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Article: Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection

TitleGreen tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection
Authors
KeywordsAnti-inflammation
Anti-oxidant
Cardiovascular
Epigallocatechin gallate (EGCG)
Oxidative stress
Reactive oxygen species
Issue Date2007
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtchd
Citation
Cardiovascular And Hematological Disorders - Drug Targets, 2007, v. 7 n. 2, p. 135-144 How to Cite?
AbstractOur review aims to examine the cellular and molecular mechanisms of cardiovascular protection of green tea polyphenols, particularly epigallocatechin gallate (EGCG), which focuses on the anti-oxidative and anti-inflammatory effects. EGCG is the major and the most active component in green tea. Studies have shown that EGCG protects cellular damage by inhibiting DNA damage and oxidation of LDL. One of the protective properties of EGCG is its ability to scavenge free radicals. EGCG can also reduce the inflammatory response associated with local tissue injuries such as the hepatocellular necrosis in acute liver injury induced by carbon tetrachloride. The protective effect of EGCG is due to its ability to decrease lipid peroxidation, oxidative stress and the production of nitric oxide (NO) radicals by inhibiting the expression of iNOS. EGCG also ameliorates the overproduction of pro-inflammatory cytokines and mediators, reduces the activity of NF-κB and AP-1 and the subsequent formation of peroxynitrite with NO and reactive oxygen species. Thus, EGCG effectively mitigates cellular damage by lowering the inflammatory reaction and reducing the lipid peroxidation and NO generated radicals leading to the oxidative stress. Green tea is proposed to be a dietary supplement in the prevention of cardiovascular diseases in which oxidative stress and proinflammation are the principal causes. © 2007 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/67472
ISSN
2015 SCImago Journal Rankings: 0.718
References

 

DC FieldValueLanguage
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorLeung, TMen_HK
dc.contributor.authorHung, MWen_HK
dc.contributor.authorFung, MLen_HK
dc.date.accessioned2010-09-06T05:55:26Z-
dc.date.available2010-09-06T05:55:26Z-
dc.date.issued2007en_HK
dc.identifier.citationCardiovascular And Hematological Disorders - Drug Targets, 2007, v. 7 n. 2, p. 135-144en_HK
dc.identifier.issn1871-529Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67472-
dc.description.abstractOur review aims to examine the cellular and molecular mechanisms of cardiovascular protection of green tea polyphenols, particularly epigallocatechin gallate (EGCG), which focuses on the anti-oxidative and anti-inflammatory effects. EGCG is the major and the most active component in green tea. Studies have shown that EGCG protects cellular damage by inhibiting DNA damage and oxidation of LDL. One of the protective properties of EGCG is its ability to scavenge free radicals. EGCG can also reduce the inflammatory response associated with local tissue injuries such as the hepatocellular necrosis in acute liver injury induced by carbon tetrachloride. The protective effect of EGCG is due to its ability to decrease lipid peroxidation, oxidative stress and the production of nitric oxide (NO) radicals by inhibiting the expression of iNOS. EGCG also ameliorates the overproduction of pro-inflammatory cytokines and mediators, reduces the activity of NF-κB and AP-1 and the subsequent formation of peroxynitrite with NO and reactive oxygen species. Thus, EGCG effectively mitigates cellular damage by lowering the inflammatory reaction and reducing the lipid peroxidation and NO generated radicals leading to the oxidative stress. Green tea is proposed to be a dietary supplement in the prevention of cardiovascular diseases in which oxidative stress and proinflammation are the principal causes. © 2007 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtchden_HK
dc.relation.ispartofCardiovascular and Hematological Disorders - Drug Targetsen_HK
dc.subjectAnti-inflammationen_HK
dc.subjectAnti-oxidanten_HK
dc.subjectCardiovascularen_HK
dc.subjectEpigallocatechin gallate (EGCG)en_HK
dc.subjectOxidative stressen_HK
dc.subjectReactive oxygen speciesen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidalen_HK
dc.subject.meshAntioxidantsen_HK
dc.subject.meshCardiotonic Agentsen_HK
dc.subject.meshCardiovascular Diseases - prevention & controlen_HK
dc.subject.meshFlavonoids - pharmacologyen_HK
dc.subject.meshFree Radical Scavengers - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshOxidative Stress - drug effectsen_HK
dc.subject.meshPhenols - pharmacologyen_HK
dc.subject.meshPolyphenolsen_HK
dc.subject.meshTea - chemistryen_HK
dc.titleGreen tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1871-529X&volume=7&issue=2&spage=135&epage=144&date=2007&atitle=Green+tea+polyphenols+as+an+anti-oxidant+and+anti-inflammatory+agent+for+cardiovascular+protectionen_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17584048-
dc.identifier.scopuseid_2-s2.0-34347381789en_HK
dc.identifier.hkuros137813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347381789&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue2en_HK
dc.identifier.spage135en_HK
dc.identifier.epage144en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridLeung, TM=7202110149en_HK
dc.identifier.scopusauthoridHung, MW=16744402300en_HK
dc.identifier.scopusauthoridFung, ML=7101955092en_HK

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