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Article: Cyclosporine affects the proliferation and differentiation of neural stem cells in culture

TitleCyclosporine affects the proliferation and differentiation of neural stem cells in culture
Authors
KeywordsCyclosporine
Differentiation
Neural stem cells
Proliferation
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2007, v. 18 n. 9, p. 863-868 How to Cite?
AbstractCyclosporine is one of the foremost immunosuppressive agents for cell, tissue, and organ transplantation. Cyclosporine is, however, associated with significant side effects in the host, and may also affect the fate of the donor cells. This study was performed to test whether cyclosporine may change the fate of neural stem cells, as neural stem cell transplant has become a potential treatment for neurological disorders and damage. Results of this study showed that cyclosporine inhibited the proliferation significantly in a dosage-dependent manner. Cyclosporine also affected the differentiation of neural stem cells, which mainly increased astrocyte genesis and decreased neuron differentiation. © 2007 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67470
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Jen_HK
dc.contributor.authorZeng, Yen_HK
dc.contributor.authorLiang, Yen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorSu, Hen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:55:25Z-
dc.date.available2010-09-06T05:55:25Z-
dc.date.issued2007en_HK
dc.identifier.citationNeuroreport, 2007, v. 18 n. 9, p. 863-868en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67470-
dc.description.abstractCyclosporine is one of the foremost immunosuppressive agents for cell, tissue, and organ transplantation. Cyclosporine is, however, associated with significant side effects in the host, and may also affect the fate of the donor cells. This study was performed to test whether cyclosporine may change the fate of neural stem cells, as neural stem cell transplant has become a potential treatment for neurological disorders and damage. Results of this study showed that cyclosporine inhibited the proliferation significantly in a dosage-dependent manner. Cyclosporine also affected the differentiation of neural stem cells, which mainly increased astrocyte genesis and decreased neuron differentiation. © 2007 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroReport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectCyclosporineen_HK
dc.subjectDifferentiationen_HK
dc.subjectNeural stem cellsen_HK
dc.subjectProliferationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntimetabolites - pharmacologyen_HK
dc.subject.meshBromodeoxyuridine - pharmacologyen_HK
dc.subject.meshCell Counten_HK
dc.subject.meshCell Differentiation - drug effectsen_HK
dc.subject.meshCell Proliferation - drug effectsen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshCyclosporine - pharmacologyen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunosuppressive Agents - pharmacologyen_HK
dc.subject.meshNeurons - drug effectsen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStem Cells - drug effectsen_HK
dc.titleCyclosporine affects the proliferation and differentiation of neural stem cells in cultureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=18&issue=9&spage=863&epage=868&date=2007&atitle=Cyclosporine+affects+the+proliferation+and+differentiation+of+neural+stem+cells+in+cultureen_HK
dc.identifier.emailLiang, Y: yxliang@hkucc.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.authorityLiang, Y=rp00510en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/WNR.0b013e32811d6d36en_HK
dc.identifier.pmid17515791-
dc.identifier.scopuseid_2-s2.0-34248993178en_HK
dc.identifier.hkuros137865en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248993178&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue9en_HK
dc.identifier.spage863en_HK
dc.identifier.epage868en_HK
dc.identifier.isiWOS:000247042200005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuo, J=7404488603en_HK
dc.identifier.scopusauthoridZeng, Y=8236229300en_HK
dc.identifier.scopusauthoridLiang, Y=55479398500en_HK
dc.identifier.scopusauthoridWang, L=36851780300en_HK
dc.identifier.scopusauthoridSu, H=16317750200en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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