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Article: APV prevents the elimination of transient dendritic spines on a population of retinal ganglion cells

TitleAPV prevents the elimination of transient dendritic spines on a population of retinal ganglion cells
Authors
Issue Date1992
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1992, v. 595 n. 1, p. 171-174 How to Cite?
AbstractBlockade of the N-methyl-D-aspartate (NMDA) receptors on retinal ganglion cells (RGCs) during development prevents the elimination of the exuberant spine-like processes in a population of Type I RGCs in hamsters. During the development of RGCs, exuberant dendritic spines have been observed which disappear during maturation. Blocking the NMDA receptors on developing RGCs with the antagonist, DL-2-amino-5-phosphonovaleric acid (APV) and the subsequent retention of some of the normally transient dendritic spines suggest that the morphological development of post-synaptic neurons may be affected by this treatment. Our result further suggests that the elimination of exuberant spines during normal development requires interactions between receptors on the spines and neurotransmitters released by the pre-synaptic inputs.
Persistent Identifierhttp://hdl.handle.net/10722/67373
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, KCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorTay, Den_HK
dc.date.accessioned2010-09-06T05:54:33Z-
dc.date.available2010-09-06T05:54:33Z-
dc.date.issued1992en_HK
dc.identifier.citationBrain Research, 1992, v. 595 n. 1, p. 171-174en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67373-
dc.description.abstractBlockade of the N-methyl-D-aspartate (NMDA) receptors on retinal ganglion cells (RGCs) during development prevents the elimination of the exuberant spine-like processes in a population of Type I RGCs in hamsters. During the development of RGCs, exuberant dendritic spines have been observed which disappear during maturation. Blocking the NMDA receptors on developing RGCs with the antagonist, DL-2-amino-5-phosphonovaleric acid (APV) and the subsequent retention of some of the normally transient dendritic spines suggest that the morphological development of post-synaptic neurons may be affected by this treatment. Our result further suggests that the elimination of exuberant spines during normal development requires interactions between receptors on the spines and neurotransmitters released by the pre-synaptic inputs.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subject.mesh2-Amino-5-phosphonovalerate - pharmacologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshDendrites - drug effectsen_HK
dc.subject.meshIsoquinolinesen_HK
dc.subject.meshReceptors, N-Methyl-D-Aspartate - drug effectsen_HK
dc.subject.meshRetinal Ganglion Cells - drug effects - ultrastructureen_HK
dc.subject.meshSuperior Colliculi - cytology - drug effectsen_HK
dc.subject.meshTetrodotoxin - pharmacologyen_HK
dc.titleAPV prevents the elimination of transient dendritic spines on a population of retinal ganglion cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=595&spage=171&epage=174&date=1992&atitle=APV+prevents+the+elimination+of+transient+dendritic+spines+on+a+population+of+retinal+ganglion+cellsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityTay, D=rp00336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0006-8993(92)91471-Pen_HK
dc.identifier.pmid1361411-
dc.identifier.scopuseid_2-s2.0-0026437555en_HK
dc.identifier.hkuros97747en_HK
dc.identifier.volume595en_HK
dc.identifier.issue1en_HK
dc.identifier.spage171en_HK
dc.identifier.epage174en_HK
dc.identifier.isiWOS:A1992JY25900027-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLau, KC=16407204200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridTay, D=7006796825en_HK

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