File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0006-8993(92)91471-P
- Scopus: eid_2-s2.0-0026437555
- PMID: 1361411
- WOS: WOS:A1992JY25900027
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: APV prevents the elimination of transient dendritic spines on a population of retinal ganglion cells
Title | APV prevents the elimination of transient dendritic spines on a population of retinal ganglion cells |
---|---|
Authors | |
Keywords | Development dl-2-amino-5-phosphonovaleric acid NMDA receptor Retinal ganglion cell Transient dendritic spine |
Issue Date | 1992 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres |
Citation | Brain Research, 1992, v. 595 n. 1, p. 171-174 How to Cite? |
Abstract | Blockade of the N-methyl-D-aspartate (NMDA) receptors on retinal ganglion cells (RGCs) during development prevents the elimination of the exuberant spine-like processes in a population of Type I RGCs in hamsters. During the development of RGCs, exuberant dendritic spines have been observed which disappear during maturation. Blocking the NMDA receptors on developing RGCs with the antagonist, DL-2-amino-5-phosphonovaleric acid (APV) and the subsequent retention of some of the normally transient dendritic spines suggest that the morphological development of post-synaptic neurons may be affected by this treatment. Our result further suggests that the elimination of exuberant spines during normal development requires interactions between receptors on the spines and neurotransmitters released by the pre-synaptic inputs. |
Persistent Identifier | http://hdl.handle.net/10722/67373 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, KC | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.contributor.author | Tay, D | en_HK |
dc.date.accessioned | 2010-09-06T05:54:33Z | - |
dc.date.available | 2010-09-06T05:54:33Z | - |
dc.date.issued | 1992 | en_HK |
dc.identifier.citation | Brain Research, 1992, v. 595 n. 1, p. 171-174 | en_HK |
dc.identifier.issn | 0006-8993 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67373 | - |
dc.description.abstract | Blockade of the N-methyl-D-aspartate (NMDA) receptors on retinal ganglion cells (RGCs) during development prevents the elimination of the exuberant spine-like processes in a population of Type I RGCs in hamsters. During the development of RGCs, exuberant dendritic spines have been observed which disappear during maturation. Blocking the NMDA receptors on developing RGCs with the antagonist, DL-2-amino-5-phosphonovaleric acid (APV) and the subsequent retention of some of the normally transient dendritic spines suggest that the morphological development of post-synaptic neurons may be affected by this treatment. Our result further suggests that the elimination of exuberant spines during normal development requires interactions between receptors on the spines and neurotransmitters released by the pre-synaptic inputs. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres | en_HK |
dc.relation.ispartof | Brain Research | en_HK |
dc.rights | Brain Research. Copyright © Elsevier BV. | en_HK |
dc.subject | Development | - |
dc.subject | dl-2-amino-5-phosphonovaleric acid | - |
dc.subject | NMDA receptor | - |
dc.subject | Retinal ganglion cell | - |
dc.subject | Transient dendritic spine | - |
dc.subject.mesh | 2-Amino-5-phosphonovalerate - pharmacology | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Cricetinae | en_HK |
dc.subject.mesh | Dendrites - drug effects | en_HK |
dc.subject.mesh | Isoquinolines | en_HK |
dc.subject.mesh | Receptors, N-Methyl-D-Aspartate - drug effects | en_HK |
dc.subject.mesh | Retinal Ganglion Cells - drug effects - ultrastructure | en_HK |
dc.subject.mesh | Superior Colliculi - cytology - drug effects | en_HK |
dc.subject.mesh | Tetrodotoxin - pharmacology | en_HK |
dc.title | APV prevents the elimination of transient dendritic spines on a population of retinal ganglion cells | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=595&spage=171&epage=174&date=1992&atitle=APV+prevents+the+elimination+of+transient+dendritic+spines+on+a+population+of+retinal+ganglion+cells | en_HK |
dc.identifier.email | So, KF:hrmaskf@hkucc.hku.hk | en_HK |
dc.identifier.email | Tay, D:dkctay@hkucc.hku.hk | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.identifier.authority | Tay, D=rp00336 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0006-8993(92)91471-P | en_HK |
dc.identifier.pmid | 1361411 | - |
dc.identifier.scopus | eid_2-s2.0-0026437555 | en_HK |
dc.identifier.hkuros | 97747 | en_HK |
dc.identifier.volume | 595 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 171 | en_HK |
dc.identifier.epage | 174 | en_HK |
dc.identifier.isi | WOS:A1992JY25900027 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Lau, KC=16407204200 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.scopusauthorid | Tay, D=7006796825 | en_HK |
dc.identifier.issnl | 0006-8993 | - |