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Article: Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
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TitleModulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
 
AuthorsChiu, K2
Yeung, SC2
So, KF2 1
Chang, RCC2 1
 
KeywordsGlaucoma
IGF-1
MCP-1/CCL2
Microglia
Neuroprotection
 
Issue Date2010
 
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
 
CitationCellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 [How to Cite?]
DOI: http://dx.doi.org/10.1038/cmi.2009.110
 
AbstractMonocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved.
 
ISSN1672-7681
2013 Impact Factor: 4.185
 
DOIhttp://dx.doi.org/10.1038/cmi.2009.110
 
ISI Accession Number IDWOS:000274323900008
Funding AgencyGrant Number
Glaucoma Foundation, New York, USA
University of Hong Kong
Funding Information:

This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChiu, K
 
dc.contributor.authorYeung, SC
 
dc.contributor.authorSo, KF
 
dc.contributor.authorChang, RCC
 
dc.date.accessioned2010-09-06T05:55:40Z
 
dc.date.available2010-09-06T05:55:40Z
 
dc.date.issued2010
 
dc.description.abstractMonocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 [How to Cite?]
DOI: http://dx.doi.org/10.1038/cmi.2009.110
 
dc.identifier.doihttp://dx.doi.org/10.1038/cmi.2009.110
 
dc.identifier.epage68
 
dc.identifier.hkuros169287
 
dc.identifier.isiWOS:000274323900008
Funding AgencyGrant Number
Glaucoma Foundation, New York, USA
University of Hong Kong
Funding Information:

This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong.

 
dc.identifier.issn1672-7681
2013 Impact Factor: 4.185
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid20081877
 
dc.identifier.scopuseid_2-s2.0-75949099155
 
dc.identifier.spage61
 
dc.identifier.urihttp://hdl.handle.net/10722/67499
 
dc.identifier.volume7
 
dc.languageeng
 
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
 
dc.publisher.placeChina
 
dc.relation.ispartofCellular and Molecular Immunology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCell Shape
 
dc.subject.meshChemokine CCL2 - immunology
 
dc.subject.meshGlaucoma - immunology - pathology
 
dc.subject.meshMicroglia - immunology - pathology
 
dc.subject.meshInsulin-Like Growth Factor I/immunology
 
dc.subjectGlaucoma
 
dc.subjectIGF-1
 
dc.subjectMCP-1/CCL2
 
dc.subjectMicroglia
 
dc.subjectNeuroprotection
 
dc.titleModulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong