File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Molecular repair of the brain using self-assembling peptides

TitleMolecular repair of the brain using self-assembling peptides
Authors
Issue Date2006
PublisherTekno Scienze. The Journal's web site is located at http://chemistry-today.teknoscienze.com/index.asp
Citation
Chimica Oggi, 2006, v. 24 n. 4, p. 42-45 How to Cite?
AbstractThe brain is a self-assembled network of connections and tissue. During the assembly process there are many changes, some are minute some are system-wide. The final system-wide change that occurs is when an injured brain blocks regeneration. Until recently self-assembly has never been used to repair injured brain structures. Using the mammalian visual system as a model for functional return of vision, we demonstrated that a designed self-assembling peptide nanofiber scaffold created a permissive environment not only for axons to regenerate through the site of an acute injury, but also to knit the brain tissue together. In experiments using a severed optic tract in the hamster, we showed that regenerated axons reconnected to tarnet tissues with sufficient density to promote functional return of vision, as evidenced by visually elicited orienting behaviour. The peptide nanofiber scaffold not only represents a new nanobiomedical technology for tissue repair and restoration, but also raises the possibility of effective treatment of central nervous system and other tissue or organ trauma.
Persistent Identifierhttp://hdl.handle.net/10722/67463
ISSN
2015 Impact Factor: 0.538
2015 SCImago Journal Rankings: 0.247
References

 

DC FieldValueLanguage
dc.contributor.authorEllisBehnke, Ren_HK
dc.contributor.authorKwokFai, SOen_HK
dc.contributor.authorZhang, Sen_HK
dc.date.accessioned2010-09-06T05:55:21Z-
dc.date.available2010-09-06T05:55:21Z-
dc.date.issued2006en_HK
dc.identifier.citationChimica Oggi, 2006, v. 24 n. 4, p. 42-45en_HK
dc.identifier.issn0392-839Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67463-
dc.description.abstractThe brain is a self-assembled network of connections and tissue. During the assembly process there are many changes, some are minute some are system-wide. The final system-wide change that occurs is when an injured brain blocks regeneration. Until recently self-assembly has never been used to repair injured brain structures. Using the mammalian visual system as a model for functional return of vision, we demonstrated that a designed self-assembling peptide nanofiber scaffold created a permissive environment not only for axons to regenerate through the site of an acute injury, but also to knit the brain tissue together. In experiments using a severed optic tract in the hamster, we showed that regenerated axons reconnected to tarnet tissues with sufficient density to promote functional return of vision, as evidenced by visually elicited orienting behaviour. The peptide nanofiber scaffold not only represents a new nanobiomedical technology for tissue repair and restoration, but also raises the possibility of effective treatment of central nervous system and other tissue or organ trauma.en_HK
dc.languageengen_HK
dc.publisherTekno Scienze. The Journal's web site is located at http://chemistry-today.teknoscienze.com/index.aspen_HK
dc.relation.ispartofChimica Oggien_HK
dc.titleMolecular repair of the brain using self-assembling peptidesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0392-839X&volume=24&issue=4&spage=42&epage=43&date=2006&atitle=Molecular+repair+of+the+brain+using+self-assembling+peptidesen_HK
dc.identifier.emailEllisBehnke, R: rutledg@mit.eduen_HK
dc.identifier.emailKwokFai, SO: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, R=rp00252en_HK
dc.identifier.authorityKwokFai, SO=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33749168553en_HK
dc.identifier.hkuros125782en_HK
dc.identifier.hkuros124244-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749168553&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue4en_HK
dc.identifier.spage42en_HK
dc.identifier.epage45en_HK
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridEllisBehnke, R=8548055200en_HK
dc.identifier.scopusauthoridKwokFai, SO=34668391300en_HK
dc.identifier.scopusauthoridZhang, S=7409370463en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats