Article: Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
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- Publisher Website: 10.1038/cmi.2009.110
- Scopus: eid_2-s2.0-75949099155
- PMID: 20081877
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| Title | Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Chiu, K2 Yeung, SC2 So, KF1 2 Chang, RCC1 2 | ||||||
| Keywords | Glaucoma IGF-1 MCP-1/CCL2 Microglia Neuroprotection | ||||||
| Issue Date | 2010 | ||||||
| Publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html | ||||||
| Citation | Cellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 [How to Cite?] DOI: http://dx.doi.org/10.1038/cmi.2009.110 | ||||||
| Abstract | Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved. | ||||||
| ISSN | 1672-7681 2011 Impact Factor: 2.992 2011 SCImago Journal Rankings: 0.341 | ||||||
| DOI | http://dx.doi.org/10.1038/cmi.2009.110 | ||||||
| ISI Accession Number ID | WOS:000274323900008
Funding Information: This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong. | ||||||
| References | References in Scopus |
| dc.contributor.author | Chiu, K | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Yeung, SC | ||||||
| dc.contributor.author | So, KF | ||||||
| dc.contributor.author | Chang, RCC | ||||||
| dc.date.accessioned | 2010-09-06T05:55:40Z | ||||||
| dc.date.available | 2010-09-06T05:55:40Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Cellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 [How to Cite?] DOI: http://dx.doi.org/10.1038/cmi.2009.110 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/cmi.2009.110 | ||||||
| dc.identifier.epage | 68 | ||||||
| dc.identifier.hkuros | 169287 | ||||||
| dc.identifier.isi | WOS:000274323900008
Funding Information: This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong. | ||||||
| dc.identifier.issn | 1672-7681 2011 Impact Factor: 2.992 2011 SCImago Journal Rankings: 0.341 | ||||||
| dc.identifier.issue | 1 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 20081877 | ||||||
| dc.identifier.scopus | eid_2-s2.0-75949099155 | ||||||
| dc.identifier.spage | 61 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/67499 | ||||||
| dc.identifier.volume | 7 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html | ||||||
| dc.publisher.place | China | ||||||
| dc.relation.ispartof | Cellular and Molecular Immunology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Cell Shape | ||||||
| dc.subject.mesh | Chemokine CCL2 - immunology | ||||||
| dc.subject.mesh | Glaucoma - immunology - pathology | ||||||
| dc.subject.mesh | Microglia - immunology - pathology | ||||||
| dc.subject.mesh | Insulin-Like Growth Factor I/immunology | ||||||
| dc.subject | Glaucoma | ||||||
| dc.subject | IGF-1 | ||||||
| dc.subject | MCP-1/CCL2 | ||||||
| dc.subject | Microglia | ||||||
| dc.subject | Neuroprotection | ||||||
| dc.title | Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- The University of Hong Kong