File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat

TitleChanges in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat
Authors
Issue Date2000
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBI
Citation
Tumor Biology, 2000, v. 21 n. 6, p. 328-336 How to Cite?
AbstractWe investigated the changes in serum and tissue zinc levels in the Noble rat prostate gland under different pathological conditions induced by the administration of a combination of testosterone and 17β-estradiol. The results showed that there were significant differences in serum zinc values between normal and hormone-treated rats with prostatic hyperplasia, dysplasia and prostatic carcinoma (p < 0.05), although there was no significant difference among rats with different forms of prostatic lesions (i.e. hyperplasia, dysplasia and prostatic adenocarcinoma). There was also a difference in zinc content between the lateral prostate (LP), ventral prostate (VP) and dorsal prostate (DP) in normal rats. The zinc levels of LP were several times greater than those of either VP or DP (p < 0.01). There was also a great difference in zinc levels between the normal and the hyperplastic/dysplastic and carcinomatous LP and VP (p < 0.05). The levels of zinc in both LP and VP were increased in hyperplasia/dysplasia and carcinoma. On the other hand, the zinc levels of LP were much higher than those of VP in hyperplasia/dysplasia and carcinoma (p < 0.01), which may be correlated with the incidence of prostate cancers in these lobes (i.e. higher in LP and much lower in VP). In contrast, in DP, the levels of zinc were not affected, which may be correlated with the very low incidence of carcinoma in this lobe. Our data suggest that the difference in zinc levels among these lobes reflect the heterogeneity in zinc content in various lobes of the rat prostate. The growth and development of prostatic lesions in LP and VP may be positively correlated with the significant increase in tissue zinc levels in these lobes. On the other hand, the lack of response of DP to carcinogenesis may be due to its relatively stable low zinc levels. It is suggested that tissue zinc content may be used as a marker for prostatic lesions, including hyperplasia, dysplasia and carcinoma, while serum zinc levels may be a useful indicator for abnormal prostatic growth. Copyright (C) 2000 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/67496
ISSN
2015 Impact Factor: 2.926
2015 SCImago Journal Rankings: 0.989
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, YZen_HK
dc.contributor.authorLee, JSKen_HK
dc.contributor.authorTam, NNCen_HK
dc.contributor.authorLee, Den_HK
dc.date.accessioned2010-09-06T05:55:39Z-
dc.date.available2010-09-06T05:55:39Z-
dc.date.issued2000en_HK
dc.identifier.citationTumor Biology, 2000, v. 21 n. 6, p. 328-336en_HK
dc.identifier.issn1010-4283en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67496-
dc.description.abstractWe investigated the changes in serum and tissue zinc levels in the Noble rat prostate gland under different pathological conditions induced by the administration of a combination of testosterone and 17β-estradiol. The results showed that there were significant differences in serum zinc values between normal and hormone-treated rats with prostatic hyperplasia, dysplasia and prostatic carcinoma (p < 0.05), although there was no significant difference among rats with different forms of prostatic lesions (i.e. hyperplasia, dysplasia and prostatic adenocarcinoma). There was also a difference in zinc content between the lateral prostate (LP), ventral prostate (VP) and dorsal prostate (DP) in normal rats. The zinc levels of LP were several times greater than those of either VP or DP (p < 0.01). There was also a great difference in zinc levels between the normal and the hyperplastic/dysplastic and carcinomatous LP and VP (p < 0.05). The levels of zinc in both LP and VP were increased in hyperplasia/dysplasia and carcinoma. On the other hand, the zinc levels of LP were much higher than those of VP in hyperplasia/dysplasia and carcinoma (p < 0.01), which may be correlated with the incidence of prostate cancers in these lobes (i.e. higher in LP and much lower in VP). In contrast, in DP, the levels of zinc were not affected, which may be correlated with the very low incidence of carcinoma in this lobe. Our data suggest that the difference in zinc levels among these lobes reflect the heterogeneity in zinc content in various lobes of the rat prostate. The growth and development of prostatic lesions in LP and VP may be positively correlated with the significant increase in tissue zinc levels in these lobes. On the other hand, the lack of response of DP to carcinogenesis may be due to its relatively stable low zinc levels. It is suggested that tissue zinc content may be used as a marker for prostatic lesions, including hyperplasia, dysplasia and carcinoma, while serum zinc levels may be a useful indicator for abnormal prostatic growth. Copyright (C) 2000 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBIen_HK
dc.relation.ispartofTumor Biologyen_HK
dc.subject.meshAdenocarcinoma - blood - chemically induced - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshEstradiol - analogs & derivatives - toxicityen_HK
dc.subject.meshGonadal Steroid Hormones - toxicityen_HK
dc.subject.meshMaleen_HK
dc.subject.meshProstate - drug effects - metabolismen_HK
dc.subject.meshProstatic Neoplasms - blood - chemically induced - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshTestosterone - toxicityen_HK
dc.subject.meshZinc - blood - metabolismen_HK
dc.titleChanges in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-4283&volume=21&spage=328&epage=336&date=2000&atitle=Changes+in+serum+and+tissue+zinc+levels+in+sex+hormone-induced+prostatic+carcinogenesis+in+the+noble+raten_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11006573-
dc.identifier.scopuseid_2-s2.0-0033803756en_HK
dc.identifier.hkuros56138en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033803756&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue6en_HK
dc.identifier.spage328en_HK
dc.identifier.epage336en_HK
dc.identifier.isiWOS:000089773500002-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, YZ=8581934500en_HK
dc.identifier.scopusauthoridLee, JSK=16492103000en_HK
dc.identifier.scopusauthoridTam, NNC=7101712624en_HK
dc.identifier.scopusauthoridLee, D=7406666118en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats