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Article: The study on the sciatic nerve graft inducing axonal regeneration of the neurons in motor cortex and brainstem in adult hamsters

TitleThe study on the sciatic nerve graft inducing axonal regeneration of the neurons in motor cortex and brainstem in adult hamsters
金黃地鼠坐骨神經移植段誘導運動皮質細胞和腦干神經元軸突再生的研究
Authors
Issue Date1995
PublisherBeijing Medical University (北京醫科大學).
Citation
Journal of Beijing Medical University, 1995, v. 27 n. 1, p. 19-22 How to Cite?
北京醫科大學學報, 1995, v. 27 n. 1, p. 19-22 How to Cite?
AbstractA segment of the right sciatic nerve was transplanted into medulla pyramidal decussation and concurrently sev-eral short segments of the left sciatic nerve were inserted into the motor cortex.Eight weeks later,1μl of 20% so-lution of HRP was injected into the sciatic nerve graft placed in the medulla.The HRP Iabelled cells were found inthe brainstem and diencephalon,but none was present in the motor cortex. Most of labelled cells were concentrat-ed around the grafting site.The number of labelled cells decreased rapidiy with increasing distance from the site ofgraft insertion。Thus,the results suggest that the insertion of the short sciatic nerve grafts near the pyramidal cellbodies do not enhance regeneration of the neurons in the motor cortex,and the ability of the damaged axons togrow into the graft partly depends on the location of the cell bodies from the site of axotomy and the sciatic nervegraft.
將右側坐骨神經植入金黃地鼠的延髓錐體交叉處,同時,又將左側坐骨神經切成數個短段后全段植入運動皮質。8周后用辣根過氧化物酶(HRP)軸突逆行追蹤法觀察HRP標記的軸突再生中樞神經元。結果,各組的運動皮質內均未發現標記細胞,在腦干和間腦可見標記細胞,呈距移植神經越遠標記細胞越少的分布趨勢。提示:植入錐體細胞胞體周圍的坐骨神經短段對遠距胞體的軸突損傷后再生無明顯促進作用,腦干神經元的軸突再生與移植神經插入及軸突損傷部位距神經元胞體之間的距離密切相關。
Persistent Identifierhttp://hdl.handle.net/10722/67424
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChen, Qen_HK
dc.contributor.authorTay, KCen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:55:01Z-
dc.date.available2010-09-06T05:55:01Z-
dc.date.issued1995en_HK
dc.identifier.citationJournal of Beijing Medical University, 1995, v. 27 n. 1, p. 19-22en_HK
dc.identifier.citation北京醫科大學學報, 1995, v. 27 n. 1, p. 19-22-
dc.identifier.issn1000-1530en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67424-
dc.description.abstractA segment of the right sciatic nerve was transplanted into medulla pyramidal decussation and concurrently sev-eral short segments of the left sciatic nerve were inserted into the motor cortex.Eight weeks later,1μl of 20% so-lution of HRP was injected into the sciatic nerve graft placed in the medulla.The HRP Iabelled cells were found inthe brainstem and diencephalon,but none was present in the motor cortex. Most of labelled cells were concentrat-ed around the grafting site.The number of labelled cells decreased rapidiy with increasing distance from the site ofgraft insertion。Thus,the results suggest that the insertion of the short sciatic nerve grafts near the pyramidal cellbodies do not enhance regeneration of the neurons in the motor cortex,and the ability of the damaged axons togrow into the graft partly depends on the location of the cell bodies from the site of axotomy and the sciatic nervegraft.-
dc.description.abstract將右側坐骨神經植入金黃地鼠的延髓錐體交叉處,同時,又將左側坐骨神經切成數個短段后全段植入運動皮質。8周后用辣根過氧化物酶(HRP)軸突逆行追蹤法觀察HRP標記的軸突再生中樞神經元。結果,各組的運動皮質內均未發現標記細胞,在腦干和間腦可見標記細胞,呈距移植神經越遠標記細胞越少的分布趨勢。提示:植入錐體細胞胞體周圍的坐骨神經短段對遠距胞體的軸突損傷后再生無明顯促進作用,腦干神經元的軸突再生與移植神經插入及軸突損傷部位距神經元胞體之間的距離密切相關。-
dc.languagechien_HK
dc.publisherBeijing Medical University (北京醫科大學).en_HK
dc.relation.ispartofJournal of Beijing Medical Universityen_HK
dc.relation.ispartof北京醫科大學學報-
dc.subject.meshHeadings Nerve pegeneration (神經再生)-
dc.subject.meshAxons (軸突)-
dc.subject.meshPyramidal cells (錐體細胞)-
dc.subject.meshSciatic nerve/transpl (坐骨神經/移植)-
dc.subject.meshBrain stem (腦干)-
dc.titleThe study on the sciatic nerve graft inducing axonal regeneration of the neurons in motor cortex and brainstem in adult hamstersen_HK
dc.title金黃地鼠坐骨神經移植段誘導運動皮質細胞和腦干神經元軸突再生的研究-
dc.typeArticleen_HK
dc.identifier.emailTay, KC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros4609en_HK
dc.identifier.volume27-
dc.identifier.issue1-
dc.identifier.spage19-
dc.identifier.epage22-
dc.publisher.placeBeijing (北京)-

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