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Article: Development of the regenerative capacity of postnatal axotomized rat spinal motoneurons

TitleDevelopment of the regenerative capacity of postnatal axotomized rat spinal motoneurons
Authors
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2002, v. 13 n. 8, p. 1071-1074 How to Cite?
AbstractThe present study examined whether a peripheral nerve (PN) graft can rescue developing motoneurons from degeneration and determined when immature motoneurons begin to express a regenerative capacity. Transplantation of a PN graft was unable to rescue motoneurons from degeneration if spinal root avulsion was performed in animals younger than P14. However, this procedure did enhance motoneuron survival when root avulsion was performed at P14 or later. Immature (P1 or P7) motoneurons were unable to regenerate their axons into the transplanted PN graft following root avulsion, whereas in older animals (P14-P28) motoneurons were able to regenerate axons into the PN graft. The percentage of regenerated motoneurons increased from P21 to P28 and was similar to that of adult animals. Therefore, the regenerative capacity of rat spinal motoneurons first begins at about P14, which seems to be critical. © 2002 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/67509
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, YMen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorYip, HKen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:55:45Z-
dc.date.available2010-09-06T05:55:45Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroreport, 2002, v. 13 n. 8, p. 1071-1074en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67509-
dc.description.abstractThe present study examined whether a peripheral nerve (PN) graft can rescue developing motoneurons from degeneration and determined when immature motoneurons begin to express a regenerative capacity. Transplantation of a PN graft was unable to rescue motoneurons from degeneration if spinal root avulsion was performed in animals younger than P14. However, this procedure did enhance motoneuron survival when root avulsion was performed at P14 or later. Immature (P1 or P7) motoneurons were unable to regenerate their axons into the transplanted PN graft following root avulsion, whereas in older animals (P14-P28) motoneurons were able to regenerate axons into the PN graft. The percentage of regenerated motoneurons increased from P21 to P28 and was similar to that of adult animals. Therefore, the regenerative capacity of rat spinal motoneurons first begins at about P14, which seems to be critical. © 2002 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroreport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAging - physiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newborn - anatomy & histology - physiologyen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCell Survival - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFluorescent Dyes - diagnostic useen_HK
dc.subject.meshFunctional Laterality - physiologyen_HK
dc.subject.meshGraft Survival - physiologyen_HK
dc.subject.meshGrowth Cones - physiology - ultrastructureen_HK
dc.subject.meshMotor Neurons - cytology - physiologyen_HK
dc.subject.meshNerve Regeneration - physiologyen_HK
dc.subject.meshPeripheral Nerves - cytology - physiology - transplantationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRhizotomyen_HK
dc.subject.meshSpinal Cord - cytology - physiologyen_HK
dc.subject.meshSpinal Cord Injuries - pathology - physiopathologyen_HK
dc.subject.meshStilbamidinesen_HK
dc.subject.meshTissue Transplantationen_HK
dc.titleDevelopment of the regenerative capacity of postnatal axotomized rat spinal motoneuronsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=13 No 8&spage=1071&epage=1074&date=2002&atitle=Development+of+the+regenerative+capacity+of+postnatal+axotomized+rat+spinal+motoneuronsen_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12060811-
dc.identifier.scopuseid_2-s2.0-0037067055en_HK
dc.identifier.hkuros74636en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037067055&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1071en_HK
dc.identifier.epage1074en_HK
dc.identifier.isiWOS:000176823600026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, YM=36989085800en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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