File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Intravitreal transplantation of a segment of peripheral nerve enhances axonal regeneration of retinal ganglion cells following distal axotomy

TitleIntravitreal transplantation of a segment of peripheral nerve enhances axonal regeneration of retinal ganglion cells following distal axotomy
Authors
Issue Date1994
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 1994, v. 128 n. 2, p. 211-215 How to Cite?
AbstractNeurons of the central nervous system are able to regenerate their axons into a peripheral nerve (PN) graft when they are axotomized close to the cell bodies. Very few, if any, damaged axons can regrow into the PN graft when the axonal injury is made distant to the cell bodies. We show here that a segment of viable PN transplanted intravitreally enhances the regenerative response of distally axotomized retinal ganglion cells. We hypothesize that trophic substances released from the intravitreal PN segment may enable retinal ganglion cells to regenerate their damaged axons into the PN graft even after a distal axotomy. This suggests that the regenerative behavior of an axotomixed neuron is influenced by both the local environment at the damaged tip of the axon and the local environment surrounding the cell body. This finding provides evidence that the PN grafting technique may be useful for repairing long tract pathways in the central nervous system even when the damage is inflicted far away from the cell bodies.
Persistent Identifierhttp://hdl.handle.net/10722/67437
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, KCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorTay, Den_HK
dc.date.accessioned2010-09-06T05:55:08Z-
dc.date.available2010-09-06T05:55:08Z-
dc.date.issued1994en_HK
dc.identifier.citationExperimental Neurology, 1994, v. 128 n. 2, p. 211-215en_HK
dc.identifier.issn0014-4886en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67437-
dc.description.abstractNeurons of the central nervous system are able to regenerate their axons into a peripheral nerve (PN) graft when they are axotomized close to the cell bodies. Very few, if any, damaged axons can regrow into the PN graft when the axonal injury is made distant to the cell bodies. We show here that a segment of viable PN transplanted intravitreally enhances the regenerative response of distally axotomized retinal ganglion cells. We hypothesize that trophic substances released from the intravitreal PN segment may enable retinal ganglion cells to regenerate their damaged axons into the PN graft even after a distal axotomy. This suggests that the regenerative behavior of an axotomixed neuron is influenced by both the local environment at the damaged tip of the axon and the local environment surrounding the cell body. This finding provides evidence that the PN grafting technique may be useful for repairing long tract pathways in the central nervous system even when the damage is inflicted far away from the cell bodies.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_HK
dc.relation.ispartofExperimental Neurologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - physiologyen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshDenervationen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshPeripheral Nerves - transplantationen_HK
dc.subject.meshRetinal Ganglion Cells - physiologyen_HK
dc.subject.meshTransplantation, Heterotopicen_HK
dc.subject.meshVitreous Body - physiologyen_HK
dc.titleIntravitreal transplantation of a segment of peripheral nerve enhances axonal regeneration of retinal ganglion cells following distal axotomyen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityTay, D=rp00336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/exnr.1994.1129en_HK
dc.identifier.pmid8076664-
dc.identifier.scopuseid_2-s2.0-0027986665en_HK
dc.identifier.hkuros4612en_HK
dc.identifier.volume128en_HK
dc.identifier.issue2en_HK
dc.identifier.spage211en_HK
dc.identifier.epage215en_HK
dc.identifier.isiWOS:A1994PE96300006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, KC=16407204200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridTay, D=7006796825en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats