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Article: Prognostic significance of Id-1 and its association with EGFR in renal cell cancer

TitlePrognostic significance of Id-1 and its association with EGFR in renal cell cancer
Authors
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 2007, v. 50 n. 4, p. 484-490 How to Cite?
AbstractAims: Epidermal growth factor receptor (EGFR) is suggested as one of the positive regulators in the invasive progression of renal cell cancer (RCC). Recently, Id-1 (inhibitor of differentiation or DNA binding), a helix-loop-helix transcription factor, has been identified as one of the key factors in the EGFR signalling pathway. The aim of this study was to investigate the significance of Id-1 expression in renal cell cancer and to study its relationship with EGFR. Methods and results: Id-1 and EGFR expression was examined in tissue microarray (TMA) samples of 107 RCC and 32 normal kidney specimens by immunohistochemistry. Relative Id-1 and EGFR protein expression was quantified by estimating the staining intensity on a four-grade scale. We found that while negative to weak expression of Id-1 and EGFR was observed in non-malignant kidney tissues, most RCCs showed significant positive Id-1 and EGFR expression in tumour cells. In addition, Id-1 immunostaining intensity was positively associated with increased tumour staging, grading and EGFR expression. Conclusion: Overexpression of Id-1 is a novel marker for advanced RCC which is positively correlated with EGFR expression. Our results suggest that Id-1 may play an important role in the development of RCC and indicate that Id-1 is a potential marker of patients with a poor prognosis. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/67483
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.contributor.authorZhangen_HK
dc.contributor.authorXin, Den_HK
dc.contributor.authorChua, CWen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorLeung, SCLen_HK
dc.contributor.authorNa, Yen_HK
dc.contributor.authorWang, Xen_HK
dc.date.accessioned2010-09-06T05:55:32Z-
dc.date.available2010-09-06T05:55:32Z-
dc.date.issued2007en_HK
dc.identifier.citationHistopathology, 2007, v. 50 n. 4, p. 484-490en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67483-
dc.description.abstractAims: Epidermal growth factor receptor (EGFR) is suggested as one of the positive regulators in the invasive progression of renal cell cancer (RCC). Recently, Id-1 (inhibitor of differentiation or DNA binding), a helix-loop-helix transcription factor, has been identified as one of the key factors in the EGFR signalling pathway. The aim of this study was to investigate the significance of Id-1 expression in renal cell cancer and to study its relationship with EGFR. Methods and results: Id-1 and EGFR expression was examined in tissue microarray (TMA) samples of 107 RCC and 32 normal kidney specimens by immunohistochemistry. Relative Id-1 and EGFR protein expression was quantified by estimating the staining intensity on a four-grade scale. We found that while negative to weak expression of Id-1 and EGFR was observed in non-malignant kidney tissues, most RCCs showed significant positive Id-1 and EGFR expression in tumour cells. In addition, Id-1 immunostaining intensity was positively associated with increased tumour staging, grading and EGFR expression. Conclusion: Overexpression of Id-1 is a novel marker for advanced RCC which is positively correlated with EGFR expression. Our results suggest that Id-1 may play an important role in the development of RCC and indicate that Id-1 is a potential marker of patients with a poor prognosis. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Renal Cell - metabolism - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshInhibitor of Differentiation Protein 1 - biosynthesisen_HK
dc.subject.meshKidney - metabolism - pathologyen_HK
dc.subject.meshKidney Neoplasms - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Invasivenessen_HK
dc.subject.meshReceptor, Epidermal Growth Factor - physiologyen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.titlePrognostic significance of Id-1 and its association with EGFR in renal cell canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=50&spage=484&epage=490&date=2007&atitle=Prognostic+significance+of+Id-1+and+its+association+with+EGFR+in+renal+cell+canceren_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2559.2007.02637.xen_HK
dc.identifier.pmid17448024-
dc.identifier.scopuseid_2-s2.0-33847289707en_HK
dc.identifier.hkuros147309en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847289707&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue4en_HK
dc.identifier.spage484en_HK
dc.identifier.epage490en_HK
dc.identifier.isiWOS:000244518600010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, X=36072733900en_HK
dc.identifier.scopusauthoridZhang=16023302600en_HK
dc.identifier.scopusauthoridXin, D=7006327751en_HK
dc.identifier.scopusauthoridChua, CW=9437494600en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridLeung, SCL=36894169100en_HK
dc.identifier.scopusauthoridNa, Y=7006088519en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.citeulike1136781-

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