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Article: Absence or low number of telomere repeats at junctions of dicentric chromosomes

TitleAbsence or low number of telomere repeats at junctions of dicentric chromosomes
Authors
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
Citation
Genes Chromosomes And Cancer, 1999, v. 24 n. 1, p. 83-86 How to Cite?
AbstractHuman ovarian surface epithelial (HOSE) cells transfected with the E6 and E7 oncogenes of the human papilloma virus (PV) do not express measurable telomerase activity. Relative to untransfected control cells, HOSE-PV cells have an extended in vitro lifespan characterized by a very high frequency of telomeric associations (TAs) of chromosomes. In order to study the role of telomere shortening in the formation of TAs, we studied the telomere length in 120 dicentric chromosomes in HOSE-PV cells by using quantitative fluorescence in situ hybridization. Forty percent of the dicentric chromosomes had no fluorescence signal at the junction site, and in the remainder the fluorescence at the junction was less than at corresponding unjoined ends. These observations support a critical role of telomere shortening in the development of TAs and the subsequent genetic instability observed in a majority of tumor cells.
Persistent Identifierhttp://hdl.handle.net/10722/67419
ISSN
2015 Impact Factor: 3.96
2015 SCImago Journal Rankings: 2.210
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorMartens, UMen_HK
dc.contributor.authorPoon, SSSen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorLansdorp, PMen_HK
dc.date.accessioned2010-09-06T05:54:59Z-
dc.date.available2010-09-06T05:54:59Z-
dc.date.issued1999en_HK
dc.identifier.citationGenes Chromosomes And Cancer, 1999, v. 24 n. 1, p. 83-86en_HK
dc.identifier.issn1045-2257en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67419-
dc.description.abstractHuman ovarian surface epithelial (HOSE) cells transfected with the E6 and E7 oncogenes of the human papilloma virus (PV) do not express measurable telomerase activity. Relative to untransfected control cells, HOSE-PV cells have an extended in vitro lifespan characterized by a very high frequency of telomeric associations (TAs) of chromosomes. In order to study the role of telomere shortening in the formation of TAs, we studied the telomere length in 120 dicentric chromosomes in HOSE-PV cells by using quantitative fluorescence in situ hybridization. Forty percent of the dicentric chromosomes had no fluorescence signal at the junction site, and in the remainder the fluorescence at the junction was less than at corresponding unjoined ends. These observations support a critical role of telomere shortening in the development of TAs and the subsequent genetic instability observed in a majority of tumor cells.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250en_HK
dc.relation.ispartofGenes Chromosomes and Canceren_HK
dc.rightsGenes, Chromosomes & Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescence - methodsen_HK
dc.subject.meshOncogene Proteins, Viral - geneticsen_HK
dc.subject.meshOvaryen_HK
dc.subject.meshPapillomaviridae - geneticsen_HK
dc.subject.meshPapillomavirus E7 Proteinsen_HK
dc.subject.meshRepetitive Sequences, Nucleic Acid - geneticsen_HK
dc.subject.meshRepressor Proteinsen_HK
dc.subject.meshTelomere - chemistry - geneticsen_HK
dc.titleAbsence or low number of telomere repeats at junctions of dicentric chromosomesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-2257&volume=24&spage=83&epage=86&date=1999&atitle=Absence+or+low+number+of+telomere+repeats+at+junctions+of+dicentric+chromosomesen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1098-2264(199901)24:1<83::AID-GCC12>3.0.CO;2-Cen_HK
dc.identifier.pmid9892113-
dc.identifier.scopuseid_2-s2.0-0032890295en_HK
dc.identifier.hkuros39152en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032890295&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue1en_HK
dc.identifier.spage83en_HK
dc.identifier.epage86en_HK
dc.identifier.isiWOS:000077218900012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridMartens, UM=7004449120en_HK
dc.identifier.scopusauthoridPoon, SSS=7102884266en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridLansdorp, PM=7101658202en_HK

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