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Article: Growth factors and epithelial-stromal interactions in prostate cancer development

TitleGrowth factors and epithelial-stromal interactions in prostate cancer development
Authors
Issue Date2000
PublisherAcademic Press.
Citation
International Review Of Cytology, 2000, v. 199, p. 65-116 How to Cite?
AbstractEpithelial-stromal interactions are important not only in growth, development, and functional cytodifferentiation of the prostate but also in derangements of prostate gland such as BPH and prostate carcinoma. This chapter explores the roles of epithelium and stroma during this delicate process and highlights the role and mutual influence of each on the other. It also examines the importance of ECM in mediating the effects of androgens and drawn attention to estrogen and genetic factors in the process. During this process of epithelial-stromal interaction, growth factors play a central role in mediating the interactions. This chapter focuses on the role of several growth factors including epidermal growth factor, fibroblast growth factor, transforming growth factor alpha, transforming growth factor beta, insulin-like growth factor-1, vascular endothelial growth factor, nerve growth factor, platelet-derived growth factor, and hepatocyte growth factor. This chapter emphasizes the importance of epithelial-stromal interactions in tumorigenesis and highlights the switch of paracrine to autocrine mode during the process of carcinogenesis. (C) 2000 Academic Press.
Persistent Identifierhttp://hdl.handle.net/10722/67507
ISSN
2012 Impact Factor: -999.999
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, YZen_HK
dc.date.accessioned2010-09-06T05:55:44Z-
dc.date.available2010-09-06T05:55:44Z-
dc.date.issued2000en_HK
dc.identifier.citationInternational Review Of Cytology, 2000, v. 199, p. 65-116en_HK
dc.identifier.issn0074-7696en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67507-
dc.description.abstractEpithelial-stromal interactions are important not only in growth, development, and functional cytodifferentiation of the prostate but also in derangements of prostate gland such as BPH and prostate carcinoma. This chapter explores the roles of epithelium and stroma during this delicate process and highlights the role and mutual influence of each on the other. It also examines the importance of ECM in mediating the effects of androgens and drawn attention to estrogen and genetic factors in the process. During this process of epithelial-stromal interaction, growth factors play a central role in mediating the interactions. This chapter focuses on the role of several growth factors including epidermal growth factor, fibroblast growth factor, transforming growth factor alpha, transforming growth factor beta, insulin-like growth factor-1, vascular endothelial growth factor, nerve growth factor, platelet-derived growth factor, and hepatocyte growth factor. This chapter emphasizes the importance of epithelial-stromal interactions in tumorigenesis and highlights the switch of paracrine to autocrine mode during the process of carcinogenesis. (C) 2000 Academic Press.en_HK
dc.languageengen_HK
dc.publisherAcademic Press.en_HK
dc.relation.ispartofInternational Review of Cytologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshEpithelial Cells - metabolism - ultrastructureen_HK
dc.subject.meshGrowth Substances - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesoderm - metabolism - ultrastructureen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshProstate - growth & development - physiology - ultrastructureen_HK
dc.subject.meshProstatic Neoplasms - metabolism - pathology - ultrastructureen_HK
dc.subject.meshStromal Cells - metabolism - ultrastructureen_HK
dc.titleGrowth factors and epithelial-stromal interactions in prostate cancer developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0074-7696&volume=199&spage=65&epage=116&date=2000&atitle=Growth+factors+and+epithelial-stromal+interactions+in+prostate+cancer+developmenten_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10874577-
dc.identifier.scopuseid_2-s2.0-0033918096en_HK
dc.identifier.hkuros51939en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033918096&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume199en_HK
dc.identifier.spage65en_HK
dc.identifier.epage116en_HK
dc.identifier.isiWOS:000088257600002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, YZ=8581934500en_HK

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