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Article: Significance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cells

TitleSignificance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cells
Authors
KeywordsCisplatin
Nasopharyngeal carcinoma
Radiation
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anti-cancerdrugs.com
Citation
Anti-Cancer Drugs, 2002, v. 13 n. 9, p. 957-964 How to Cite?
AbstractThe use of cisplatin as a potential radiosensitizer in nasopharyngeal carcinoma (NPC) has produced encouraging results in clinical trials. In order to provide information on improving the design of clinical treatments, we investigated the effect of cisplatin dose, and the time interval and sequence between administration of cisplatin and radiation on cell survival of two NPC cell lines, CNE1 and SUNE1. When cisplatin was applied first, an exposure time of 24 h resulted in up to 2.6-fold increase in cell death and 7-fold increase in radiation effect (cell survival after cisplatin/cell survival after cisplatin plus radiation) in the cisplatin-radiation combination treatment compared to the cells treated with cisplatin for 4 h. When radiation was applied first, a shorter interval time of 4 h followed by cisplatin treatment resulted in up to 3-fold increase in cell death and a 3-fold enhanced radiation effect over longer time intervals of 24 h. By changing the order of radiation and cisplatin treatment alone, a 2-fold difference in radiation effect was observed. The differential cytotoxicity was partially explained by the alterations in cell cycle distribution. Our results indicate the importance of scheduling the radiation and cisplatin combination regimens on the survival of NPC cells. © 2002 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/67395
ISSN
2015 Impact Factor: 2.268
2015 SCImago Journal Rankings: 0.795
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Xen_HK
dc.contributor.authorChow, LSNen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2010-09-06T05:54:46Z-
dc.date.available2010-09-06T05:54:46Z-
dc.date.issued2002en_HK
dc.identifier.citationAnti-Cancer Drugs, 2002, v. 13 n. 9, p. 957-964en_HK
dc.identifier.issn0959-4973en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67395-
dc.description.abstractThe use of cisplatin as a potential radiosensitizer in nasopharyngeal carcinoma (NPC) has produced encouraging results in clinical trials. In order to provide information on improving the design of clinical treatments, we investigated the effect of cisplatin dose, and the time interval and sequence between administration of cisplatin and radiation on cell survival of two NPC cell lines, CNE1 and SUNE1. When cisplatin was applied first, an exposure time of 24 h resulted in up to 2.6-fold increase in cell death and 7-fold increase in radiation effect (cell survival after cisplatin/cell survival after cisplatin plus radiation) in the cisplatin-radiation combination treatment compared to the cells treated with cisplatin for 4 h. When radiation was applied first, a shorter interval time of 4 h followed by cisplatin treatment resulted in up to 3-fold increase in cell death and a 3-fold enhanced radiation effect over longer time intervals of 24 h. By changing the order of radiation and cisplatin treatment alone, a 2-fold difference in radiation effect was observed. The differential cytotoxicity was partially explained by the alterations in cell cycle distribution. Our results indicate the importance of scheduling the radiation and cisplatin combination regimens on the survival of NPC cells. © 2002 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anti-cancerdrugs.comen_HK
dc.relation.ispartofAnti-Cancer Drugsen_HK
dc.rightsAnti-Cancer Drugs. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectCisplatinen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectRadiationen_HK
dc.titleSignificance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4973&volume=13&spage=957&epage=964&date=2002&atitle=Significance+of+scheduling+on+the+cytotoxicity+of+radiation+and+cisplatin+combination+treatment+in+nasopharyngeal+carcinoma+cellsen_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001813-200210000-00008en_HK
dc.identifier.pmid12394259-
dc.identifier.scopuseid_2-s2.0-1842855111en_HK
dc.identifier.hkuros76728en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842855111&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue9en_HK
dc.identifier.spage957en_HK
dc.identifier.epage964en_HK
dc.identifier.isiWOS:000179405700008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridChow, LSN=7202533094en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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