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Article: Enhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts

TitleEnhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts
Authors
KeywordsGinkgo biloba
Hypericum perforatum
Neuroprotection
Optic nerve
Panax quinquefolius L.
Issue Date2002
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
Citation
Journal Of Neurotrauma, 2002, v. 19 n. 3, p. 369-378 How to Cite?
AbstractThe aim of this study is to investigate the effects of Panax quinquefolius L. extract (PQE), Ginkgo biloba extract (GBE), and Hypericum perforatum extract (HPE), in combination or alone, on the survival and regeneration of axotomized retinal ganglion cells (RGCs) in an optic nerve transection model in adult hamsters. Unilateral transection of the optic nerve was performed to evaluate the effects of herbal extracts on the survival of axotomized RGCs. Effects of the herbal extracts on axonal regeneration of axotomized RGCs, on the other hand, were studied by attaching a peripheral nerve graft onto the transected ocular stump to induce regeneration. Operated animals received daily oral administration of vehicle or herbal extracts (PQE, GBE, and HPE), alone or in combination, for 7 and 21 days, respectively, in the survival and regeneration experiments. Surviving and regenerating RGCs were retrogradely labeled with Fluoro-Gold. The eyes were then enucleated and the retinas were flat-mounted for the counting of the labeled RGCs. Treatment with PQE, GBE and HPE alone failed to offer neuroprotection to injured RGCs. However, treatment with Menta-FX, a mixture of PQE, GBE, and HPE, significantly augmented RGC survival 7 days postaxotomy. Treatment with Menta-FX also induced a significant (87%) increase in the number of regenerating RGCs 21 days after optic nerve transection. This study demonstrates that herbs can act as a potential neuroprotective agent for damaged RGCs. It also suggests that the therapeutic value of herbal remedies can be maximized by the use of mixtures of appropriate herbs.
Persistent Identifierhttp://hdl.handle.net/10722/67454
ISSN
2015 Impact Factor: 4.377
2015 SCImago Journal Rankings: 1.945
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorLu, Qen_HK
dc.contributor.authorYip, HKen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorShan, JJen_HK
dc.contributor.authorPang, PKTen_HK
dc.contributor.authorChen, CFen_HK
dc.date.accessioned2010-09-06T05:55:16Z-
dc.date.available2010-09-06T05:55:16Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Neurotrauma, 2002, v. 19 n. 3, p. 369-378en_HK
dc.identifier.issn0897-7151en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67454-
dc.description.abstractThe aim of this study is to investigate the effects of Panax quinquefolius L. extract (PQE), Ginkgo biloba extract (GBE), and Hypericum perforatum extract (HPE), in combination or alone, on the survival and regeneration of axotomized retinal ganglion cells (RGCs) in an optic nerve transection model in adult hamsters. Unilateral transection of the optic nerve was performed to evaluate the effects of herbal extracts on the survival of axotomized RGCs. Effects of the herbal extracts on axonal regeneration of axotomized RGCs, on the other hand, were studied by attaching a peripheral nerve graft onto the transected ocular stump to induce regeneration. Operated animals received daily oral administration of vehicle or herbal extracts (PQE, GBE, and HPE), alone or in combination, for 7 and 21 days, respectively, in the survival and regeneration experiments. Surviving and regenerating RGCs were retrogradely labeled with Fluoro-Gold. The eyes were then enucleated and the retinas were flat-mounted for the counting of the labeled RGCs. Treatment with PQE, GBE and HPE alone failed to offer neuroprotection to injured RGCs. However, treatment with Menta-FX, a mixture of PQE, GBE, and HPE, significantly augmented RGC survival 7 days postaxotomy. Treatment with Menta-FX also induced a significant (87%) increase in the number of regenerating RGCs 21 days after optic nerve transection. This study demonstrates that herbs can act as a potential neuroprotective agent for damaged RGCs. It also suggests that the therapeutic value of herbal remedies can be maximized by the use of mixtures of appropriate herbs.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neuen_HK
dc.relation.ispartofJournal of Neurotraumaen_HK
dc.rightsThis is a copy of an article published in the Journal of Neurotrauma © 2002 [copyright Mary Ann Liebert, Inc.]; Journal of Neurotrauma is available online at: http://www.liebertonline.com.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectGinkgo bilobaen_HK
dc.subjectHypericum perforatumen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectOptic nerveen_HK
dc.subjectPanax quinquefolius L.en_HK
dc.subject.meshCell Survival - drug effects-
dc.subject.meshGinkgo biloba-
dc.subject.meshHypericum-
dc.subject.meshNerve Regeneration - drug effects-
dc.subject.meshRetinal Ganglion Cells - drug effects-
dc.titleEnhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extractsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/089771502753594936-
dc.identifier.pmid11939504-
dc.identifier.scopuseid_2-s2.0-0036127977en_HK
dc.identifier.hkuros65771en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036127977&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue3en_HK
dc.identifier.spage369en_HK
dc.identifier.epage378en_HK
dc.identifier.isiWOS:000174563900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridLu, Q=54902894100en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridShan, JJ=35075019400en_HK
dc.identifier.scopusauthoridPang, PKT=24489141500en_HK
dc.identifier.scopusauthoridChen, CF=7501960161en_HK

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