Conference Paper: The significance of LMP1 expression in nasopharyngeal carcinoma

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TitleThe significance of LMP1 expression in nasopharyngeal carcinoma
AuthorsTsao, SW1
Tramoutanis, G3
Dawson, CW3
Lo, AKF1
Huang, DP2
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
CitationSeminars In Cancer Biology, 2002, v. 12 n. 6, p. 473-487 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1044579X02000901
AbstractThe Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent fibroblasts, and induces a wide range of effects in B cells and epithelial cells. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) engaging a multitude of signaling pathways that include NF-κB, the mitogen-activated protein kinases (MAPKs), JNK, p38, the JAK/STAT pathway and, more recently, the small Rho GTPases. The constitutive activation of these signaling cascades explains LMP1's ability to induce such a diverse array of morphological and phenotypic effects in cells and provides an insight into how LMP1 may induce cell transformation. The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis. © 2002 Elsevier Science Ltd. All rights reserved.
ISSN1044-579X
2011 Impact Factor: 6.475
2011 SCImago Journal Rankings: 1.288
DOIhttp://dx.doi.org/10.1016/S1044579X02000901
ISI Accession Number IDWOS:000179880800008
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTsao, SW
dc.contributor.authorTramoutanis, G
dc.contributor.authorDawson, CW
dc.contributor.authorLo, AKF
dc.contributor.authorHuang, DP
dc.date.accessioned2010-09-06T05:56:07Z
dc.date.available2010-09-06T05:56:07Z
dc.date.issued2002
dc.description.abstractThe Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent fibroblasts, and induces a wide range of effects in B cells and epithelial cells. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) engaging a multitude of signaling pathways that include NF-κB, the mitogen-activated protein kinases (MAPKs), JNK, p38, the JAK/STAT pathway and, more recently, the small Rho GTPases. The constitutive activation of these signaling cascades explains LMP1's ability to induce such a diverse array of morphological and phenotypic effects in cells and provides an insight into how LMP1 may induce cell transformation. The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis. © 2002 Elsevier Science Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationSeminars In Cancer Biology, 2002, v. 12 n. 6, p. 473-487 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1044579X02000901
dc.identifier.doihttp://dx.doi.org/10.1016/S1044579X02000901
dc.identifier.epage487
dc.identifier.hkuros85074
dc.identifier.isiWOS:000179880800008
dc.identifier.issn1044-579X
2011 Impact Factor: 6.475
2011 SCImago Journal Rankings: 1.288
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmid12450733
dc.identifier.scopuseid_2-s2.0-0036435157
dc.identifier.spage473
dc.identifier.urihttp://hdl.handle.net/10722/67548
dc.identifier.volume12
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
dc.publisher.placeUnited Kingdom
dc.relation.ispartofSeminars in Cancer Biology
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshCell Division
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshHumans
dc.subject.meshMice
dc.subject.meshMitogen-Activated Protein Kinases - physiology
dc.subject.meshNF-kappa B - metabolism
dc.subject.meshNasopharyngeal Neoplasms - etiology - virology
dc.subject.meshPhosphatidylinositol 3-Kinases - physiology
dc.subject.meshViral Matrix Proteins - analysis - chemistry - physiology
dc.titleThe significance of LMP1 expression in nasopharyngeal carcinoma
dc.typeConference_Paper
Author Affiliations
  1. The University of Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. University of Birmingham