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Article: Macrophage migration inhibitory factor expression in male and female ethanol-fed rats

TitleMacrophage migration inhibitory factor expression in male and female ethanol-fed rats
Authors
Nanji, AALau, GKKTipoe, GLSui, TYChen, YXThomas, PLan, HY
Issue Date2001
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/jir
Citation
Journal Of Interferon And Cytokine Research, 2001, v. 21 n. 12, p. 1055-1062 How to Cite?
DOI: http://dx.doi.org/10.1089/107999001317205187
AbstractMacrophage migration inhibitory factory (MIF) regulates macrophage accumulation at sites of injury and can promote the inflammatory response. We studied MIF expression in the intragastric feeding rat model for alcoholic liver injury. Male and age-matched female rats were fed ethanol or dextrose with fish oil. Two groups of male rats were fed medium-chain triglycerides with ethanol or dextrose. Analysis of liver histopathology, lipid peroxidation, endotoxin, mRNA, and immunohistochemistry for MIF, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were carried out. Male and female rats fed fish oil and ethanol showed necroinflammatory liver injury and had the highest expression of MIF, TNF-α, and IFN-γ in the liver. Decreased levels of MIF protein were seen in rats with higher endotoxin levels, suggesting that preformed MIF is released into the circulation. MIF is an important mediator of the inflammatory response in alcoholic liver disease and a potential therapeutic target.
Persistent Identifierhttp://hdl.handle.net/10722/67517
ISSN
1079-9907
2023 Impact Factor: 1.9
2023 SCImago Journal Rankings: 0.600
ISI Accession Number ID
WOS:000173246300007
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorNanji, AAen_HK
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorSui, TYen_HK
dc.contributor.authorChen, YXen_HK
dc.contributor.authorThomas, Pen_HK
dc.contributor.authorLan, HYen_HK
dc.date.accessioned2010-09-06T05:55:50Z-
dc.date.available2010-09-06T05:55:50Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Interferon And Cytokine Research, 2001, v. 21 n. 12, p. 1055-1062en_HK
dc.identifier.issn1079-9907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67517-
dc.description.abstractMacrophage migration inhibitory factory (MIF) regulates macrophage accumulation at sites of injury and can promote the inflammatory response. We studied MIF expression in the intragastric feeding rat model for alcoholic liver injury. Male and age-matched female rats were fed ethanol or dextrose with fish oil. Two groups of male rats were fed medium-chain triglycerides with ethanol or dextrose. Analysis of liver histopathology, lipid peroxidation, endotoxin, mRNA, and immunohistochemistry for MIF, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were carried out. Male and female rats fed fish oil and ethanol showed necroinflammatory liver injury and had the highest expression of MIF, TNF-α, and IFN-γ in the liver. Decreased levels of MIF protein were seen in rats with higher endotoxin levels, suggesting that preformed MIF is released into the circulation. MIF is an important mediator of the inflammatory response in alcoholic liver disease and a potential therapeutic target.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/jiren_HK
dc.relation.ispartofJournal of Interferon and Cytokine Researchen_HK
dc.rightsThis is a copy of an article published in the [Journal of Interferon & Cytokine Research] © [2001] [copyright Mary Ann Liebert, Inc.]; [Journal of Interferon & Cytokine Research} is available online at: http://www.liebertonline.com.-
dc.subject.meshAdministration, Oralen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshEndotoxemia - immunologyen_HK
dc.subject.meshEthanol - administration & dosage - pharmacologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis, Alcoholic - genetics - immunology - pathologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshInterferon-gamma - biosynthesis - geneticsen_HK
dc.subject.meshLipid Peroxidationen_HK
dc.subject.meshLiver - immunology - pathologyen_HK
dc.subject.meshMacrophage Migration-Inhibitory Factors - biosynthesis - genetics - immunologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshRNA, Messenger - biosynthesisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Wistaren_HK
dc.subject.meshTranscription, Geneticen_HK
dc.subject.meshTumor Necrosis Factor-alpha - biosynthesisen_HK
dc.titleMacrophage migration inhibitory factor expression in male and female ethanol-fed ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-9907&volume=21&issue=12&spage=1055&epage=1062&date=2001&atitle=Macrophage+migration+inhibitory+factor+expression+in+male+and+female+ethanol-fed+ratsen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/107999001317205187en_HK
dc.identifier.pmid11798463-
dc.identifier.scopuseid_2-s2.0-0035704002en_HK
dc.identifier.hkuros67751en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035704002&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1055en_HK
dc.identifier.epage1062en_HK
dc.identifier.isiWOS:000173246300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNanji, AA=35885060300en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridSui, TY=37093957300en_HK
dc.identifier.scopusauthoridChen, YX=16416830300en_HK
dc.identifier.scopusauthoridThomas, P=16074032300en_HK
dc.identifier.scopusauthoridLan, HY=7102710832en_HK
dc.identifier.issnl1079-9907-

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