File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia

TitleThe effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia
Authors
Issue Date2001
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Journal Of Respiratory And Critical Care Medicine, 2001, v. 163 n. 4, p. 983-988 How to Cite?
AbstractThe increased susceptibility of the elderly to lower respiratory tract infection cannot be fully explained. Although mucociliary clearance, which is affected by ciliary beating and ultrastructure, plays a crucial role in the defense of the airways against inhaled microbes, little is known of the effects of aging on these parameters. We studied the nasal mucociliary clearance (NMCC) time, ciliary beat frequency, and ultrastructure of respiratory cilia in a cohort of healthy volunteers (age range 11 to 90 yr). Ciliary beat frequency of ciliated nasal epithelial cells was obtained via an established photometric method, and NMCC time was measured with the saccharine test. There was a correlation of ciliary beat frequency (r = -0.48, p = 0.0001) and NMCC time r = 0.64, p < 0.001) with increasing age. Transmission electron microscopy revealed an increase in the percent of subjects exhibiting microtubular disarrangement and single central microtubules with aging (p = 0.002 and p = 0.005, respectively). Subjects older than 40 yr of age had significantly slower ciliary beat frequency, higher percent of ciliary cross-sections displaying single tubules, and longer NMCC time than their younger counterparts (p < 0.05). These findings may help explain the frequent occurrence of respiratory infection in the elderly.
Persistent Identifierhttp://hdl.handle.net/10722/67510
ISSN
2015 Impact Factor: 13.118
2015 SCImago Journal Rankings: 5.832
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, JCen_HK
dc.contributor.authorChan, KNen_HK
dc.contributor.authorHu, WHen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorSun, Jen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorTsang, KWen_HK
dc.date.accessioned2010-09-06T05:55:46Z-
dc.date.available2010-09-06T05:55:46Z-
dc.date.issued2001en_HK
dc.identifier.citationAmerican Journal Of Respiratory And Critical Care Medicine, 2001, v. 163 n. 4, p. 983-988en_HK
dc.identifier.issn1073-449Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67510-
dc.description.abstractThe increased susceptibility of the elderly to lower respiratory tract infection cannot be fully explained. Although mucociliary clearance, which is affected by ciliary beating and ultrastructure, plays a crucial role in the defense of the airways against inhaled microbes, little is known of the effects of aging on these parameters. We studied the nasal mucociliary clearance (NMCC) time, ciliary beat frequency, and ultrastructure of respiratory cilia in a cohort of healthy volunteers (age range 11 to 90 yr). Ciliary beat frequency of ciliated nasal epithelial cells was obtained via an established photometric method, and NMCC time was measured with the saccharine test. There was a correlation of ciliary beat frequency (r = -0.48, p = 0.0001) and NMCC time r = 0.64, p < 0.001) with increasing age. Transmission electron microscopy revealed an increase in the percent of subjects exhibiting microtubular disarrangement and single central microtubules with aging (p = 0.002 and p = 0.005, respectively). Subjects older than 40 yr of age had significantly slower ciliary beat frequency, higher percent of ciliary cross-sections displaying single tubules, and longer NMCC time than their younger counterparts (p < 0.05). These findings may help explain the frequent occurrence of respiratory infection in the elderly.en_HK
dc.languageengen_HK
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_HK
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicineen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAging - pathology - physiologyen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshChilden_HK
dc.subject.meshCilia - physiology - ultrastructureen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMucociliary Clearanceen_HK
dc.subject.meshNasal Mucosa - physiology - ultrastructureen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshRespiratory Tract Diseases - etiology - physiopathologyen_HK
dc.titleThe effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory ciliaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1073-449X&volume=163&spage=983&epage=988&date=2001&atitle=The+effect+of+aging+on+nasal+mucociliary+clearance,+beat+frequency,+and+ultrastructure+of+respiratory+ciliaen_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11282777-
dc.identifier.scopuseid_2-s2.0-0035060220en_HK
dc.identifier.hkuros63863en_HK
dc.identifier.hkuros56468-
dc.identifier.hkuros68263-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035060220&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue4en_HK
dc.identifier.spage983en_HK
dc.identifier.epage988en_HK
dc.identifier.isiWOS:000168057700038-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridChan, KN=15737866400en_HK
dc.identifier.scopusauthoridHu, WH=25932937100en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridZheng, L=7403404086en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridSun, J=7410371598en_HK
dc.identifier.scopusauthoridLeung, R=23397126100en_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats