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Article: Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma

TitleModulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
Authors
KeywordsGlaucoma
IGF-1
MCP-1/CCL2
Microglia
Neuroprotection
Issue Date2010
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 How to Cite?
Abstract
Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67499
ISSN
2013 Impact Factor: 4.185
ISI Accession Number ID
Funding AgencyGrant Number
Glaucoma Foundation, New York, USA
University of Hong Kong
Funding Information:

This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong.

References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChiu, Ken_HK
dc.contributor.authorYeung, SCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-06T05:55:40Z-
dc.date.available2010-09-06T05:55:40Z-
dc.date.issued2010en_HK
dc.identifier.citationCellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68en_HK
dc.identifier.issn1672-7681en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67499-
dc.description.abstractMonocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_HK
dc.relation.ispartofCellular and Molecular Immunologyen_HK
dc.subjectGlaucomaen_HK
dc.subjectIGF-1en_HK
dc.subjectMCP-1/CCL2en_HK
dc.subjectMicrogliaen_HK
dc.subjectNeuroprotectionen_HK
dc.subject.meshCell Shape-
dc.subject.meshChemokine CCL2 - immunology-
dc.subject.meshGlaucoma - immunology - pathology-
dc.subject.meshMicroglia - immunology - pathology-
dc.subject.meshInsulin-Like Growth Factor I/immunology-
dc.titleModulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1672-7681&volume=7&issue=1&spage=61&epage=68&date=2010&atitle=Modulation+of+morphological+changes+of+microglia+and+neuroprotection+by+monocyte+chemoattractant+protein-1+in+experimental+glaucomaen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/cmi.2009.110en_HK
dc.identifier.pmid20081877en_HK
dc.identifier.scopuseid_2-s2.0-75949099155en_HK
dc.identifier.hkuros169287en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75949099155&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.identifier.spage61en_HK
dc.identifier.epage68en_HK
dc.identifier.isiWOS:000274323900008-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridChiu, K=15076970500en_HK
dc.identifier.scopusauthoridYeung, SC=25923636600en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK

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