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Article: Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines

TitleGrowth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines
Authors
Issue Date2003
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2003, v. 116 n. 11, p. 1673-1677 How to Cite?
AbstractObjective. To study the effects of an α1-adrenoceptor antagonist, terazosin on the androgen-independent prostate cancer cell lines PC-3 and DU145. Methods. Two androgen independent cell lines, PC-3 and DU145, were used to determine cell viability, colony-forming ability, as well as cell cycle distribution, after exposure to terazosin. Western blot analysis was used to determine the expression of p21WAF1 and p27KIP1. Results. This study shows that terazosin inhibits not only prostate cancer cell growth but also its colony forming ability, both of which are main targets of clinical treatment. In addition, terazosin is shown to inhibit cell growth through G1 phase cell cycle arrest and the up-regulation of p27KIP1. Conclusion. This study provides evidence that the α1-adrenoceptor antagonist terazosin may have therapeutic potential in the treatment of advanced hormone refractory prostate cancer.
Persistent Identifierhttp://hdl.handle.net/10722/67435
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Ken_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorLing, Men_HK
dc.contributor.authorWong, Yen_HK
dc.date.accessioned2010-09-06T05:55:07Z-
dc.date.available2010-09-06T05:55:07Z-
dc.date.issued2003en_HK
dc.identifier.citationChinese Medical Journal, 2003, v. 116 n. 11, p. 1673-1677en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67435-
dc.description.abstractObjective. To study the effects of an α1-adrenoceptor antagonist, terazosin on the androgen-independent prostate cancer cell lines PC-3 and DU145. Methods. Two androgen independent cell lines, PC-3 and DU145, were used to determine cell viability, colony-forming ability, as well as cell cycle distribution, after exposure to terazosin. Western blot analysis was used to determine the expression of p21WAF1 and p27KIP1. Results. This study shows that terazosin inhibits not only prostate cancer cell growth but also its colony forming ability, both of which are main targets of clinical treatment. In addition, terazosin is shown to inhibit cell growth through G1 phase cell cycle arrest and the up-regulation of p27KIP1. Conclusion. This study provides evidence that the α1-adrenoceptor antagonist terazosin may have therapeutic potential in the treatment of advanced hormone refractory prostate cancer.en_HK
dc.languageengen_HK
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subject.meshAdrenergic alpha-Antagonists - pharmacologyen_HK
dc.subject.meshAntineoplastic Agents - pharmacologyen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPrazosin - analogs & derivatives - pharmacologyen_HK
dc.subject.meshProstatic Neoplasms - pathologyen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.titleGrowth inhibiting effects of terazosin on androgen-independent prostate cancer cell linesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0366-6999&volume=116&spage=1673&epage=1677&date=2003&atitle=Growth+inhibiting+effects+of+terazosin+on+androgen-independent+prostate+cancer+cell+linesen_HK
dc.identifier.emailLing, M:patling@hkucc.hku.hken_HK
dc.identifier.emailWong, Y:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityLing, M=rp00449en_HK
dc.identifier.authorityWong, Y=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid14642133en_HK
dc.identifier.scopuseid_2-s2.0-0346896393en_HK
dc.identifier.hkuros88937en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346896393&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume116en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1673en_HK
dc.identifier.epage1677en_HK
dc.identifier.isiWOS:000187462900009-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridXu, K=7403282051en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridLing, M=7102229780en_HK
dc.identifier.scopusauthoridWong, Y=7403041798en_HK

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