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Conference Paper: The significance of LMP1 expression in nasopharyngeal carcinoma
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TitleThe significance of LMP1 expression in nasopharyngeal carcinoma
 
AuthorsTsao, SW1 1
Tramoutanis, G3
Dawson, CW3
Lo, AKF1
Huang, DP2
 
Issue Date2002
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
 
CitationSeminars In Cancer Biology, 2002, v. 12 n. 6, p. 473-487 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1044579X02000901
 
AbstractThe Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent fibroblasts, and induces a wide range of effects in B cells and epithelial cells. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) engaging a multitude of signaling pathways that include NF-κB, the mitogen-activated protein kinases (MAPKs), JNK, p38, the JAK/STAT pathway and, more recently, the small Rho GTPases. The constitutive activation of these signaling cascades explains LMP1's ability to induce such a diverse array of morphological and phenotypic effects in cells and provides an insight into how LMP1 may induce cell transformation. The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis. © 2002 Elsevier Science Ltd. All rights reserved.
 
ISSN1044-579X
2012 Impact Factor: 7.436
2012 SCImago Journal Rankings: 3.389
 
DOIhttp://dx.doi.org/10.1016/S1044579X02000901
 
ISI Accession Number IDWOS:000179880800008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTsao, SW
 
dc.contributor.authorTramoutanis, G
 
dc.contributor.authorDawson, CW
 
dc.contributor.authorLo, AKF
 
dc.contributor.authorHuang, DP
 
dc.date.accessioned2010-09-06T05:56:07Z
 
dc.date.available2010-09-06T05:56:07Z
 
dc.date.issued2002
 
dc.description.abstractThe Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent fibroblasts, and induces a wide range of effects in B cells and epithelial cells. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) engaging a multitude of signaling pathways that include NF-κB, the mitogen-activated protein kinases (MAPKs), JNK, p38, the JAK/STAT pathway and, more recently, the small Rho GTPases. The constitutive activation of these signaling cascades explains LMP1's ability to induce such a diverse array of morphological and phenotypic effects in cells and provides an insight into how LMP1 may induce cell transformation. The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis. © 2002 Elsevier Science Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationSeminars In Cancer Biology, 2002, v. 12 n. 6, p. 473-487 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1044579X02000901
 
dc.identifier.doihttp://dx.doi.org/10.1016/S1044579X02000901
 
dc.identifier.epage487
 
dc.identifier.hkuros85074
 
dc.identifier.isiWOS:000179880800008
 
dc.identifier.issn1044-579X
2012 Impact Factor: 7.436
2012 SCImago Journal Rankings: 3.389
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid12450733
 
dc.identifier.scopuseid_2-s2.0-0036435157
 
dc.identifier.spage473
 
dc.identifier.urihttp://hdl.handle.net/10722/67548
 
dc.identifier.volume12
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofSeminars in Cancer Biology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshCell Division
 
dc.subject.meshCell Transformation, Neoplastic
 
dc.subject.meshHumans
 
dc.subject.meshMice
 
dc.subject.meshMitogen-Activated Protein Kinases - physiology
 
dc.subject.meshNF-kappa B - metabolism
 
dc.subject.meshNasopharyngeal Neoplasms - etiology - virology
 
dc.subject.meshPhosphatidylinositol 3-Kinases - physiology
 
dc.subject.meshViral Matrix Proteins - analysis - chemistry - physiology
 
dc.titleThe significance of LMP1 expression in nasopharyngeal carcinoma
 
dc.typeConference_Paper
 
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<contributor.author>Tramoutanis, G</contributor.author>
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<contributor.author>Huang, DP</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. University of Birmingham