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Article: Expression of p75 neurotrophin receptor in the injured and regenerating rat retina

TitleExpression of p75 neurotrophin receptor in the injured and regenerating rat retina
Authors
Hu, BYip, HKSo, KF
KeywordsAxotomy
Muller cell
P75 neurotrophin receptor
Regeneration
RGC
Issue Date1999
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 1999, v. 10 n. 6, p. 1293-1297 How to Cite?
DOI: http://dx.doi.org/10.1097/00001756-199904260-00026
AbstractTHE low affinity neurotrophin receptor (p75) has been suggested to be involved in apoptosis after neuronal injury. The tempo-spatial expression of p75 in the axotomized and regenerating retinas has not yet been determined. We examined the expression of p75 in the RGCs of these retinas using 192-IgG immunohistochemistry. The failure to detect p75 immunoreactivity on retrogradely fluorogold (FG)-labeled retinal ganglion cells (RGCs) in axotomized and regenerating adult retinas indicated that p75 was not expressed on RGCs. The low affinity p75 receptor was mainly localized on the Muller cell processes identified with vimentin antibody. Since p75 is not present in RGCs, the proposed pro-apoptotic role of p75 involved in the RGC death after optic nerve injury is unlikely to occur in rats.
Persistent Identifierhttp://hdl.handle.net/10722/67403
ISSN
0959-4965
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.459
ISI Accession Number ID
WOS:000080488200027
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHu, Ben_HK
dc.contributor.authorYip, HKen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:54:50Z-
dc.date.available2010-09-06T05:54:50Z-
dc.date.issued1999en_HK
dc.identifier.citationNeuroreport, 1999, v. 10 n. 6, p. 1293-1297en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67403-
dc.description.abstractTHE low affinity neurotrophin receptor (p75) has been suggested to be involved in apoptosis after neuronal injury. The tempo-spatial expression of p75 in the axotomized and regenerating retinas has not yet been determined. We examined the expression of p75 in the RGCs of these retinas using 192-IgG immunohistochemistry. The failure to detect p75 immunoreactivity on retrogradely fluorogold (FG)-labeled retinal ganglion cells (RGCs) in axotomized and regenerating adult retinas indicated that p75 was not expressed on RGCs. The low affinity p75 receptor was mainly localized on the Muller cell processes identified with vimentin antibody. Since p75 is not present in RGCs, the proposed pro-apoptotic role of p75 involved in the RGC death after optic nerve injury is unlikely to occur in rats.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroReport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectAxotomy-
dc.subjectMuller cell-
dc.subjectP75 neurotrophin receptor-
dc.subjectRegeneration-
dc.subjectRGC-
dc.subject.meshAnimalsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor, Nerve Growth Factoren_HK
dc.subject.meshReceptors, Nerve Growth Factor - analysis - biosynthesisen_HK
dc.subject.meshRetina - injuries - physiologyen_HK
dc.subject.meshRetinal Ganglion Cells - cytology - physiologyen_HK
dc.subject.meshTime Factorsen_HK
dc.titleExpression of p75 neurotrophin receptor in the injured and regenerating rat retinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=10&spage=1293&epage=1297&date=1999&atitle=Expression+of+p75+neurotrophin+receptor+in+the+injured+and+regenerating+rat+retinaen_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-199904260-00026-
dc.identifier.pmid10363942-
dc.identifier.scopuseid_2-s2.0-0033606054en_HK
dc.identifier.hkuros46130en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033606054&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1293en_HK
dc.identifier.epage1297en_HK
dc.identifier.isiWOS:000080488200027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHu, B=35733928400en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.issnl0959-4965-

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