protein kinases (MAPKs), JNK, p38, the JAK/STAT pathway and, more recently, the small Rho GTPases. The constitutive activation of these signaling cascades explains LMP1's ability to induce such a diverse array of morphological and phenotypic effects in cells and provides an insight into how LMP1 may induce cell transformation. The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis. © 2002 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcanceren_HK
dc.relation.ispartofSeminars in Cancer Biologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshCell Transformation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMitogen-Activated Protein Kinases - physiologyen_HK
dc.subject.meshNF-kappa B - metabolismen_HK
dc.subject.meshNasopharyngeal Neoplasms - etiology - virologyen_HK
dc.subject.meshPhosphatidylinositol 3-Kinases - physiologyen_HK
dc.subject.meshViral Matrix Proteins - analysis - chemistry - physiologyen_HK
dc.titleThe significance of LMP1 expression in nasopharyngeal carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1044-579X&volume=12&spage=473&epage=487&date=2002&atitle=The+significance+of+LMP1+expression+in+nasopharyngeal+carcinomaen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1044579X02000901en_HK
dc.identifier.pmid12450733en_HK
dc.identifier.scopuseid_2-s2.0-0036435157en_HK
dc.identifier.hkuros85074en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036435157&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue6en_HK
dc.identifier.spage473en_HK
dc.identifier.epage487en_HK
dc.identifier.isiWOS:000179880800008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridTramoutanis, G=15744714300en_HK
dc.identifier.scopusauthoridDawson, CW=7202226918en_HK
dc.identifier.scopusauthoridLo, AKF=7102780657en_HK
dc.identifier.scopusauthoridHuang, DP=7403891486en_HK

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