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Article: A voluntary oral-feeding rat model for pathological alcoholic liver injury

TitleA voluntary oral-feeding rat model for pathological alcoholic liver injury
Authors
Issue Date2008
PublisherHumana Press, Inc.
Citation
Methods In Molecular Biology, 2008, v. 447, p. 11-31 How to Cite?
AbstractThe variety of animal models used in the study of alcoholic liver disease reflects the formidable task of developing a model that replicates the human disease. We show that oral feeding of fatty acids derived from fish oil and ethanol induces fatty liver, necrosis, inflammation, and fibrosis. Together with the study of oxidative and nitrosative stress markers, cytokines, proteasome function, and protein studies, this model has provided an inexpensive and technically simple method of establishing pathological alcoholic liver injury. © 2008 Humana Press, a part of Springer Science + Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/67475
ISSN
2015 SCImago Journal Rankings: 0.549
References

 

DC FieldValueLanguage
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorLiong, ECen_HK
dc.contributor.authorLeung, TMen_HK
dc.contributor.authorNanji, AAen_HK
dc.date.accessioned2010-09-06T05:55:28Z-
dc.date.available2010-09-06T05:55:28Z-
dc.date.issued2008en_HK
dc.identifier.citationMethods In Molecular Biology, 2008, v. 447, p. 11-31en_HK
dc.identifier.issn1064-3745en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67475-
dc.description.abstractThe variety of animal models used in the study of alcoholic liver disease reflects the formidable task of developing a model that replicates the human disease. We show that oral feeding of fatty acids derived from fish oil and ethanol induces fatty liver, necrosis, inflammation, and fibrosis. Together with the study of oxidative and nitrosative stress markers, cytokines, proteasome function, and protein studies, this model has provided an inexpensive and technically simple method of establishing pathological alcoholic liver injury. © 2008 Humana Press, a part of Springer Science + Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherHumana Press, Inc.en_HK
dc.relation.ispartofMethods in Molecular Biologyen_HK
dc.subject.meshAdministration, Oralen_HK
dc.subject.meshAlanine Transaminase - blooden_HK
dc.subject.meshAlcohol Drinking - genetics - metabolism - pathologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCentral Nervous System Depressants - administration & dosage - metabolismen_HK
dc.subject.meshChymotrypsin - metabolismen_HK
dc.subject.meshCytochrome P-450 CYP2E1 - metabolismen_HK
dc.subject.meshDinoprost - analogs & derivatives - blooden_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshElectrophoretic Mobility Shift Assayen_HK
dc.subject.meshEndotoxins - blooden_HK
dc.subject.meshEthanol - administration & dosage - metabolismen_HK
dc.subject.meshFatty Acids - administration & dosageen_HK
dc.subject.meshFatty Liver, Alcoholic - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLiver - enzymology - pathologyen_HK
dc.subject.meshLiver Diseases, Alcoholic - genetics - metabolism - pathologyen_HK
dc.subject.meshOxidative Stressen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Wistaren_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSelf Administrationen_HK
dc.subject.meshSpecimen Handlingen_HK
dc.subject.meshStaining and Labelingen_HK
dc.subject.meshThiobarbituric Acid Reactive Substances - metabolismen_HK
dc.titleA voluntary oral-feeding rat model for pathological alcoholic liver injuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1064-3745&volume=447&spage=11&epage=31&date=2008&atitle=A+voluntary+oral-feeding+rat+model+for+pathological+alcoholic+liver+injuryen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-1-59745-242-7-2en_HK
dc.identifier.pmid18369908en_HK
dc.identifier.scopuseid_2-s2.0-43549083079en_HK
dc.identifier.hkuros141690en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43549083079&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume447en_HK
dc.identifier.spage11en_HK
dc.identifier.epage31en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridLiong, EC=6602732210en_HK
dc.identifier.scopusauthoridLeung, TM=7202110149en_HK
dc.identifier.scopusauthoridNanji, AA=35885060300en_HK

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