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Article: Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation

TitleDifferential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation
Authors
KeywordsActivity modifying proteins
Plasma
Receptor
Issue Date2007
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npep
Citation
Neuropeptides, 2007, v. 41 n. 3, p. 177-187 How to Cite?
AbstractAdrenomedullin (AM) has been shown to be present in the stomach but the role of gastric AM is obscure. To investigate the effects of starvation on AM in the stomach, we studied the changes in gene expression of preproadrenomedullin (preproAM) and AM receptors by reverse transcription-polymerase chain reaction (RT-PCR), and tissue AM concentrations by radioimmunoassay (RIA) in the fundus and pylorus of the stomach of rats subjected to either acute (1-day) or chronic (4-day) starvation. An up-regulation of preproAM gene expression was observed in the fundus after acute starvation, and in the pylorus after chronic starvation. Immunoreactive AM (ir-AM) levels were increased in both fundus and pylorus after chronic starvation. In addition, marked reductions in the gene expression of fundic calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 3 as well as the pyloric CRLR and RAMP2 were observed in the chronically starved rats. The present study suggests that the gene expression of preproadrenomedullin mRNA is differentially regulated by starvation in the different parts of the stomach. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67385
ISSN
2015 Impact Factor: 2.726
2015 SCImago Journal Rankings: 1.165
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMan, SYen_HK
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorLi, YYen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorSheng, HPen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T05:54:40Z-
dc.date.available2010-09-06T05:54:40Z-
dc.date.issued2007en_HK
dc.identifier.citationNeuropeptides, 2007, v. 41 n. 3, p. 177-187en_HK
dc.identifier.issn0143-4179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67385-
dc.description.abstractAdrenomedullin (AM) has been shown to be present in the stomach but the role of gastric AM is obscure. To investigate the effects of starvation on AM in the stomach, we studied the changes in gene expression of preproadrenomedullin (preproAM) and AM receptors by reverse transcription-polymerase chain reaction (RT-PCR), and tissue AM concentrations by radioimmunoassay (RIA) in the fundus and pylorus of the stomach of rats subjected to either acute (1-day) or chronic (4-day) starvation. An up-regulation of preproAM gene expression was observed in the fundus after acute starvation, and in the pylorus after chronic starvation. Immunoreactive AM (ir-AM) levels were increased in both fundus and pylorus after chronic starvation. In addition, marked reductions in the gene expression of fundic calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 3 as well as the pyloric CRLR and RAMP2 were observed in the chronically starved rats. The present study suggests that the gene expression of preproadrenomedullin mRNA is differentially regulated by starvation in the different parts of the stomach. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npepen_HK
dc.relation.ispartofNeuropeptidesen_HK
dc.subjectActivity modifying proteinsen_HK
dc.subjectPlasmaen_HK
dc.subjectReceptoren_HK
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshAdrenomedullin - biosynthesis - genetics - physiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBody Weight - physiologyen_HK
dc.subject.meshChromatography, Gelen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshGastric Fundus - metabolism - physiologyen_HK
dc.subject.meshGene Expression Regulation - physiologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshOrgan Size - physiologyen_HK
dc.subject.meshPylorus - metabolism - physiologyen_HK
dc.subject.meshRNA, Messenger - biosynthesisen_HK
dc.subject.meshRadioimmunoassayen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshStarvation - genetics - physiopathologyen_HK
dc.subject.meshStomach - metabolism - physiopathologyen_HK
dc.titleDifferential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-4179&volume=41&spage=177&epage=187&date=2007&atitle=Differential+regulation+of+adrenomedullin+gene+expression+in+the+fundic+and+pyloric+regions+of+the+rat+stomach+during+acute+and+chronic+starvationen_HK
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.npep.2006.12.006en_HK
dc.identifier.pmid17335899-
dc.identifier.scopuseid_2-s2.0-34247603539en_HK
dc.identifier.hkuros127837en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247603539&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue3en_HK
dc.identifier.spage177en_HK
dc.identifier.epage187en_HK
dc.identifier.isiWOS:000247040700005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMan, SY=55182323500en_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridLi, YY=8293496300en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridSheng, HP=7201933542en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

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