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Article: Ablation of paternal accessory sex glands imparts physical and behavioural abnormalities to the progeny: An in vivo study in the golden hamster

TitleAblation of paternal accessory sex glands imparts physical and behavioural abnormalities to the progeny: An in vivo study in the golden hamster
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/theriogenology
Citation
Theriogenology, 2007, v. 68 n. 4, p. 654-662 How to Cite?
AbstractThe functional significance of male accessory sex glands (ASG) remains unclear. This study explored their importance in reproduction. In previous investigations, embryos sired by males with ASG either totally or partially removed had a shift in the cell cycle and delayed cleavage during preimplantation development, higher incidence of apoptosis, early oviductal-uterine transit, higher proportion of embryo degeneration, lower implantation rate, and ultimately reduced fertility and fecundity. Some pups were born alive; but would they be normal? We hypothesized that the first generation offspring (F1) could also bear undesirable traits. To test our hypothesis, we raised and studied these F1 pups from birth to 8 weeks. We monitored physical growth and assessed behaviour such as nest patch odor preference, acoustic startle response (ASR) and exploratory activity. We detected deviations from the norm in physical growth, a premature cessation of nest patch odor preferences, accelerated acoustic startle habituation and more frequent rearing when exposed to a novel environment. In terms of structure, we found one incidence of diphallus with duplicated urethra. We concluded that sperm lacking contact with ASG secretions gave rise to progeny with abnormal traits. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67377
ISSN
2015 Impact Factor: 1.838
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CLen_HK
dc.contributor.authorLee, KHen_HK
dc.contributor.authorLo, KMen_HK
dc.contributor.authorChan, OCen_HK
dc.contributor.authorGoggins, Wen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorChow, PHen_HK
dc.date.accessioned2010-09-06T05:54:35Z-
dc.date.available2010-09-06T05:54:35Z-
dc.date.issued2007en_HK
dc.identifier.citationTheriogenology, 2007, v. 68 n. 4, p. 654-662en_HK
dc.identifier.issn0093-691Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67377-
dc.description.abstractThe functional significance of male accessory sex glands (ASG) remains unclear. This study explored their importance in reproduction. In previous investigations, embryos sired by males with ASG either totally or partially removed had a shift in the cell cycle and delayed cleavage during preimplantation development, higher incidence of apoptosis, early oviductal-uterine transit, higher proportion of embryo degeneration, lower implantation rate, and ultimately reduced fertility and fecundity. Some pups were born alive; but would they be normal? We hypothesized that the first generation offspring (F1) could also bear undesirable traits. To test our hypothesis, we raised and studied these F1 pups from birth to 8 weeks. We monitored physical growth and assessed behaviour such as nest patch odor preference, acoustic startle response (ASR) and exploratory activity. We detected deviations from the norm in physical growth, a premature cessation of nest patch odor preferences, accelerated acoustic startle habituation and more frequent rearing when exposed to a novel environment. In terms of structure, we found one incidence of diphallus with duplicated urethra. We concluded that sperm lacking contact with ASG secretions gave rise to progeny with abnormal traits. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/theriogenologyen_HK
dc.relation.ispartofTheriogenologyen_HK
dc.rightsTheriogenology. Copyright © Elsevier Inc.en_HK
dc.subject.meshAbnormalities, Multiple - etiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshBehavior, Animal - physiologyen_HK
dc.subject.meshBirth Weight - physiologyen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshEmbryonic Development - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenitalia, Male - physiology - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNesting Behavior - physiologyen_HK
dc.subject.meshOdorsen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshStartle Reactionen_HK
dc.titleAblation of paternal accessory sex glands imparts physical and behavioural abnormalities to the progeny: An in vivo study in the golden hamsteren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0093-691X&volume=68&spage=654&epage=662&date=2007&atitle=Ablation+of+paternal+accessory+sex+glands+imparts+physical+and+behavioural+abnormalities+to+the+progeny:+An+in+vivo+study+in+the+golden+hamsteren_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.theriogenology.2007.04.062en_HK
dc.identifier.pmid17597198-
dc.identifier.scopuseid_2-s2.0-34547124327en_HK
dc.identifier.hkuros136096en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547124327&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue4en_HK
dc.identifier.spage654en_HK
dc.identifier.epage662en_HK
dc.identifier.isiWOS:000248662300015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, CL=26535204400en_HK
dc.identifier.scopusauthoridLee, KH=7501505976en_HK
dc.identifier.scopusauthoridLo, KM=34968401500en_HK
dc.identifier.scopusauthoridChan, OC=23049435400en_HK
dc.identifier.scopusauthoridGoggins, W=6701315434en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridChow, PH=7202656919en_HK

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