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Article: Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma

TitleModulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
Authors
KeywordsGlaucoma
IGF-1
MCP-1/CCL2
Microglia
Neuroprotection
Issue Date2010
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 How to Cite?
AbstractMonocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67499
ISSN
2014 Impact Factor: 4.112
ISI Accession Number ID
Funding AgencyGrant Number
Glaucoma Foundation, New York, USA
University of Hong Kong
Funding Information:

This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorChiu, Ken_HK
dc.contributor.authorYeung, SCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-06T05:55:40Z-
dc.date.available2010-09-06T05:55:40Z-
dc.date.issued2010en_HK
dc.identifier.citationCellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68en_HK
dc.identifier.issn1672-7681en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67499-
dc.description.abstractMonocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_HK
dc.relation.ispartofCellular and Molecular Immunologyen_HK
dc.subjectGlaucomaen_HK
dc.subjectIGF-1en_HK
dc.subjectMCP-1/CCL2en_HK
dc.subjectMicrogliaen_HK
dc.subjectNeuroprotectionen_HK
dc.subject.meshCell Shape-
dc.subject.meshChemokine CCL2 - immunology-
dc.subject.meshGlaucoma - immunology - pathology-
dc.subject.meshMicroglia - immunology - pathology-
dc.subject.meshInsulin-Like Growth Factor I/immunology-
dc.titleModulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1672-7681&volume=7&issue=1&spage=61&epage=68&date=2010&atitle=Modulation+of+morphological+changes+of+microglia+and+neuroprotection+by+monocyte+chemoattractant+protein-1+in+experimental+glaucomaen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/cmi.2009.110en_HK
dc.identifier.pmid20081877-
dc.identifier.scopuseid_2-s2.0-75949099155en_HK
dc.identifier.hkuros169287en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75949099155&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.identifier.spage61en_HK
dc.identifier.epage68en_HK
dc.identifier.isiWOS:000274323900008-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridChiu, K=15076970500en_HK
dc.identifier.scopusauthoridYeung, SC=25923636600en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK

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