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Article: Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum

TitleCytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum
Authors
KeywordsCytoprotective effects
Endoplasmic reticulum
Lycium barbarum
Reducing stress
Issue Date2006
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm
Citation
International Journal Of Molecular Medicine, 2006, v. 17 n. 6, p. 1157-1161 How to Cite?
AbstractChinese medicinal herbs have been consumed for thousands of years for the purpose of healthy aging. Lycium barbarum is valued in Chinese culture for its benefits to anti-aging, vision, kidney and liver. Recent studies showed that extracts from L. barbarum possess biological activities including anti-aging, anti-tumor, immune-stimulatory and cytoprotection. Most of these studies emphasized that the protective function of L. barbarum is due to its anti-oxidative effects. We have previously demonstrated that extract from L. barbarum can protect neurons against β-amyloid (Aβ) peptide-induced apoptosis. Since Aβ toxicity may be mediated via oxidative stress, it is still unclear whether the extract from L. barbarum is a simple anti-oxidant exhibiting cytoprotective effects. We hypothesized that extract from L. barbarum is not simply an anti-oxidant in order to function as a neuroprotective agent. The aim of this study is to investigate whether the extract from L. barbarum (LBG) protect neurons via mechanisms independent of anti-oxidative effects. Using a reducing agent, dithiothreitol (DTT), we found that LBG exhibits cytoprotective effects against reducing stress by lowering the DTT-induced LDH release and caspase-3 activity. DTT can trigger endoplasmic reticulum (ER) stress leading to PKR-like ER kinase (PERK) activation. We also showed that LBG attenuates DTT-induced PERK phosphorylation. The extract from L. barbarum is not simply an anti-oxidant; it can also exhibit cytoprotective effects against reducing stress by DTT.
Persistent Identifierhttp://hdl.handle.net/10722/67474
ISSN
2015 Impact Factor: 2.348
2015 SCImago Journal Rankings: 0.868
References

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorHo, YSen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-06T05:55:27Z-
dc.date.available2010-09-06T05:55:27Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal Of Molecular Medicine, 2006, v. 17 n. 6, p. 1157-1161en_HK
dc.identifier.issn1107-3756en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67474-
dc.description.abstractChinese medicinal herbs have been consumed for thousands of years for the purpose of healthy aging. Lycium barbarum is valued in Chinese culture for its benefits to anti-aging, vision, kidney and liver. Recent studies showed that extracts from L. barbarum possess biological activities including anti-aging, anti-tumor, immune-stimulatory and cytoprotection. Most of these studies emphasized that the protective function of L. barbarum is due to its anti-oxidative effects. We have previously demonstrated that extract from L. barbarum can protect neurons against β-amyloid (Aβ) peptide-induced apoptosis. Since Aβ toxicity may be mediated via oxidative stress, it is still unclear whether the extract from L. barbarum is a simple anti-oxidant exhibiting cytoprotective effects. We hypothesized that extract from L. barbarum is not simply an anti-oxidant in order to function as a neuroprotective agent. The aim of this study is to investigate whether the extract from L. barbarum (LBG) protect neurons via mechanisms independent of anti-oxidative effects. Using a reducing agent, dithiothreitol (DTT), we found that LBG exhibits cytoprotective effects against reducing stress by lowering the DTT-induced LDH release and caspase-3 activity. DTT can trigger endoplasmic reticulum (ER) stress leading to PKR-like ER kinase (PERK) activation. We also showed that LBG attenuates DTT-induced PERK phosphorylation. The extract from L. barbarum is not simply an anti-oxidant; it can also exhibit cytoprotective effects against reducing stress by DTT.en_HK
dc.languageengen_HK
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htmen_HK
dc.relation.ispartofInternational Journal of Molecular Medicineen_HK
dc.subjectCytoprotective effectsen_HK
dc.subjectEndoplasmic reticulumen_HK
dc.subjectLycium barbarumen_HK
dc.subjectReducing stressen_HK
dc.titleCytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1107-3756&volume=17&spage=1157&epage=1161&date=2006&atitle=Cytoprotective+effects+of+Lycium+barbarum+against+reducing+stress+on+endoplasmic+reticulum.en_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.scopuseid_2-s2.0-33745699553en_HK
dc.identifier.hkuros148333en_HK
dc.identifier.hkuros117294-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745699553&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1157en_HK
dc.identifier.epage1161en_HK
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridYu, MS=35346047600en_HK
dc.identifier.scopusauthoridHo, YS=14031513600en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYuen, WH=7102761282en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK

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