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Article: Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer

TitleGarlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer
Authors
Issue Date2007
PublisherAmerican Association for Cancer Research.
Citation
Clinical Cancer Research, 2007, v. 13 n. 6, p. 1847-1856 How to Cite?
AbstractPurpose: There is epidemiologic evidence that high garlic consumption decreases the incidence of prostate cancer, and compounds isolated from garlic have been shown to have cancer-preventive and tumor-suppressive effects. Recent in vitro studies in our laboratory have shown that garlic-derived organosulfur compound S-allylmercaptocysteine suppresses invasion and cell motility of androgen-independent prostate cancer cells via the up-regulation of cell-adhesion molecule E-cadherin. S-allylmercaptocysteine is therefore a potential antimetastatic drug with broad clinical applications that we tested in vivo for the first time in this study. Experimental Design: We used a newly established fluorescent orthotopic androgen-independent prostate cancer mouse model to assess the ability of S-allylmercaptocysteine to inhibit tumor growth and dissemination. Results: We showed that oral S-allylmercaptocysteine not only inhibited the growth of primary tumors by up to 71% (P < 0.001) but also reduced the number of lung and adrenal metastases by as much as 85.5% (P = 0.001) without causing notable toxicity. This metastatic suppression was accompanied by a 91% reduction of viable circulating tumor cells (P = 0.041), suggesting that S-allylmercaptocysteine prevents dissemination by decreasing tumor cell intravasation. Conclusions: Our results provide in vivo evidence supporting the potential use of S-allylmercaptocysteine as an E-cadherin up-regulating antimetastatic agent for the treatment of androgen-independent prostate cancer. This is the first report of the in vivo antimetastatic properties of garlic, which may also apply to other cancer types. ©2007 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/67456
ISSN
2015 Impact Factor: 8.738
2015 SCImago Journal Rankings: 5.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHoward, EWen_HK
dc.contributor.authorLing, MTen_HK
dc.contributor.authorChee, WCen_HK
dc.contributor.authorHiu, WCen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorYong, CWen_HK
dc.date.accessioned2010-09-06T05:55:18Z-
dc.date.available2010-09-06T05:55:18Z-
dc.date.issued2007en_HK
dc.identifier.citationClinical Cancer Research, 2007, v. 13 n. 6, p. 1847-1856en_HK
dc.identifier.issn1078-0432en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67456-
dc.description.abstractPurpose: There is epidemiologic evidence that high garlic consumption decreases the incidence of prostate cancer, and compounds isolated from garlic have been shown to have cancer-preventive and tumor-suppressive effects. Recent in vitro studies in our laboratory have shown that garlic-derived organosulfur compound S-allylmercaptocysteine suppresses invasion and cell motility of androgen-independent prostate cancer cells via the up-regulation of cell-adhesion molecule E-cadherin. S-allylmercaptocysteine is therefore a potential antimetastatic drug with broad clinical applications that we tested in vivo for the first time in this study. Experimental Design: We used a newly established fluorescent orthotopic androgen-independent prostate cancer mouse model to assess the ability of S-allylmercaptocysteine to inhibit tumor growth and dissemination. Results: We showed that oral S-allylmercaptocysteine not only inhibited the growth of primary tumors by up to 71% (P < 0.001) but also reduced the number of lung and adrenal metastases by as much as 85.5% (P = 0.001) without causing notable toxicity. This metastatic suppression was accompanied by a 91% reduction of viable circulating tumor cells (P = 0.041), suggesting that S-allylmercaptocysteine prevents dissemination by decreasing tumor cell intravasation. Conclusions: Our results provide in vivo evidence supporting the potential use of S-allylmercaptocysteine as an E-cadherin up-regulating antimetastatic agent for the treatment of androgen-independent prostate cancer. This is the first report of the in vivo antimetastatic properties of garlic, which may also apply to other cancer types. ©2007 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research.en_HK
dc.relation.ispartofClinical Cancer Researchen_HK
dc.subject.meshAndrogens - pharmacologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntineoplastic Agents - therapeutic useen_HK
dc.subject.meshAntineoplastic Agents, Hormonal - pharmacologyen_HK
dc.subject.meshCysteine - analogs & derivatives - therapeutic useen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDrug Evaluation, Preclinicalen_HK
dc.subject.meshDrug Resistance, Neoplasm - drug effectsen_HK
dc.subject.meshGarlic - chemistryen_HK
dc.subject.meshGreen Fluorescent Proteins - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, SCIDen_HK
dc.subject.meshNeoplasm Metastasis - prevention & controlen_HK
dc.subject.meshProstatic Neoplasms - drug therapy - pathologyen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.subject.meshXenograft Model Antitumor Assaysen_HK
dc.titleGarlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-0432&volume=13&issue=6&spage=1847&epage=1856&date=2007&atitle=Garlic-derived+S-allylmercaptocysteine+is+a+novel+In+vivo+antimetastatic+agent+for+androgen-independent+prostate+canceren_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.emailYong, CW:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.identifier.authorityYong, CW=rp00316en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/1078-0432.CCR-06-2074en_HK
dc.identifier.pmid17363541-
dc.identifier.scopuseid_2-s2.0-34250191113en_HK
dc.identifier.hkuros147778en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250191113&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1847en_HK
dc.identifier.epage1856en_HK
dc.identifier.isiWOS:000245031800034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHoward, EW=16480736900en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK
dc.identifier.scopusauthoridChee, WC=16642230300en_HK
dc.identifier.scopusauthoridHiu, WC=6506527813en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridYong, CW=7403041798en_HK

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