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Article: Loss of heterozygosity on chromosome 14 in primary nasopharyngeal carcinoma

TitleLoss of heterozygosity on chromosome 14 in primary nasopharyngeal carcinoma
Authors
Keywordschromosome 14q
loss of heterozygosity
nasopharyngeal carcinoma
tumor suppressor gene
Issue Date1997
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 1997, v. 10 n. 5, p. 1047-1050 How to Cite?
AbstractMultiple genetic alterations are believed to be involved in the pathogenesis of nasopharyngeal carcinomas (NPC). Loss of heterozygosity (LOH) of chromosomes 3p, 9p and 11q were previously reported in NPC. In order to further define the genetic alterations in NPC, 42 pairs of normal and tumor DNA of NPC were examined for LOH on chromosomes 5p, 5q, 6q, 14q, 15q, 16p, 16q, 17q using 16 polymorphic microsatellite markers. Frequent LOH (33%; 7 out of 21 cases) was observed in chromosome 14q at locus D14s81 (14q31). In order to define the common region of deletion, nine polymorphic microsatellite markers on 14q were examined for LOH in NPC. A common region of deletion was defined in NPC at chromosome 14q24.3-q32.1 flanked by two microsatellite markers D14s76 and D14s45. The common region of deletion (14q24.3-32.1) identified in NPC overlapped with the deleted regions of 14q reported in several human cancers. In 2 cases of NPC, the pattern of LOH revealed the presence of another commonly deleted region defined by loci D14s63 and D14s69 (mapped to 14q11.1-24.1) and located proximal to locus D14s76 (14q24.3). This study suggests that multiple tumor suppressor genes present on chromosome 14q are involved in the pathogenesis of NPC.
Persistent Identifierhttp://hdl.handle.net/10722/67404
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, RYSen_HK
dc.contributor.authorLo, KWen_HK
dc.contributor.authorHuang, DPen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2010-09-06T05:54:51Z-
dc.date.available2010-09-06T05:54:51Z-
dc.date.issued1997en_HK
dc.identifier.citationInternational Journal Of Oncology, 1997, v. 10 n. 5, p. 1047-1050en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67404-
dc.description.abstractMultiple genetic alterations are believed to be involved in the pathogenesis of nasopharyngeal carcinomas (NPC). Loss of heterozygosity (LOH) of chromosomes 3p, 9p and 11q were previously reported in NPC. In order to further define the genetic alterations in NPC, 42 pairs of normal and tumor DNA of NPC were examined for LOH on chromosomes 5p, 5q, 6q, 14q, 15q, 16p, 16q, 17q using 16 polymorphic microsatellite markers. Frequent LOH (33%; 7 out of 21 cases) was observed in chromosome 14q at locus D14s81 (14q31). In order to define the common region of deletion, nine polymorphic microsatellite markers on 14q were examined for LOH in NPC. A common region of deletion was defined in NPC at chromosome 14q24.3-q32.1 flanked by two microsatellite markers D14s76 and D14s45. The common region of deletion (14q24.3-32.1) identified in NPC overlapped with the deleted regions of 14q reported in several human cancers. In 2 cases of NPC, the pattern of LOH revealed the presence of another commonly deleted region defined by loci D14s63 and D14s69 (mapped to 14q11.1-24.1) and located proximal to locus D14s76 (14q24.3). This study suggests that multiple tumor suppressor genes present on chromosome 14q are involved in the pathogenesis of NPC.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Oncologyen_HK
dc.subjectchromosome 14qen_HK
dc.subjectloss of heterozygosityen_HK
dc.subjectnasopharyngeal carcinomaen_HK
dc.subjecttumor suppressor geneen_HK
dc.titleLoss of heterozygosity on chromosome 14 in primary nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=10&issue=5&spage=1047&epage=1050&date=1997&atitle=Loss+of+heterozygosity+on+chromosome+14+in+primary+nasopharyngeal+carcinomaen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid21533483-
dc.identifier.scopuseid_2-s2.0-0030967564en_HK
dc.identifier.hkuros23522en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030967564&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1047en_HK
dc.identifier.epage1050en_HK
dc.identifier.isiWOS:A1997WW11900027-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridCheng, RYS=7201955319en_HK
dc.identifier.scopusauthoridLo, KW=17344013500en_HK
dc.identifier.scopusauthoridHuang, DP=7403891486en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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